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Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson’s Disease: Comparative Analysis of G2019S and I1371V Variants

Khushboo Singh, Roon Banerjee, Chandrakanta Potdar, Anisha Shaw et al. • Cells (2026)

Mutations in leucine-rich repeat kinase 2 (LRRK2) are among the most common genetic causes of Parkinson’s disease (PD), yet substantial heterogeneity exists among pathogenic variants. How mutations in distinct functional domains of LRRK2 di...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells15040342

Effects of the Brazilian Native Fruit Jaboticaba (<i>Plinia cauliflora</i>) Peel on Inflammatory and Oxidative Stress Pathways: Insights from a Pilot Study in Hemodialysis Patients and Renal Cell Models

Ligia Soares Lima, Jessyca Sousa de Brito, Marcelo Ribeiro-Alves, Karen Salve Coutinho-Wolino et al. • Foods (2025)

Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory an...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods14234030

Assessment of Safety and Probiotic Traits of Enterococcus durans OSY-EGY, Isolated From Egyptian Artisanal Cheese, Using Comparative Genomics and Phenotypic Analyses

Walaa E. Hussein, Walaa E. Hussein, Ahmed G. Abdelhamid, Ahmed G. Abdelhamid et al. • Frontiers in Microbiology (2020)

An Enterococcus durans strain, designated OSY-EGY, was previously isolated from artisanal cheese. In this work, comparative genomic and phenotypic analyses were utilized to assess the safety characteristics and probiotic traits of the bacte...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2020.608314

Atorvastatin suppresses high-risk colorectal adenomas via reprogramming of lipid metabolism and Inhibition of stemness

Wentong Chen, Mengxiao Ge, Shuangyi Sun, Hanxiao Zhang et al. • Scientific Reports (2025)

Abstract As critical precursors to colorectal cancer (CRC), high-risk colorectal adenomas (HR-CRAs) lack effective chemopreventive strategies beyond endoscopic resection. We previously established a standardized protocol for culturing patie...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-32406-y

Investigating the performance of the fluorescent sensor g-C3N4/Fe/Cu in detecting the Tenofovir drug

Nafiseh Hajian Afarani, Fatemeh Keshavarzi, Kahin Shahanipour, Seyed Amir Zarei • Scientific Reports (2025)

Abstract Tenofovir is an antiviral drug that prevents the replication of AIDS and hepatitis B viruses. To minimize the harmful side effects of the drug on the body, it is essential to determine its precise concentration in the blood. Fluore...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-08877-4

Sex-based estimation of biological variation in plasma-free amino acid concentrations among healthy adults

Müjgan Ercan, Emiş Deniz Akbulut, Ayşen Caniklioğlu, Esra Fırat Oğuz et al. • Journal of Mass Spectrometry and Advances in the Clinical Lab (2025)

Introduction: Free amino acid (FAA) analysis plays a crucial role in diagnosing and monitoring inborn errors of metabolism, assessing nutritional status, and identifying metabolic imbalances associated with various diseases. This study aime...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jmsacl.2025.04.010

Zooarqueología de una unidad doméstica Formativa: El caso de Loma Alta (Catamarca, Argentina) Zooarchaeology of a Formative domestic unit: The case of Loma Alta (Catamarca, Argentina)

Andrés Darío Izeta, María Cristina Scattolin • Intersecciones en Antropología (2006)

El propósito de este trabajo es el de aportar datos e interpretaciones de la economía de una unidad doméstica de un sitio del Período Formativo del noroeste argentino (Loma Alta Núcleo E) relacionada con el manejo de camélidos. El registro ...

DOAJ Open Access (DOAJ)

The song of air and water: Acoustic experiments with an Ecuadorian Whistle Bottle (c.900 BC–100 BC)

Mónica Amparo Ayala Esparza, Galo Fernando Gallardo Carrillo, Miguel Molina-Alarcón • Internet Archaeology (2019)

In Ecuador, bottles as containers for liquids appeared in the Late Formative period at the end of the Machalilla culture (1600 BC to 800 BC). Whistle bottles were created and perfected during the Chorrera culture (900 BC to 100 BC), and fin...

DOAJ Open Access (DOAJ) DOI: 10.11141/ia.52.2

Lie similarity analysis of MHD Casson fluid flow with heat source and variable viscosity over a porous stretching sheet

Thenmozhi D, M. Eswara Rao, Ch. Nagalakshmi, RLV.Renuka Devi et al. • International Journal of Thermofluids (2024)

The current study presents a novel examination of heat transfer properties in a magnetohydrodynamic (MHD) flow of Casson fluid across a porous stretching sheet, uniquely incorporating the effects of heat source and variable viscosity. Unlik...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ijft.2024.100804

Ranking of treatments in network meta-analysis: incorporating minimally important differences

Tristan Curteis, Augustine Wigle, Christopher J. Michaels, Adriani Nikolakopoulou • BMC Medical Research Methodology (2025)

