Academic Articles & Research Papers

Assessing Phase-Locked Repetitive Transcranial Magnetic Stimulation for Treatment of Parkinson’s and Essential Tremor

MRI Application in Quantification of Epiphyseal Development in the Wrist and Bone Age Estimation of Han Male Adolescents in East China

ObjectiveTo investigate the value of wrist MRI in bone age estimation for male adolescents in Shanghai, Zhejiang and Jiangsu.MethodsA total of 124 Han male adolescents aged 6.0 to 18.0 years from Shanghai, Zhejiang and Jiangsu were selected...

DETECTION & DIFFERENTIATION OF SOFT TISSUE INJURIES IN ADVANCE MAGNETIC RESONANCE IMAGING (MRI)

ABSTRACT BACKGROUND: Radiology is the application of the science of diagnostic imaging to questions of clinical and medicolegal practice. Forensic medicine refers to the application of medical knowledge in the collection of medical evidence...

Case report: Incidentally discovered case of pheochromocytoma as a cause of long COVID-19 syndrome

Pheochromocytomas (PCCs) are rare but potentially lethal tumors that arise from the adrenal medulla. The clinical suspicion and diagnosis of PCC can be challenging due to the non-specific nature of signs and symptoms. In many patients, infe...

TRACK-CF prospective cohort study: Understanding early cystic fibrosis lung disease

BackgroundLung disease as major cause for morbidity in patients with cystic fibrosis (CF) starts early in life. Its large phenotypic heterogeneity is partially explained by the genotype but other contributing factors are not well delineated...

HEALTH TECHNOLOGY DIFFUSION RATES

OBJECTIVE: To analyze the rates and influences on the adoption of three selected health technologies: statins, coronary stents, and magnetic resonance imaging (MRI). METHODS: A retrospective diffusion study using primary care prescribing da...

Treatment of Gluteal Tendinopathy: A Systematic Review and Stage-Adjusted Treatment Recommendation

Background: Gluteal tendinopathy is the most common lower limb tendinopathy. It presents with varying severity but may cause debilitating lateral hip pain. Purpose: To review the therapeutic options for different stages of gluteal tendinopa...

Simulators with Haptic Feedback in Neurosurgery: Are We Reaching the “Aviator” Type of Training? Narrative Review and Future Perspectives

Over the last decade, the quality of neurosurgical procedures dramatically improved, also thanks to the development and increased accessibility of several technological recourses (e.g., imaging, neuronavigation, neurophysiology, microscopy)...

Supporting the spread of health technology in community services

Health technology has been proposed as a route to financial savings and improved patient safety for many years within the NHS. Nurses have a key role to play in transforming care through such technology but, despite high-level endorsement, ...

Early disc degeneration in radiotherapy-treated childhood brain tumor survivors

Abstract Background Childhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity. This study aimed to investigate lumbar disc degenerat...

Positron emission tomography: establishing priorities for health technology assessment.

BACKGROUND: Positron emission tomography (PET) is an expensive diagnostic imaging technology. Despite the long history of PET development, the costs and effectiveness of its use in routine clinical practice remain unknown. Against this back...

Health Technologies as a Cost-Driver in Canada

This report describes our estimation of the effects of technological change (TC) on health care (HC) expenditures in Canada during the period 1996-2008. We focus on the effect of TC on overall nominal expenditures, as well as the effects of...

Preoperative and intraoperative assessment of myometrial invasion in patients with FIGO stage I non-endometrioid endometrial carcinoma—a large-scale, multi-center, and retrospective study

Abstract Introduction Myometrial invasion is a prognostic factor for lymph node metastases and decreased survival in non-endometrioid endometrial carcinoma patients. Herein, we explored the mode of myometrial invasion diagnosis in FIGO stag...

A Single Simulated Heliox Dive Modifies Endothelial Function in the Vascular Wall of ApoE Knockout Male Rats More Than Females

IntroductionThe number of divers is rising every year, including an increasing number of aging persons with impaired endothelial function and concomitant atherosclerosis. While diving is an independent modulator of endothelial function, lit...

Computable phenotype for real-world, data-driven retrospective identification of relapse in ANCA-associated vasculitis

Objective ANCA-associated vasculitis (AAV) is a relapsing-remitting disease, resulting in incremental tissue injury. The gold-standard relapse definition (Birmingham Vasculitis Activity Score, BVAS>0) is often missing or inaccurate in re...

Depressive phenotype shapes behavioral, neuroendocrine and molecular responses to repetitive transcranial magnetic stimulation in preclinical models of depression

IntroductionRepetitive transcranial magnetic stimulation (rTMS) is an established non-invasive treatment for treatment-resistant depression (TRD), yet its neurobiological mechanisms remain only partially understood. We investigated whether ...

Recent advances in benzo[a]phenoxazine-based fluorescent probes: a review and perspectives

Benzo[a]phenoxazine (BPO) based molecules have been recently emerged as a new class of near-infrared (NIR) fluorophore for image-guided diagnosis in cancer research. The successful application of BPOs as NIR fluorophore in biomedical resear...

Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved]

Background Breast cancer remains a significant global health concern, with early diagnosis and risk factor identification crucial for improving outcomes. Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) measurements...

Health technology and health technology assessment

In addition to the doctor, technology is an essential aspect of healthcare. In many parts of the world, a visit to the doctor does not feel complete without a prescription for a drug. Advanced laboratory and imaging technology is indispensa...

Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau

Mild cognitive impairment (MCI) can be an early manifestation of Alzheimer’s disease (AD) pathology, other pathologic entities [e.g., cerebrovascular disease, Lewy body disease, LATE (limbic-predominant age-related TDP-43 encephalopathy)], ...