Academic Articles & Research Papers

Depressive phenotype shapes behavioral, neuroendocrine and molecular responses to repetitive transcranial magnetic stimulation in preclinical models of depression

IntroductionRepetitive transcranial magnetic stimulation (rTMS) is an established non-invasive treatment for treatment-resistant depression (TRD), yet its neurobiological mechanisms remain only partially understood. We investigated whether ...

Combination of Antimicrobial Starters for Feed Fermentation: Influence on Piglet Feces Microbiota and Health and Growth Performance, Including Mycotoxin Biotransformation in vivo

The aim of this study was to apply a combination of the microbial starters Lactobacillus uvarum LUHS245, Lactobacillus casei LUHS210, Pediococcus acidilactici LUHS29, and Pediococcus pentosaceus LUHS183 for feed fermentation and to evaluate...

Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau

Mild cognitive impairment (MCI) can be an early manifestation of Alzheimer’s disease (AD) pathology, other pathologic entities [e.g., cerebrovascular disease, Lewy body disease, LATE (limbic-predominant age-related TDP-43 encephalopathy)], ...

Behavioral dataset for Long-Evans and its schizophrenia-like substrain through several generations

Abstract We present a high-throughput behavioral dataset acquired with Ambitus, an automated reward-based corridor system that records locomotor and exploratory activities and cognitive functions after minimal handling. The collection conta...

Dopamine transporter binding in symptomatic controls and healthy volunteers: Considerations for neuroimaging trials

Objective: To evaluate possible differences between brain dopamine transporter (DAT) binding in a group of symptomatic parkinsonism patients without dopaminergic degeneration and healthy individuals. Background: Dopaminergic neuroimaging st...

Early Retinal Microvascular Alterations in Young Type 1 Diabetic Patients without Clinical Retinopathy

The purpose of this study is to identify and quantify preclinical changes with the help of optical coherence tomography angiography (OCTA) within the retinal microcirculation of young type 1 diabetes (T1D) patients without clinical signs of...

Correction: Five-year dementia prediction and decision support system based on real-world data

Medical Informatics

Description Logics and related formalisms are being applied in at least five applications in medical informatics – terminology, intelligent user interfaces, decision support and semantic indexing, language technology, and systems integratio...

Medical informatics

Description Logics and related formalisms are being applied in at least five applications in medical informatics - terminology, intelligent user interfaces, decision support and indexing, technology, and systems integration. Important issue...

A Review of Age-related Macular Degeneration and Current Concepts in Management

Age-related macular degeneration (AMD) is a prevalent and progressive retinal disease that affects a substantial number of elderly individuals worldwide. This manuscript provides a comprehensive overview of the current concepts in the manag...

Mortality trends among hospitalised COVID-19 patients in Sweden: A nationwide observational cohort study

Background: It is important to know if mortality among hospitalised COVID-19 patients has changed as the pandemic has progressed. The aim of this study was to describe the dynamics over time of mortality among patients hospitalised for COVI...

Neuroscience and education

Neuroscience is a relatively new discipline encompassing neurology, psychology and biology. It has made great strides in the last 100 years, during which many aspects of the physiology, biochemistry, pharmacology and structure of the verteb...

Dynamical Systems in Neuroscience

Explains the relationship of electrophysiology, nonlinear dynamics, and the computational properties of neurons, with each concept presented in terms of both neuroscience and mathematics and illustrated using geometrical intuition. In order...

Prefrontal cortical deficits are a putative susceptibility factor for PTSD

IntroductionOnly a subset of people who experience a traumatic event develop Post-Traumatic Stress Disorder (PTSD) suggesting that there are susceptibility factors influencing PTSD pathophysiology. While post trauma sequelae factors are ext...

Encyclopedia of Neuroscience

Notice the subject of this book: not "neurosciences" but "neuroscience." During the past 20 years, rapidly accelerating advances in neurochemistry, neurophysiology, neurobiology, neuropharmacology, neuroanatomy, etc, have brought about an e...

Storage Properties of Double-Layer Films Enriched with <i>Phytolacca americana</i> L. Extract as Active Packaging for African Catfish, with a New Approach to Antioxidant Film Assay and Additional Analysis of <i>P. americana</i> Extract Toxicity on Human Cell Lines

Novel double-layer films based on furcellaran (FUR) and gelatin (GEL) with the addition of Phytolacca americana L. (PA) extract were used as active packaging for African catfish fillets. Films with PA extract have been shown to minimize the...

Antibacterial and antioxidant effects of Punicalagin extracts from Punica granatum peels

The growing recognition of the health-promoting potential of compounds derived from natural sources, particularly those exhibiting antimicrobial and antioxidant activities, has resulted in a surge of research publications dedicated to explo...

Mitophagy: An Emergence of New Player in Alzheimer’s Disease

Mitochondria provide neurons not only energy as ATP to keep them growing, proliferating and developing, but they also control apoptosis. Due to their high bioenergetic demand, neurons which are highly specific terminally differentiated cell...

Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases

The Mitochondria is a critical sub-cellular organelle that plays an integral part in a normal cellular process. Besides ATP production, the mitochondria participate in various key cellular processes such as cell signaling, epigenetic regula...

Evidence for the Effectiveness of Remdesivir (GS-5734), a Nucleoside-Analog Antiviral Drug in the Inhibition of IK(M) or IK(DR) and in the Stimulation of IMEP

Remdesivir (RDV, GS-5734), a broad-spectrum antiviral drug in the class of nucleotide analogs, has been particularly tailored for treatment of coronavirus infections. However, to which extent RDV is able to modify various types of membrane ...