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Showing 20 of 190 academic articles

Necroptosis and Neuroinflammation in Retinal Degeneration

Yan Tao, Yusuke Murakami, Demetrios G. Vavvas, Koh-Hei Sonoda • Frontiers in Neuroscience (2022)

Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated i...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2022.911430

Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold

Angelo Corti, Angelina Sacchi, Anna Maria Gasparri, Matteo Monieri et al. • Journal of Nanobiotechnology (2021)

Abstract Background Gold nanospheres tagged with peptides containing isoDGR (isoAsp-Gly-Arg), an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory cytokines to the tumor vasculature. We prepared bi- o...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-021-00871-y

CD36‐Binding Amphiphilic Nanoparticles for Attenuation of α‐Synuclein‐Induced Microglial Activation

Nanxia Zhao, Nicola L. Francis, Shuang Song, Vladyslav Kholodovych et al. • Advanced NanoBiomed Research (2022)

Neuroinflammation is one of the hallmarks contributing to Parkinson's disease (PD) pathology, where microglial activation occurs as one of the earliest events, triggered by extracellular α‐synuclein (aSYN) binding to the cluster of differen...

DOAJ Open Access (DOAJ) DOI: 10.1002/anbr.202100120

Curcumin: Reintroduced Therapeutic Agent from Traditional Medicine for Alcoholic Liver Disease

Hamid Reza Rahimi, Mahmoud Reza Jaafari, Amir Hooshang Mohammadpour, Khalil Abnous et al. • Asia Pacific Journal of Medical Toxicology (2015)

Alcoholic liver disease (ALD) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. The etiopathogenesis of ALD is related to ethanol-induced oxidative stress, glutathione reduction, abnormal me...

DOAJ Open Access (DOAJ) DOI: 10.22038/apjmt.2015.3983

Evidence for the Effectiveness of Remdesivir (GS-5734), a Nucleoside-Analog Antiviral Drug in the Inhibition of IK(M) or IK(DR) and in the Stimulation of IMEP

Wei-Ting Chang, Wei-Ting Chang, Wei-Ting Chang, Ping-Yen Liu et al. • Frontiers in Pharmacology (2020)

Remdesivir (RDV, GS-5734), a broad-spectrum antiviral drug in the class of nucleotide analogs, has been particularly tailored for treatment of coronavirus infections. However, to which extent RDV is able to modify various types of membrane ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2020.01091

YAP1 reactivation in cardiomyocytes following ECM remodelling contributes to the development of contractile force and sarcomere maturation

Vladimir Vinarsky, Stefania Pagliari, Bacel Aldabash, Fabiana Martino et al. • Cell Death Discovery (2025)

Abstract Cardiac diseases are fueled by extracellular matrix (ECM) remodelling. Together with the altered ECM chemical composition, the mechanical turmoil associated with ECM maladaptive remodelling in the pathological heart drives the shut...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41420-025-02793-2

Do Empathic Individuals Behave More Prosocially? Neural Correlates for Altruistic Behavior in the Dictator Game and the Dark Side of Empathy

Michael Schaefer, Anja Kühnel, Franziska Rumpel, Matti Gärtner • Brain Sciences (2021)

Do empathic individuals behave more prosocially? When we think of highly empathic individuals, we tend to assume that it is likely that those people will also help others. Most theories on empathy reflect this common understanding and claim...

DOAJ Open Access (DOAJ) DOI: 10.3390/brainsci11070863

Visual Context and Behavioral Priming in Pedestrian Crossing Decisions: Evidence from a Stated Preference Experiment in Ecuadorian Urban Areas

Yasmany García-Ramírez, Fernando Arrobo-Herrera, Alejandra Cruz-Cortez, Luis Fernández-Garrido et al. • Smart Cities (2026)

Pedestrian safety in developing countries faces critical challenges from rapid urbanization and infrastructure deficiencies. This study investigates how visual context influences pedestrian crossing preferences through a controlled stated p...

