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Grey matter volume associations with personality functioning in a clinical cohort of female youths

Madelyn Thomson, Marialuisa Cavelti, Ines Mürner-Lavanchy, Silvano Sele et al. • NeuroImage: Clinical (2026)

Borderline Personality Disorder (BPD) is a severe mental illness, although its neurobiological underpinnings remain largely unknown. Structural Magnetic Resonance Imaging (sMRI) in adolescents can offer insights into potential biomarkers to...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2026.103988

Contributions of childhood abuse and neglect to reward neural substrates in adolescence

Ruiyu Yang, Qiongru Yu, Cassidy Elizabeth Owen, Gabriele Ibarra Aspe et al. • NeuroImage: Clinical (2021)

Background: Childhood adverse experiences may come to bear particularly during adolescence, when neural reward systems are developing rapidly and psychopathology spikes. Despite prior work differentiating threat- (abuse) vs. deprivation- (n...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2021.102832

Data describing the poor outcome associated with a breast cancer diagnosis in the post-weaning period

Hanne Lefrère, Giuseppe Floris, Marjanka K. Schmidt, Patrick Neven et al. • Data in Brief (2021)

Postpartum breast cancer (PPBC) - which according to new data, can extend to 5–10 years after the birth - are estimated to represent 35–55% of all cases of breast cancer in women younger than 45 years. Increasing clinical evidence indicates...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.dib.2021.107354

Determinants of Health-Related Quality of Life in Schizophrenia: Beyond the Medical Model

Madeline W. Z. Lim, Jimmy Lee, Jimmy Lee, Jimmy Lee • Frontiers in Psychiatry (2018)

Background: Improving Quality of Life (QoL) in Schizophrenia is an important treatment objective in the shift toward person-centered and recovery-oriented care. Health-Related Quality of Life (HRQoL) is a focused aspect of QoL that is direc...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpsyt.2018.00712

Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation

Akihiro Sugai, Taisuke Kato, Akihide Koyama, Yuka Koike et al. • Neurobiology of Disease (2019)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by accumulation of fragmented insoluble TDP-43 and loss of TDP-43 from the nucleus. Increased expression of exogenous TARDBP (encoding TDP-43) induces TDP-43 p...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nbd.2019.104534

Early childhood household instability, adolescent structural neural network architecture, and young adulthood depression: A 21-year longitudinal study

Felicia A. Hardi, Leigh G. Goetschius, Scott Tillem, Vonnie McLoyd et al. • Developmental Cognitive Neuroscience (2023)

Unstable and unpredictable environments are linked to risk for psychopathology, but the underlying neural mechanisms that explain how instability relate to subsequent mental health concerns remain unclear. In particular, few studies have fo...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.dcn.2023.101253

The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis

Sebastian Makuch, Kamil Więcek, Marta Woźniak • Pharmaceuticals (2021)

Rheumatoid arthritis (RA) is a widespread chronic autoimmune disorder affecting the joints, causing irreversible cartilage, synovium, and bone degradation. During the course of the disease, many immune and joint cells are activated, causing...

DOAJ Open Access (DOAJ) DOI: 10.3390/ph14040309

Gamma-irradiated SARS-CoV-2 vaccine candidate, OZG-38.61.3, confers protection from SARS-CoV-2 challenge in human ACEII-transgenic mice

Raife Dilek Turan, Cihan Tastan, Derya Dilek Kancagi, Bulut Yurtsever et al. • Scientific Reports (2021)

Abstract The SARS-CoV-2 virus caused the most severe pandemic around the world, and vaccine development for urgent use became a crucial issue. Inactivated virus formulated vaccines such as Hepatitis A and smallpox proved to be reliable appr...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-021-95086-4

CD36‐Binding Amphiphilic Nanoparticles for Attenuation of α‐Synuclein‐Induced Microglial Activation

Nanxia Zhao, Nicola L. Francis, Shuang Song, Vladyslav Kholodovych et al. • Advanced NanoBiomed Research (2022)

Neuroinflammation is one of the hallmarks contributing to Parkinson's disease (PD) pathology, where microglial activation occurs as one of the earliest events, triggered by extracellular α‐synuclein (aSYN) binding to the cluster of differen...

