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Showing 20 of 416 academic articles

Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat

Daniel M. Stout, Alexander J. Shackman, Walker S. Pedersen, Tara A. Miskovich et al. • Scientific Reports (2017)

Abstract Dispositional anxiety is a trait-like phenotype that confers increased risk for a range of debilitating neuropsychiatric disorders. Like many patients with anxiety disorders, individuals with elevated levels of dispositional anxiet...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-017-08443-7

Contrast Sensitivity Is Associated With Chorioretinal Thickness and Vascular Density of Eyes in Simple Early-Stage High Myopia

Xinting Liu, Yanli Wang, Xiaoxiao Ying, Fen Zhang et al. • Frontiers in Medicine (2022)

ObjectiveTo evaluate the contrast sensitivity function (CSF), chorioretinal thickness and vascular density as well as their relationships in subjects with simple early-stage high myopia.MethodsEighty-one young subjects were enrolled in this...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2022.847817

Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways

Elliya Park, Lily Yi Li, Chunsheng He, Azhar Z. Abbasi et al. • Advanced Science (2023)

Abstract Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new strategy, using multitargeted bi...

DOAJ Open Access (DOAJ) DOI: 10.1002/advs.202207238

Functional MRI of Handwriting Tasks: A Study of Healthy Young Adults Interacting with a Novel Touch-Sensitive Tablet

Mahta Karimpoor, Nathan W. Churchill, Fred Tam, Corinne E. Fischer et al. • Frontiers in Human Neuroscience (2018)

Handwriting is a complex human activity that engages a blend of cognitive and visual motor skills. Current understanding of the neural correlates of handwriting has largely come from lesion studies of patients with impaired handwriting. Tas...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnhum.2018.00030

Graphene Oxide and Reduced Derivatives, as Powder or Film Scaffolds, Differentially Promote Dopaminergic Neuron Differentiation and Survival

Noela Rodriguez-Losada, Noela Rodriguez-Losada, Rune Wendelbob, M. Carmen Ocaña et al. • Frontiers in Neuroscience (2020)

Emerging scaffold structures made of carbon nanomaterials, such as graphene oxide (GO) have shown efficient bioconjugation with common biomolecules. Previous studies described that GO promotes the differentiation of neural stem cells and ma...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2020.570409

Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts

Camila Fabiani, Camila Fabiani, Silvia S. Antollini, Silvia S. Antollini • Frontiers in Cellular Neuroscience (2019)

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with satu...

DOAJ Open Access (DOAJ) DOI: 10.3389/fncel.2019.00309

Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability

Yuxiong Lu, Junichi Maruyama, Keiko Kuwata, Hiroyuki Fukuda et al. • Biochemistry and Biophysics Reports (2018)

Doublecortin-like kinase 1 (DCLK1) is a serine/threonine-kinase with two doublecortin (DCX) domains. DCLK1 is associated with microtubules via DCX domains and regulates microtubule polymerization. DCLK1 is known to be expressed in cancer st...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.bbrep.2018.10.014

Total mercury exposure in early pregnancy has no adverse association with scholastic ability of the offspring particularly if the mother eats fish

Joseph Hibbeln, Steven Gregory, Yasmin Iles-Caven, Caroline M. Taylor et al. • Environment International (2018)

There is a public perception that relatively low doses of mercury found in seafood are harmful to the fetal brain but little consistent evidence to support this. In earlier publications we have shown no adverse associations between maternal...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.envint.2018.03.024

Cranial ultrasonographic findings in newborns exposed to SARS-CoV-2: a single-centre cross-sectional analysis

Bruna Scalia, Marco Andrea Nicola Saporito, Laura Mauceri, Alessandro Valerio Saporito et al. • Italian Journal of Pediatrics (2024)

Abstract Background SARS-CoV-2’s potential consequences on the developing brain are still unknown. The aim of this study was to describe cranial ultrasonographic (cUS) findings in a population of newborns exposed to SARS-CoV-2 born at San M...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13052-024-01826-3

Cerebrospinal fluid-stem cell interactions may pave the path for cell-based therapy in neurological diseases

Chao Ren, Peiyuan Yin, Neng Ren, Zhe Wang et al. • Stem Cell Research & Therapy (2018)

