Academic Articles & Research Papers

Midbrain endocannabinoids actuate dopamine-based action selection

Summary: Quickly adapting behavior to changing environments is key for survival. Brain dopamine signals reinforce actions that procure rewards and avoid adverse outcomes. However, the molecular mechanisms within the circuits that actuate th...

Directed Evolution of Near-Infrared Serotonin Nanosensors with Machine Learning-Based Screening

In this study, we employed a novel approach to improve the serotonin-responsive ssDNA-wrapped single-walled carbon nanotube (ssDNA-SWCNT) nanosensors, combining directed evolution and machine learning-based prediction. Our iterative optimiz...

A Protein‐Centric Strategy Coupled with Match‐Between‐Run Glycoproteomics Enables Discovery of Robust Site‐Specific Glycan Biomarkers for Hepatocellular Carcinoma

ABSTRACT Dysregulated protein glycosylation is a hallmark of cancer, and systematic investigation of glycosylation patterns is crucial for identifying biomarkers. However, current glycoproteomic studies are constrained by the limited quanti...

Computer Vision-Based Assessment of Motor Functioning in Schizophrenia: Use of Smartphones for Remote Measurement of Schizophrenia Symptomatology

Introduction: Motor abnormalities have been shown to be a distinct component of schizophrenia symptomatology. However, objective and scalable methods for assessment of motor functioning in schizophrenia are lacking. Advancements in machine ...

Comparing Clinical Metadata Fusion Strategies for Diabetic and Hypertensive Retinopathy Classification

Structured clinical variables may complement fundus photographs, but the most appropriate point at which to integrate them into a retinal foundation model remains uncertain. This study compares an image-only baseline with three strategies f...

Identification and validation of CCL28 and CCL5 as chemokine biomarkers and pro-inflammatory mediators in acute pancreatitis: an integrated bioinformatics and experimental study.

The voice of depression: speech features as biomarkers for major depressive disorder

Abstract Background Psychiatry faces a challenge due to the lack of objective biomarkers, as current assessments are based on subjective evaluations. Automated speech analysis shows promise in detecting symptom severity in depressed patient...

Selection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learning

Despite the advances in surface-display systems for directed evolution, variants with high affinity are not always enriched due to undesirable biases that increase target-unrelated variants during biopanning. Here, our goal was to design a ...

Investigating the Role of Artificial Intelligence in Management of Diabetes in Iran: A Systematic Review

Background and Aim: Diabetes is one of the most common metabolic diseases in Iran and the fifth leading cause of death all over the world. Its spread around the world has created new methods in biomedical research, including artificial inte...

PERMEPSY: a multicentre, randomized, double-blind proof-of-concept trial of personalized metacognitive training for adults with psychosis — a study protocol

BackgroundWhile psychological interventions are effective at improving symptoms of psychosis, accessible, cost- and time-efficient treatments remain limited. Personalized medicine has emerged as a promising approach, tailoring interventions...

Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation

ABSTRACT Saikosaponin b1 (Ssb1), a natural oleanane‐type triterpenoid saponin, exhibits antifibrosis activity by inhibiting the activation of hepatic stellate cells (HSCs), but the specific underlying molecular mechanisms are unknown. Here,...

Integrated Multiomics Analysis Reveals Manual Therapy Restores Autophagic Homeostasis via the AMPK/ULK1 Axis in Chronic Low Back Pain

Precision Microalgae: A New Conceptual Framework for Bioengineering Applications

Microalgae are promising platforms for biomass production, carbon capture, biofuels, and high-value bioproducts. However, despite significant advances in cultivation technologies, reactor engineering, and metabolic engineering, industrial i...

Influencing Factors Associated With Infantile Hemangioma: A Case-Control Study Among Chinese Pediatric Populations.

Takotsubo syndrome diagnosis: the biomarker-based BioTAK score.

Application Research of Microstructured Flexible Sensors in Rehabilitative Wearable Sensing

ABSTRACT Flexible sensors enable the continuous, real‐time monitoring of the physiological and movement signals of patients, providing data support for precise rehabilitation strategies and playing a crucial role in rehabilitation medicine....

Artificial intelligence in pancreatic cancer

Pancreatic cancer is the deadliest disease, with a five-year overall survival rate of just 11%. The pancreatic cancer patients diagnosed with early screening have a median overall survival of nearly ten years, compared with 1.5 years for th...

Employing General-Purpose and Biomedical Large Language Models with Advanced Prompt Engineering for Pharmacoepidemiologic Study Design.

Pancreatic Islet Cell Hormones: Secretion, Function, and Diabetes Therapy

ABSTRACT The pancreatic islets of Langerhans, which are composed of α, β, δ, ε, and PP cells, orchestrate systemic glucose homeostasis through tightly regulated hormone secretion. Although the precise mechanisms involving β cells in the ons...

Ultrasound-Based Radiomics and Deep Learning for Prediction of Lateral and Central Lymph Node Metastasis and BRAF Gene Mutation in Papillary Thyroid Carcinoma.