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Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer

Ruifang Li, Sara A. Grimm, Deepak Mav, Haiwei Gu et al. • Cell Reports (2018)

Colorectal cancer (CRC) tends to occur at older age; however, CRC incidence rates have been rising sharply among young age groups. The increasing prevalence of obesity is recognized as a major risk, yet the mechanistic underpinnings remain ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.celrep.2017.12.071

Encapsulation of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in liposomes prepared by thin film hydration and their transfer to mesenchymal stem cells and cord blood hematopoietic stem cells

Sławomir Lewicki, Monika Leśniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka et al. • Archives of Medical Science (2020)

Introduction Cytokines are important immune modulator factors controlling homeostasis of the body and are involved in tissue regeneration after wound healing. The encapsulation of cytokines in liposomes has many advantages potentially usefu...

DOAJ Open Access (DOAJ) DOI: 10.5114/aoms.2020.94527

Evidence of aberrant anti-epstein-barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue

Isobel C. Mouat, Li Zhu, Alperen Aslan, Barry W. McColl et al. • Journal of Inflammation (2024)

Abstract Background Fatigue is a common complication of stroke that has a significant impact on quality of life. The biological mechanisms that underly post-stroke fatigue are currently unclear, however, reactivation of latent viruses and t...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12950-024-00402-0

Genetic and Psychosocial Risk Factors Associated with Suicide Among Community Veterans: Implications for Screening, Treatment and Precision Medicine

Boscarino JA, Adams RE, Urosevich TG, Hoffman SN et al. • Pharmacogenomics and Personalized Medicine (2022)

Joseph A Boscarino,1 Richard E Adams,2 Thomas G Urosevich,3 Stuart N Hoffman,4 H Lester Kirchner,1 Xin Chu,5 Weixing Shi,5 Joseph J Boscarino,6 Ryan J Dugan,1 Carrie A Withey,1 Charles R Figley7 1Department Population Health Sciences, Geisi...

DOAJ Open Access (DOAJ)

Heme iron amplifies azoxymethane initiating effect on rat colon preneoplastic lesions

Julia Keller, Pascale Plaisancié, Edwin Fouché, Edwige-Marie Pralet et al. • Redox Experimental Medicine (2025)

Objective: Colorectal cancer is a major public health issue for which dietary factors such as red and processed meat consumption seem to play a prominent role. Heme iron, which is present in important concentration in those food products, w...

DOAJ Open Access (DOAJ) DOI: 10.1530/REM-25-0001

Atrial fibrillation signals associated with overactive bladder drugs across JADER and FAERS: disproportionality and time-to-onset analyses

Kyosuke Nagura, Satoko Watanabe, Taro Watanabe, Taro Watanabe et al. • Frontiers in Pharmacology (2026)

IntroductionOveractive bladder (OAB) drugs are widely prescribed, yet the occurrence of atrial fibrillation (AF) after treatment initiation remains poorly characterized.MethodsWe evaluated reports of AF associated with OAB medications using...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2025.1700587

Immunoediting in acute myeloid leukemia: Reappraising T cell exhaustion and the aberrant antigen processing machinery in leukemogenesis

Ching-Yun Wang, Shiuan-Chen Lin, Kao-Jung Chang, Han-Ping Cheong et al. • Heliyon (2024)

Acute myeloid leukemia (AML) establishes an immunosuppressive microenvironment that favors leukemic proliferation. The immune-suppressive cytokines altered antigen processing, and presentation collectively assist AML cells in escaping cytot...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2024.e39731

Comparative Outer Membrane Protein Analysis of High and Low-Invasive Strains of Cronobacter malonaticus

Maha A. Aldubyan, Maha A. Aldubyan, Ibtesam S. Almami, Ibtesam S. Almami et al. • Frontiers in Microbiology (2017)

Cronobacter are an important group of foodborne pathogens that has been linked to life-threatening infections in both infants and adults. The major infections associated with Cronobacter species are neonatal meningitis, necrotizing enteroco...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2017.02268

End-of-life decisions and involvement of Physical and Rehabilitation Medicine Physicians in Europe

Rutger Osterthun, Katharina Sunnerhagen, Henk J. Stam, Carlotte Kiekens • Journal of Rehabilitation Medicine (2023)

Objective: As Physical and Rehabilitation Medicine physicians are experts in functional prognoses of disabling health conditions, the aim of this study was to gain insight into their involvement in end-of-life decisions in patients with neu...