Abstract Recent studies have suggested that the regulation of endogenous neural stem cells (NSCs) or transplanting of exogenous nerve cells are the newest and most promising methods for the treatment of dementia and other neurological disea...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13287-018-0807-3

The Biomechanical Characteristics of Swallowing in Tracheostomized Patients with Aspiration following Acquired Brain Injury: A Cross-Sectional Study

Xiao-Xiao Han, Jia Qiao, Zhan-Ao Meng, Dong-Mei Pan et al. • Brain Sciences (2023)

Objectives: Investigate the biomechanical characteristics in tracheostomized patients with aspiration following acquired brain injury (ABI) and further explore the relationship between the biomechanical characteristics and aspiration. Metho...

DOAJ Open Access (DOAJ) DOI: 10.3390/brainsci13010091

Impact of early vs. late tracheostomy on clinical outcomes in mechanically ventilated patients with intracerebral hemorrhage extending into the ventricles: a retrospective cohort study based on quantitative assessment of parenchymal and intraventricular hematoma volumes

Minghui Lu, Jiajun Wei, Qiang Cai • Frontiers in Neurology (2026)

BackgroundThe optimal timing for tracheostomy in patients with intracerebral hemorrhage extending into the ventricles who require mechanical ventilation remains controversial, and there is a paucity of evidence to guide clinical practice. T...

DOAJ Open Access (DOAJ) DOI: 10.3389/fneur.2026.1724717

Does Practice Make Perfect? The Effects of an Eight-Week Manualized Deliberate Practice Course With Peer Feedback on Patient-Rated Working Alliance in Adults: A Pilot Randomized Controlled Trial

Håkan Lagerberg, James F. Boswell, Michael J. Constantino, Gerhard Andersson et al. • Clinical Psychology in Europe (2024)

[Background] Deliberate Practice (DP), which underscores the importance of expert mentorship, personalized learning objectives, feedback, and repetition, has been suggested as a method to enhance the effectiveness of therapists. [Method] Th...

DOAJ Open Access (DOAJ) DOI: 10.32872/cpe.12353

Effect of Overexpression of the Brain-Specific Na+/Ca2+ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells

Yuki Ota, Takuya Kawanai, Ryo Watanabe, Akira Nishimura et al. • Journal of Pharmacological Sciences (2013)

Abstract.: Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicit...

DOAJ Open Access (DOAJ) DOI: 10.1254/jphs.13012SC

Non-invasive large-scale imaging of concurrent neuronal, astrocytic, and hemodynamic activity with hybrid multiplexed fluorescence and magnetic resonance imaging (HyFMRI)

Zhenyue Chen, Yi Chen, Irmak Gezginer, Qingxiang Ding et al. • Light: Science & Applications (2025)

Abstract A critical gap currently exists in systematic understanding and experimental validation of the role of astrocytes in neurovascular coupling and their functional links with other brain cells. Despite a broad selection of functional ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41377-025-02003-9

Estimation of Time-Varying Coherence and Its Application in Understanding Brain Functional Connectivity

Cheng Liu, William Gaetz, Hongmei Zhu • EURASIP Journal on Advances in Signal Processing (2010)

Time-varying coherence is a powerful tool for revealing functional dynamics between different regions in the brain. In this paper, we address ways of estimating evolutionary spectrum and coherence using the general Cohen's class distrib...

DOAJ Open Access (DOAJ) DOI: 10.1155/2010/390910

Metabolic modeling-based drug repurposing in Glioblastoma

Claudio Tomi-Andrino, Alina Pandele, Klaus Winzer, John King et al. • Scientific Reports (2022)

Abstract The manifestation of intra- and inter-tumor heterogeneity hinders the development of ubiquitous cancer treatments, thus requiring a tailored therapy for each cancer type. Specifically, the reprogramming of cellular metabolism has b...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-022-14721-w

Molecular regionalization in the compact brain of the meiofaunal annelid Dinophilus gyrociliatus (Dinophilidae)

Alexandra Kerbl, José M. Martín-Durán, Katrine Worsaae, Andreas Hejnol • EvoDevo (2016)

Abstract Background Annelida is a morphologically diverse animal group that exhibits a remarkable variety in nervous system architecture (e.g., number and location of longitudinal cords, architecture of the brain). Despite this heterogeneit...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13227-016-0058-2