Academic Articles & Research Papers

Depressive phenotype shapes behavioral, neuroendocrine and molecular responses to repetitive transcranial magnetic stimulation in preclinical models of depression

IntroductionRepetitive transcranial magnetic stimulation (rTMS) is an established non-invasive treatment for treatment-resistant depression (TRD), yet its neurobiological mechanisms remain only partially understood. We investigated whether ...

Correction: Aging, the microbiota–gut–brain axis, and late-life epilepsy: a hypothesis-driven review

Clinical and cost-effectiveness of a standardised diagnostic assessment for children and adolescents with emotional difficulties: the STADIA multi-centre RCT

Background Emotional disorders are common in children and young people and can significantly impair their quality of life. Evidence-based treatments require a timely and appropriate diagnosis. The utility of standardised diagnostic assessme...

Delirium in Patients with Severe COVID-19: Preliminary Results of the MAPA Longitudinal Study

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Disrupted Functional Connectivity of Cornu Ammonis Subregions in Amnestic Mild Cognitive Impairment: A Longitudinal Resting-State fMRI Study

Background: The cornu ammonis (CA), as part of the hippocampal formation, represents a primary target region of neural degeneration in amnestic mild cognitive impairment (aMCI). Previous studies have revealed subtle structural deficits of t...

Online peer support for Young Onset Dementia is a promising resource, but not a panacea: a commentary from the INTERDEM Young Onset Dementia taskforce

The thalamus and its subregions – a gateway to obsessive-compulsive disorder

Introduction Higher thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population (Boedhoe et al. 2017, Weeland et al. 2021a). Functionally distin...

Dopamine transporter binding in symptomatic controls and healthy volunteers: Considerations for neuroimaging trials

Objective: To evaluate possible differences between brain dopamine transporter (DAT) binding in a group of symptomatic parkinsonism patients without dopaminergic degeneration and healthy individuals. Background: Dopaminergic neuroimaging st...

Penetration and familiarity of false belief on neuroscience among students and its modifiability

In Study 1, the degrees of penetration and familiarity of false belief on neuroscience, especially brain imaging, among students were surveyed using a questionnaire technique. A total number of 485 students from medical school, school of nu...

From Connectivity to Controllability: Unraveling the Brain Biomarkers of Major Depressive Disorder

Major Depressive Disorder (MDD) is a significant neurological condition associated with aberrations in brain functional networks. Traditional studies have predominantly analyzed these from a network topology perspective. However, given the ...

Modulation of frontal gamma oscillations improves working memory in schizophrenia

Schizophrenia is a debilitating mental disorder that is associated with cognitive deficits. Impairments in cognition occur early in the course of illness and are associated with poor functional outcome, but have been difficult to treat with...

A real-world clinical validation for AI-based MRI monitoring in multiple sclerosis

Abstract Modern management of MS targets No Evidence of Disease Activity (NEDA): no clinical relapses, no magnetic resonance imaging (MRI) disease activity and no disability worsening. While MRI is the principal tool available to neurologis...

Correction: Five-year dementia prediction and decision support system based on real-world data

Neural substrates of motor and cognitive dysfunctions in SCA2 patients: A network based statistics analysis

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease characterized by a progressive cerebellar syndrome, which can be isolated or associated with extracerebellar signs. It has been shown that patients affe...

Prenatal to postnatal trajectory of brain growth in complex congenital heart disease

Altered brain development is a common feature of the neurological sequelae of complex congenital heart disease (CHD). These alterations include abnormalities in brain size and growth that begin prenatally and persist postnatally. However, t...

NeuroDiag: Software for Automated Diagnosis of Parkinson’s Disease Using Handwriting

Objective: A change in handwriting is an early sign of Parkinson’s disease (PD). However, significant inter-person differences in handwriting make it difficult to identify pathological handwriting, especially in the early stages. Thi...

Using the consolidated framework for implementation research to guide a pilot of implementing an institution level patient informed consent process for clinical research at an outpatient setting

Abstract Background In Singapore, research teams seek informed patient consent on an ad hoc basis for specific clinical studies and there is typically a role separation between operational and research staff. With the enactment of the Human...

Designing and Evaluation of Reliability and Validity of Visual Cue-Induced Craving Assessment Task for Methamphetamine Smokers

A B S T R A C TIntroduction: Craving to methamphetamine is a significant health concern and exposure to methamphetamine cues in laboratory can induce craving. In this study, a task designing procedure for evaluating methamphetamine cue-indu...

Correlation of Social Network Attributes with Individuals’ Score on Bipolar Spectrum Diagnostic Scale

Introduction: Bipolar Spectrum Disorders include a variety of mood disorders from bipolar II disorder to conditions characterized by hyperthymic mood states. It has been suggested that psychosocial factors also play an important role in bip...

The Effect of APOE ɛ4 on the Functional Connectivity in Frontoparietal Network in Hypertensive Patients

Allele 4 of the apolipoprotein E gene (APOE ε4) and hypertension are considered risk factors for Alzheimer’s Disease (AD). The detection of differences in cognitive function and brain networks between hypertensive patients who are APOE ε4 c...