Abstract Background In network meta-analysis (NMA), the magnitude of difference between treatment effects is typically ignored in the calculation of ranking metrics, such as probability best and surface under the cumulative ranking curve (S...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12874-025-02499-0

Research on the Quality Variation Patterns During the Fermentation Process of Coffee-Grounds Craft Beer

Jiashun Jiang, Jingan Yang, Tong Zhu, Yongjin Hu et al. • Foods (2025)

To investigate the metabolic differences and mechanisms during the fermentation process of coffee-grounds craft beer, HS-SPME-GC/MS untargeted metabolomics technology was used to study the metabolic differences during the fermentation proce...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods14061014

Effects of supplementing sweet sorghum with grapeseeds on carcass parameters, and meat quality, amino acid, and fatty acid composition of lambs

Jianxin Jiao, Ting Wang, Shanshan Li, Nana Gou et al. • Animal Bioscience (2023)

Objective Sweet sorghum is an important forage crop for ruminants, especially in low rainfall areas. Grapeseeds are an abundant by-product of wine-making and contain bioactive substances that can improve the antioxidant capacity of meat. We...

DOAJ Open Access (DOAJ) DOI: 10.5713/ab.22.0189

PESTS ASSOCIATED WITH STORED WHEAT AT SHARKIA GOVERNORATE

Fatma Zourob, Karam Teleb, Zeinab Elbasheir, farg Mohamed • Journal of Productivity and Development (2019)

The present work was surveyed pests found in wheat grain and wheat flour of Sharkia   Governorate in four districts namely, (Bilbeis, Minya El Qamh, Alsalhea and Zagazig) during two years 2016-2017. The Sitophilus granaries was abundant in ...

DOAJ Open Access (DOAJ) DOI: 10.21608/jpd.2019.48167

Side Effects of Some Cotton Pesticides on the Dominant Spider Families in Cotton Fields

El-Sayed Hamada • Acarines: Journal of the Egyptian Society of Acarology (2016)

Survey was carried out at Elgemmeza  Agricultural Research Station in  a Colton field  for  Piacing sucking pests and associated predators along two successive seasons (2013 &amp; 2014) during May-August months by using examination of leave...

DOAJ Open Access (DOAJ) DOI: 10.21608/ajesa.2016.164144

Fluid-Solid Interaction Analysis of a Flow Passing Cylinder Based on Variational Mode Decomposition

Zuo Yaju, Fang Mingkun, Zhu Di, Lu Jiahao et al. • E3S Web of Conferences (2024)

The fluid-structure interaction problem of cylindrical flow around the cylinder is a classic problem, especially in many fields such as energy engineering, fluid dynamics, engineering structure, energy utilization and development, and envir...

DOAJ Open Access (DOAJ) DOI: 10.1051/e3sconf/202452001017

Determination of the cost-benefit efficient interval for sponge city construction by a multi-objective optimization model

Changmei Liang, Changmei Liang, Changmei Liang, Changmei Liang et al. • Frontiers in Environmental Science (2023)

The cost-benefit is a key factor when selecting an appropriate sponge city construction scheme. The research of applying intelligent technology to find cost-benefit efficient planning and construction of sponge city is urgently required. Th...

DOAJ Open Access (DOAJ) DOI: 10.3389/fenvs.2022.1072505

Capillary‐Driven Backflow During Salt Precipitation in a Rough Fracture

Xu‐Sheng Chen, Ran Hu, Chen‐Xing Zhou, Yang Xiao et al. • Water Resources Research (2024)

Abstract Salt precipitation is a crucial process occurring during CO2 injection into saline aquifers. It significantly alters the porous space, leading to reduced permeability and impaired injectivity. While the dynamics of precipitation ha...

DOAJ Open Access (DOAJ) DOI: 10.1029/2023WR035451

Experimental Study on the Effect of the Angle of Attack on the Flow-Induced Vibration of a Harbor Seal’s Whisker

Yuhan Wei, Chunning Ji, Dekui Yuan, Liqun Song et al. • Fluids (2023)

A harbor seal’s whisker is able to sense the trailing vortices of marine organisms due to its unique three-dimensional wavy shape, which suppresses the vibrations caused by its own vortex-shedding, while exciting large-amplitude and synchro...

DOAJ Open Access (DOAJ) DOI: 10.3390/fluids8070206

Thoracic electrical impedance tomography identifies heterogeneity in lungs associated with respiratory disease in cattle. A pilot study

Olivia Brabant, Yuliya V. Karpievitch, Yuliya V. Karpievitch, Alphons Gwatimba et al. • Frontiers in Veterinary Science (2024)

Respiratory disease in cattle is a significant global concern, yet current diagnostic methods are limited, and there is a lack of crush-side tests for detecting active disease. To address this gap, we propose utilizing electrical impedance ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fvets.2023.1275013