DOAJ Open Access (DOAJ) DOI: 10.3390/smartcities9010019

Behavior of Salmonella Typhimurium on Fresh Strawberries Under Different Storage Temperatures and Wash Treatments

Wen Wang, Yu Zhou, Yu Zhou, Xingning Xiao et al. • Frontiers in Microbiology (2018)

Fresh strawberries are one of the most popular fruits in China and are vulnerable to microbial contamination. In this study, the behavior of Salmonella Typhimurium on fresh strawberries stored at refrigeration and room temperatures, as well...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2018.02091

Cell-Based Sensors for the Detection of EGF and EGF-Stimulated Ca<sup>2+</sup> Signaling

Euiyeon Lee, Keshab Lal Shrestha, Seonhye Kang, Neethu Ramakrishnan et al. • Biosensors (2023)

Epidermal growth factor (EGF)-mediated activation of EGF receptors (EGFRs) has become an important target in drug development due to the implication of EGFR-mediated cellular signaling in cancer development. While various in vitro approache...

DOAJ Open Access (DOAJ) DOI: 10.3390/bios13030383

Application of biologically active substances in agriculture preparations

L. Krychkovska, M. Bobro, G. Birta, S. Karpushyna et al. • Рослинництво та ґрунтознавство (2025)

High-quality, naturally protected seeds prior to sowing, along with growth activation of seedlings, represent a promising approach to stabilising crop yield and quality. Enhancing plant resistance to dynamic environmental stresses, includin...

DOAJ Open Access (DOAJ) DOI: 10.31548/plant1.2025.09

Evaluation of Indicators for the Realization of the Development of Public-Oriented Urban Transportation (Study Case: District 11 of Tehran)

Sayyed Jalal Aldin Hosseini, Azita Rajabi, Afshin Safahan, Aliasghar Rezvani • برنامه‌ریزی توسعه شهری و منطقه‌ای (2024)

Transit-Oriented Development (TOD) represents a significant facet of sustainable urban planning aimed at addressing urban traffic challenges through the strategic expansion of public transportation systems. District 11 within the municipali...

DOAJ Open Access (DOAJ) DOI: 10.22054/urdp.2023.55092.1248

Case reports of latent HBV hepatitis in patients after neurosurgical treatment for hypothalamic and pituitary tumors

Kuniyasu Niizuma, Yoshikazu Ogawa, Takayuki Kogure, Teiji Tominaga • BMC Infectious Diseases (2020)

Abstract Background Hepatitis B virus (HBV) infection is a major public health problem worldwide. More than 2 billion people have been exposed to HBV, and about 257 million individuals are chronic carriers of HBV. HBV reactivation has been ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12879-020-04971-2

IL-10/STAT5 axis suppresses miR-140 to upregulate B7-H4 expression in RAW264.7 cells

Dandan Zhu, Guo Chen, Guo Chen, Pei Shen et al. • Frontiers in Cellular and Infection Microbiology (2025)

IntroductionSchistosomiasis japonica, a zoonotic parasitic disease, induces complex immune regulation during infection. The inflammatory responses and immunosuppressive mechanisms co-exist to maintain immune homeostasis in schistosomiasis. ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcimb.2025.1613297

Statistical Inter-stimulus Interval Window Estimation for Transient Neuromodulation via Paired Mechanical and Brain Stimulation

Euisun Kim, Waiman Meinhold, Minoru Shinohara, Jun Ueda • Frontiers in Neurorobotics (2020)

For achieving motor recovery in individuals with sensorimotor deficits, augmented activation of the appropriate sensorimotor system, and facilitated induction of neural plasticity are essential. An emerging procedure that combines periphera...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnbot.2020.00001

Quantum Computing in Cybersecurity

• Wiley eBooks (2023)

Machine learning, deep learning, probabilistic neural networks, blockchain, and other new technologies all demand extremely high processing speeds. A quantum computer is an example of such a system. Quantum computers may be accessed over th...

OPENALEX DOI: https://doi.org/10.1002/9781394167401

Fundus imaging based quantum computing: Grading of severity of vision threatening diabetic retinopathy

Amna Ikram, Azhar Imran • Informatics in Medicine Unlocked (2026)

Diabetic Retinopathy (DR) is a major complication of diabetes that can result in irreversible vision loss if not detected early. Manual ophthalmologic screening is time-consuming and subject to subjectivity, underscoring the need for accura...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.imu.2026.101744