Academic Articles & Research Papers

Atrial fibrillation signals associated with overactive bladder drugs across JADER and FAERS: disproportionality and time-to-onset analyses

IntroductionOveractive bladder (OAB) drugs are widely prescribed, yet the occurrence of atrial fibrillation (AF) after treatment initiation remains poorly characterized.MethodsWe evaluated reports of AF associated with OAB medications using...

Study of the state of readiness of pharmaceutical institutions of Ukraine for implementation of integrated quality systems

One of the most promising ways to increase the efficiency of pharmaceutical enterprises in the field of quality assurance of medicines is the introduction of integrated quality systems (IQS). The aim of the work is to study of the state ...

Corrigendum to “Metabolic risk factors in first acute coronary syndrome (MERIFACS) study” [Indian Heart J 2022 Jul–Aug;74(4):275–281]

Incidence of suicidality in people with depression over a 10-year period treated by a large UK mental health service provider

We describe the incidence of suicidality (2007–2017) in people with depression treated by secondary mental healthcare services at South London and Maudsley NHS Trust (n = 26 412). We estimated yearly incidence of ‘suicidal ideation’ and ‘hi...

Variation in TMEM106B in chronic traumatic encephalopathy

Abstract The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodege...

Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish

Abstract Background Recent studies indicate that exposure to environmental chemicals may increase susceptibility to developing metabolic diseases. This susceptibility may in part be caused by changes to the epigenetic landscape which conseq...

Metabolomic Profile Alterations Associated with the SLC16A11 Risk Haplotype Following a Lifestyle Intervention in People With Prediabetes

Background: A risk haplotype in SLC16A11 characterized by alterations in fatty acid metabolism emerged as a genetic risk factor associated with increased susceptibility to type 2 diabetes (T2D) in Mexican population. Its role on treatment r...

The Genetic Architecture of Murine Glutathione Transferases.

Glutathione S-transferase (GST) genes play a protective role against oxidative stress and may influence disease risk and drug pharmacokinetics. In this study, massive multiscalar trait profiling across a large population of mice derived fro...

Genetics of breast cancer: Applications to the Mexican population

Breast cancer research has yielded several important results including the strong susceptibility genes,BRCA1 and BRCA2 and more recently 19 genes and genetic loci that confer a more moderate risk.The pace of discovery is accelerating as gen...

Meta-analysis of MitraClip and PASCAL for transcatheter mitral edge-to-edge repair

Abstract Background Despite the promising results of both MitraClip and PASCAL systems for the treatment of mitral regurgitation (MR), there is limited data on the comparison of both systems regarding their safety and efficacy. We aim to co...

Causal analysis between altered levels of interleukins and obstructive sleep apnea

BackgroundInflammation proteins including interleukins (ILs) have been reported to be related to obstructive sleep apnea (OSA). The aims of this study were to estimate the levels for several key interleukins in OSA and the causal effects be...

Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure

Glaucoma is a leading cause of blindness, affecting up to 70 million people worldwide. High intraocular pressure (IOP) is a major risk factor for glaucoma. It is well established that inefficient aqueous humor (AqH) outflow resulting from s...

Family and community resilience: a Photovoice study

Abstract Background Adverse childhood experiences (ACEs), in combination with adverse community environments, can result in traumatic stress reactions, increasing a person’s risk for chronic physical and mental health conditions. Family res...

Management of Ureters Involved in Inguinal Hernias

Background: The presence of a ureter in a hernia sac presents a unique surgical challenge and can increase the likelihood of ureteral injury at the time of surgery as they are often not identified pre-operatively. Here we present our instit...

Technology-Supported Behavior Change—Applying Design Thinking to mHealth Application Development

Non-communicable diseases are the leading cause of global deaths. The risk of their development and progression is increased by modifiable behavioral risk factors. Yet, despite the known benefits of primary and secondary prevention, people ...

Analysing interventions designed to reduce tuberculosis-related stigma: A scoping review.

Stigma is a critical barrier for TB care delivery; yet data on stigma reduction interventions is limited. This review maps the available literature on TB stigma reduction interventions, using the Health Stigma and Discrimination framework a...

Critical Cybersecurity Scenarios in Drinking Water Treatment Plants

The increasing interconnectivity with external networks and the higher reliance on digital systems make chemical and process industries, including waste and drinking water treatment plants, more vulnerable to cyber-attacks. Historical evide...

SIMULATION OF INFORMATION SECURITY RISKS OF AVAILABILITY OF PROJECT DOCUMENTS BASED ON FUZZY LOGIC

The widespread use of computer technology, its rapid development and use in almost all areas of human activity requires constant updating of information security issues. The activities of many enterprises in the field of IT, construction, a...

Artificial intelligence in clinical medicine: a state-of-the-art overview of systematic reviews with methodological recommendations for improved reporting

Medicine has become increasingly receptive to the use of artificial intelligence (AI). This overview of systematic reviews (SRs) aims to categorise current evidence about it and identify the current methodological state of the art in the fi...

Classifying Characteristics of Opioid Use Disorder From Hospital Discharge Summaries Using Natural Language Processing

BackgroundOpioid use disorder (OUD) is underdiagnosed in health system settings, limiting research on OUD using electronic health records (EHRs). Medical encounter notes can enrich structured EHR data with documented signs and symptoms of O...