Academic Articles & Research Papers

Molecular characterization and prognostic modeling associated with M2-like tumor-associated macrophages in breast cancer: revealing the immunosuppressive role of DLG3

BackgroundM2-like tumor-associated macrophages (TAMs) promote an immunosuppressive microenvironment and contribute to tumor progression and metastasis. However, their molecular characterization and prognostic value have not been fully explo...

Binarized Neural Networks: Training Deep Neural Networks with Weights and Activations Constrained to +1 or -1

We introduce a method to train Binarized Neural Networks (BNNs) - neural networks with binary weights and activations at run-time. At training-time the binary weights and activations are used for computing the parameters gradients. During t...

A NEURAL NETWORK PRIMER

Neural networks are composed of basic units somewhat analogous to neurons. These units are linked to each other by connections whose strength is modifiable as a result of a learning process or algorithm. Each of these units integrates indep...

Multilayer perceptron and neural networks

Abstract:- The attempts for solving linear inseparable problems have led to different variations on the number of layers of neurons and activation functions used. The backpropagation algorithm is the most known and used supervised learning ...

Self-Normalizing Neural Networks

Deep Learning has revolutionized vision via convolutional neural networks (CNNs) and natural language processing via recurrent neural networks (RNNs). However, success stories of Deep Learning with standard feed-forward neural networks (FNN...

Quantized Neural Networks: Training Neural Networks with Low Precision Weights and Activations

We introduce a method to train Quantized Neural Networks (QNNs) --- neural networks with extremely low precision (e.g., 1-bit) weights and activations, at run-time. At train-time the quantized weights and activations are used for computing ...

Numerical computation of Brownian motion and thermophoresis effects on rotational micropolar nanomaterials with activation energy

The current article investigates the numerical study of the micropolar nanofluid flow through a 3D rotating surface. This communication may manipulate for the aim such as the delivery of the drug, cooling of electronic chips, nanoscience an...

Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: a Prospective Pilot Study

Introduction: Coagulation and fibrinolysis remain sparsely addressed with regards to acute respiratory distress syndrome (ARDS). We hypothesized that ARDS development might be associated with changes in plasma coagulation and fibrinolysis. ...

Cyclic order superpositions enable quantum information transmission through completely depolarizing channels

Abstract Noise fundamentally limits quantum communication capacity, completely preventing information transmission in fully depolarizing environments. While indefinite causal order theoretically circumvents this limitation, experimentally r...

CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling

Abstract Background Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (H...

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

Alterations in the composition of the intestinal microbiota have been correlated with aging and measures of frailty in the elderly. However, the relationships between microbial dynamics, age-related changes in intestinal physiology, and org...

Molecular Biology of Neuroblastoma

UNLABELLED: PURPOSE AND RESULTS: Neuroblastoma, the most common solid extracranial neoplasm in children, is remarkable for its clinical heterogeneity. Complex patterns of genetic abnormalities interact to determine the clinical phenotype. T...

Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity

Air pollution as one of the ravages of our modern societies is primarily linked to urban centers, industrial activities, or road traffic. These atmospheric pollutants have been incriminated in deleterious health effects by numerous epidemio...

The Role of Mast Cells and Their Potential as a Therapeutic Target For Neuroinflammation

Sarah Adriana Scuderi,1 Rossella Basilotta,2 Laura Cucinotta,2 Alessio Ardizzone,3 Emanuela Esposito21Genetics and Pharmacogenetics Unit, ‘Gaetano Martino’ University Hospital, Messina, Italy; 2Department of Chemical, Biological, Pharmaceut...

Toll-like receptor 2 coordinates induction of IL-22 in lung macrophages following organic dust-induced inflammation

IntroductionOrganic dust exposures, particularly in occupational settings, induce airway inflammation and contribute to the development and progression of chronic lung disease and impaired tissue regeneration. Interleukin-22 (IL-22) is a pl...

Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth

Tazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential as a promising therapeutic agent for treating melanoma in situ. Its primary mechanism o...

Incarcerated youth with history of childhood trauma are characterized by altered neural activation during a Go/NoGo fMRI task.

S100A9 Mediates Neuroblastoma-Associated Skeletal Muscle Atrophy via O-GlcNAcylation Repression and Activate Mitophagy Activation.

Catalytic effect comparison of TiO2 and La2O3 on hydrogen storage thermodynamics and kinetics of the as-milled La-Sm-Mg-Ni-based alloy

In this investigation, mechanical grinding was applied to fabricating the Mg-based alloys La7Sm3Mg80Ni10 + 5 wt.% M (M = None, TiO2, La2O3) (named La7Sm3Mg80Ni10–5 M (M = None, TiO2, La2O3)). The result reveals that the structures of as-mil...

Epigenetic Activation of ANGPTL4 Drives EBV-Negative Gastric Cancer via Neutrophil Recruitment and NET Release via Stabilizing ANXA5.