DOAJ Open Access (DOAJ) DOI: 10.1002/anbr.202100120

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

Chih-Yang Huang, Chia-Hua Kuo, Pei-Ying Pai, Tsung-Jung Ho et al. • Data in Brief (2018)

In association with the published article “Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy” (Huang et al., 2017) [1], this data article contains information about deSUMOylat...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.dib.2017.11.040

The antibiogram of Pus cultures in Federal Tertiary Care Hospital, Islamabad and its utility in antimicrobial stewardshipThe antibiogram of pus cultures in federal tertiary care hospital, Islamabad and its utility in antimicrobial stewardship

Farhan Kursheed, Asraar Tabassum, Umme Farwa, Samia Wazir et al. • Iranian Journal of Microbiology (2024)

Background and Objectives: Antimicrobial resistance has emerged as a significant global health threat. Infections caused by Multi Drug-Resistant (MDR) bacteria pose formidable challenges in terms of treatment options and patient outcomes. P...

DOAJ Open Access (DOAJ) DOI: 10.18502/ijm.v16i1.14871

Reimbursement Legislations and Decision Making for Orphan Drugs in Central and Eastern European Countries

Krzysztof Piotr Malinowski, Paweł Kawalec, Wojciech Trąbka, Marcin Czech et al. • Frontiers in Pharmacology (2019)

BackgroundReimbursement policies influence access of patients to orphan drugs in the European countries.ObjectivesTo provide a comprehensive description of orphan drug reimbursement policies and to assess reimbursement decision-making proce...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2019.00487

Epstein–Barr Virus-Induced Metabolic Rearrangements in Human B-Cell Lymphomas

Pier P. Piccaluga, Pier P. Piccaluga, Pier P. Piccaluga, Alessandra Weber et al. • Frontiers in Microbiology (2018)

Tumor metabolism has been the object of several studies in the past, leading to the pivotal observation of a consistent shift toward aerobic glycolysis (so-called Warburg effect). More recently, several additional investigations proved that...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2018.01233

Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine

Amoolya Kandettu, Divya Adiga, Vasudha Devi, Padmanaban S. Suresh et al. • Genes and Diseases (2022)

Ovarian cancer (OC) is one of the most common and fatal types of gynecological cancer. OC is usually detected at the advanced stages of the disease, making it highly lethal. miRNAs are single-stranded, small non-coding RNAs with an approxim...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.gendis.2021.12.026

Differences in Genetic Background Contribute to Pseudomonas Exotoxin A-Induced Hepatotoxicity in Rats

Chien-Chao Chiu, Yu-Chih Wang, Wen-Ching Huang, Yi-Hsun Chen et al. • Toxins (2017)

Pseudomonas aeruginosa exotoxin A (PEA) causes severe hepatotoxicity in experimental animals and is useful in investigations of immune-mediated liver injury. However, strain differences in the sensitivity to PEA-induced hepatotoxicity in ra...

DOAJ Open Access (DOAJ) DOI: 10.3390/toxins9070224

Targeting ferroptosis to rescue osteogenic differentiation in BRONJ-affected jawbone mesenchymal stem cells: the role of miR-145-3p and exosome-mediated therapy

Yi Shuai, Bo Chen, Tao Jiang, Lei Zhu et al. • Journal of Nanobiotechnology (2025)

Abstract Background Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe, therapy-refractory condition driven by ferroptotic disruption of jawbone-derived mesenchymal stem cells (MSCs) biology. We dissect this mechanism to va...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03745-9

Poly (ADP-ribose) Polymerase Promoter Hypermethylation Predispose Females to Breast Cancer

Hussein Sabit, Shaimaa Nazir, Shimaa Abdel-Ghany, Osama A. Said et al. • Asian Pacific Journal of Cancer Biology (2019)

Being the most common cause of female deaths worldwide, breast cancer (BC) is intensively studied over the last two decades. In the present investigation, we evaluated the promoter methylation of three cancer-related genes; PARP-1, p21, and...

DOAJ Open Access (DOAJ) DOI: 10.31557/apjcb.2019.4.1.1-5