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Receptor allostery promotes context-specific Sonic Hedgehog signaling during embryonic development

Miriam E. Dillard, Christina A. Daly, Rojalin Pradhan, Shariq S. Ansari et al. • Nature Communications (2026)

Abstract Sonic Hedgehog (SHH) signaling functions in temporal- and context-dependent manners to pattern diverse tissues during embryogenesis. The signal transducer Smoothened (SMO) is induced by sterols, oxysterols, and arachidonic acid (AA...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-026-75918-5

Lipid-mediated gating of a miniature mechanosensitive MscS channel from Trypanosoma cruzi

Jingying Zhang, Aashish Bhatt, Grigory Maksaev, Yun Lyna Luo et al. • Nature Communications (2025)

Abstract The mechanosensitive channel of small conductance (MscS) from E. coli (EcMscS) has served as the prevailing model system for understanding mechanotransduction in ion channels. Trypanosoma cruzi, the protozoan parasite causing Chaga...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-025-62757-z

Variation in TMEM106B in chronic traumatic encephalopathy

Jonathan D. Cherry, Jesse Mez, John F. Crary, Yorghos Tripodis et al. • Acta Neuropathologica Communications (2018)

Abstract The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodege...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40478-018-0619-9

PRIMUS: Comprehensive proteomics of mouse intervertebral discs that inform novel biology and relevance to human disease modelling

Mateusz Kudelko, Peikai Chen, Vivian Tam, Ying Zhang et al. • Matrix Biology Plus (2021)

Mice are commonly used to study intervertebral disc (IVD) biology and related diseases such as IVD degeneration. Discs from both the lumbar and tail regions are used. However, little is known about compartmental characteristics in the diffe...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.mbplus.2021.100082

Co-Regulation of Protein Coding Genes by Transcription Factor and Long Non-Coding RNA in SARS-CoV-2 Infected Cells: An In Silico Analysis

Chinmay Saha, Sayantan Laha, Raghunath Chatterjee, Nitai P. Bhattacharyya • Non-Coding RNA (2021)

Altered expression of protein coding gene (PCG) and long non-coding RNA (lncRNA) have been identified in SARS-CoV-2 infected cells and tissues from COVID-19 patients. The functional role and mechanism (s) of transcriptional regulation of de...

DOAJ Open Access (DOAJ) DOI: 10.3390/ncrna7040074

Technology-Supported Behavior Change—Applying Design Thinking to mHealth Application Development

Ramona Schweitzer, Stephan Schlögl, Marco Schweitzer • European Journal of Investigation in Health, Psychology and Education (2024)

Non-communicable diseases are the leading cause of global deaths. The risk of their development and progression is increased by modifiable behavioral risk factors. Yet, despite the known benefits of primary and secondary prevention, people ...

DOAJ Open Access (DOAJ) DOI: 10.3390/ejihpe14030039

Vehicular ad hoc networks verification scheme based on bilinear pairings and networks reverse fuzzy extraction

Zaid Ameen Abduljabbar, Vincent Omollo Nyangaresi, Ahmed Ali Ahmed, Junchao Ma et al. • Scientific Reports (2025)

Abstract Vehicular Ad-Hoc Networks (VANETs) have facilitated the massive exchange of real-time traffic and weather conditions, which have helped prevent collisions, reduce accidents, and road congestions. This can effectively enhance drivin...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-15011-x

Embracing AI-Based Education: Perceived Social Presence of Human Teachers and Expectations About Machine Teachers in Online Education

Jihyun Kim, Kelly Merrill Jr, Kun Xu, Deanna D. Sellnow • Human-Machine Communication Journal (2022)

Technological advancements in education have turned the idea of machines as teachers into a reality. To better understand this phenomenon, the present study explores how college students develop expectations (or anticipations) about a machi...

DOAJ Open Access (DOAJ) DOI: 10.30658/hmc.4.9

Highly efficient photonic PCR system based on plasmonic heating of gold nanofilms

Joshua Nabuti, Ahmed Rashad Fath Elbab, Ahmed Abdel-Mawgood, Matsushita Yoshihisa et al. • Biosensors and Bioelectronics: X (2023)

The polymerase chain reaction (PCR) is a standard molecular method that has the potential to solve the need for accurate, viable, and immediate infectious pathogen detection at point-of-care (POC) centers in different fields such as pathoge...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.biosx.2023.100346

The rank of contextuality

Karol Horodecki, Jingfang Zhou, Maciej Stankiewicz, Roberto Salazar et al. • New Journal of Physics (2023)

Quantum contextuality is one of the most recognized resources in quantum communication and computing scenarios. We provide a new quantifier of this resource, the rank of contextuality (RC). We define RC as the minimum number of non-contextu...

DOAJ Open Access (DOAJ) DOI: 10.1088/1367-2630/acdf78

Quantum Interference of Electromechanically Stabilized Emitters in Nanophotonic Devices

B. Machielse, S. Bogdanovic, S. Meesala, S. Gauthier et al. • Physical Review X (2019)

Photon-mediated coupling between distant matter qubits may enable secure communication over long distances, the implementation of distributed quantum computing schemes, and the exploration of new regimes of many-body quantum dynamics. Solid...

DOAJ Open Access (DOAJ) DOI: 10.1103/PhysRevX.9.031022