DOAJ Open Access (DOAJ) DOI: 10.2340/jrm.v55.5575

Neudesin is involved in anxiety behavior: structural and neurochemical correlates

Ashley eNovais, Ashley eNovais, Ana Catarina Ferreira, Ana Catarina Ferreira et al. • Frontiers in Behavioral Neuroscience (2013)

Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (mot...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnbeh.2013.00119

Perceived Intensity and Discrimination Ability for Lingual Electrotactile Stimulation Depends on Location and Orientation of Electrodes

Leslie M. Stone-Roy, Joel Moritz Jr., Philip Turk, John D. Williams • Frontiers in Human Neuroscience (2017)

Malfunctioning sensory systems can severely impact quality of life and repair is not always possible. One solution, called sensory substitution, is to use another sensory system to bring lost information to the brain. This approach often in...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnhum.2017.00186

Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish

Marjo J. den Broeder, Jarle Ballangby, Leonie M. Kamminga, Peter Aleström et al. • Epigenetics & Chromatin (2020)

Abstract Background Recent studies indicate that exposure to environmental chemicals may increase susceptibility to developing metabolic diseases. This susceptibility may in part be caused by changes to the epigenetic landscape which conseq...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13072-020-0329-y

Nuclear genomic signals of the ‘microturbellarian’ roots of platyhelminth evolutionary innovation

Christopher E Laumer, Andreas Hejnol, Gonzalo Giribet • eLife (2015)

Flatworms number among the most diverse invertebrate phyla and represent the most biomedically significant branch of the major bilaterian clade Spiralia, but to date, deep evolutionary relationships within this group have been studied using...

DOAJ Open Access (DOAJ) DOI: 10.7554/eLife.05503

Water mites (Acari, Hydrachnidia) of riparian springs in a small lowland river valley: what are the key factors for species distribution?

Andrzej Zawal, Robert Stryjecki, Edyta Buczyńska, Paweł Buczyński et al. • PeerJ (2018)

This paper examines the impact of disturbance factors—flooding and intermittency—on the distribution of water mites in the riparian springs situated in the valley of a small lowland river, the Krąpiel. The landscape factors and physicochemi...

DOAJ Open Access (DOAJ) DOI: 10.7717/peerj.4797

Improved Immunohistochemistry of Mouse Eye Sections Using Davidson's Fixative and Melanin Bleaching

Anne Longakit, Chloe Hess, Christina Zhang, Catherine Van Raamsdonk • Bio-Protocol (2025)

Immunohistochemistry (IHC) and immunofluorescence (IF) are fundamental molecular biology techniques to assess protein expression. However, the melanin present normally in the eye in the uveal tract (choroid, iris, and ciliary body) and the ...

DOAJ Open Access (DOAJ) DOI: 10.21769/BioProtoc.5510

Metabolomic Profile Alterations Associated with the SLC16A11 Risk Haplotype Following a Lifestyle Intervention in People With Prediabetes

Magdalena Sevilla-González, Maria Fernanda Garibay-Gutiérrez, Arsenio Vargas-Vázquez, Andrea Celeste Medina-García et al. • Current Developments in Nutrition (2024)

Background: A risk haplotype in SLC16A11 characterized by alterations in fatty acid metabolism emerged as a genetic risk factor associated with increased susceptibility to type 2 diabetes (T2D) in Mexican population. Its role on treatment r...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.cdnut.2024.104444