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Showing 20 of 1,732 academic articles

Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma

Zelin Tian, Chen Xu, Peijun Yang, Zhibin Lin et al. • Frontiers in Immunology (2022)

Hepatocellular carcinoma(HCC) is the sixth most common cancer in the world and is usually caused by viral hepatitis (HBV and HCV), alcoholic, and non-alcoholic fatty liver disease(NAFLD). Viral hepatitis accounts for 80% of HCC cases worldw...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2022.984728

Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives

Yao Li, Qiu Chen, Tingting Wang, Zengkai Ji et al. • Journal of Nanobiotechnology (2025)

Abstract As the prevalence of metabolic diseases such as diabetes and obesity continue to rise, the search for more effective and convenient treatments has become a crucial issue in medical research. Microneedles (MNs), as an innovative dru...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03432-9

Persistent Endothelial Dysfunction in Post-Acute COVID-19 Syndrome: A Case-Control Study

Pasquale Ambrosino, Ilenia Calcaterra, Antonio Molino, Pasquale Moretta et al. • Biomedicines (2021)

Background: Endothelial dysfunction has a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its disabling complications. We designed a case-control study to assess the alterations of endothelium-dependent flow-mediated...

DOAJ Open Access (DOAJ) DOI: 10.3390/biomedicines9080957

Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold

Angelo Corti, Angelina Sacchi, Anna Maria Gasparri, Matteo Monieri et al. • Journal of Nanobiotechnology (2021)

Abstract Background Gold nanospheres tagged with peptides containing isoDGR (isoAsp-Gly-Arg), an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory cytokines to the tumor vasculature. We prepared bi- o...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-021-00871-y

Computational Tools; Indispensable Armamentarium of Medical Biotechnology

Nutan, Swapnil Jain, K Shilpa, Akanksha Tomar et al. • Indian Journal of Science and Technology (2016)

Objective: Computational infrastructure of medical biotechnology provides insight into elements of genomics, proteomics for understanding diseases and biological systems in a more comprehensive and systematic way. The present study exclusiv...

OPENALEX cc-by DOI: https://doi.org/10.17485/ijst/2016/v9i32/100745

Calliphoridae Flies in Medical Biotechnology

A. Yu. Yakovlev, Anastasia A. Kruglikova, Sergey I. Chernysh • Entomological Review (2019)

Blow flies (Diptera, Calliphoridae) and their medical applications have attracted the attention of biologists and doctors for more than a century. The best known is the use of “surgical maggots” in the treatment of infected wounds and ulcer...

OPENALEX DOI: https://doi.org/10.1134/s0013873819030023

Convergent Adaptation in the Dominant Global Hospital Clone ST239 of Methicillin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>

Sarah L. Baines, Kathryn E. Holt, Mark B. Schultz, Torsten Seemann et al. • mBio (2015)

ABSTRACT Infections caused by highly successful clones of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) are a major public health burden. The globally dominant sequence type 239 (ST239) HA-MRSA clone has persiste...

DOAJ Open Access (DOAJ) DOI: 10.1128/mBio.00080-15

Gamma-irradiated SARS-CoV-2 vaccine candidate, OZG-38.61.3, confers protection from SARS-CoV-2 challenge in human ACEII-transgenic mice

Raife Dilek Turan, Cihan Tastan, Derya Dilek Kancagi, Bulut Yurtsever et al. • Scientific Reports (2021)

Abstract The SARS-CoV-2 virus caused the most severe pandemic around the world, and vaccine development for urgent use became a crucial issue. Inactivated virus formulated vaccines such as Hepatitis A and smallpox proved to be reliable appr...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-021-95086-4

Formation and stability of oil-in-water nanoemulsions containing rice bran oil: <it>in vitro </it>and <it>in vivo </it>assessments

Rocha-Filho Pedro A, Oliveira Gustavo C, Viera Gisely S, Bortoloto Josiane et al. • Journal of Nanobiotechnology (2011)

Abstract Background Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice bran oil in sunscreen formulations, anti ageing prod...

DOAJ Open Access (DOAJ) DOI: 10.1186/1477-3155-9-44

CD36‐Binding Amphiphilic Nanoparticles for Attenuation of α‐Synuclein‐Induced Microglial Activation

Nanxia Zhao, Nicola L. Francis, Shuang Song, Vladyslav Kholodovych et al. • Advanced NanoBiomed Research (2022)

Neuroinflammation is one of the hallmarks contributing to Parkinson's disease (PD) pathology, where microglial activation occurs as one of the earliest events, triggered by extracellular α‐synuclein (aSYN) binding to the cluster of differen...

DOAJ Open Access (DOAJ) DOI: 10.1002/anbr.202100120

Genetic signatures of exceptional longevity: a comprehensive analysis of coding region single nucleotide polymorphisms (SNPs) in centenarians and supercentenarians

Audre Preena Maria Sundar Raj, Gayathri Selvakumar, James Clement, George M. Church et al. • Human Genomics (2025)

Abstract Aging, a complex biological process, entails sequential changes in organisms that elevate the risk of frailty, disease, and mortality, affecting individuals at the level of cellular, organ, and organism. This process is influenced ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40246-025-00772-3

Antibody response after pneumococcal vaccination in a large cohort of Italian children and adolescents with Down syndrome

Antonio Musolino, Marco Roversi, Mariateresa Romaniello, Vittorio Scoppola et al. • Vaccine: X (2025)

Introduction: Pneumococcal vaccination has significantly decreased the burden of invasive pneumococcal disease in the general population, however studies on effectiveness in Down syndrome (DS) are heterogeneous. In this cross-sectional stud...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jvacx.2025.100744

The Advancement of Medical Biotechnology in Developing Countries: Economic Opportunities and Challenges

Jiawen Chen • Highlights in Business Economics and Management (2023)

Starting from decades ago, medical biotechnology has revolutionized the healthcare industry by offering new hopes for previously untreatable diseases and improving overall health outcomes. To explore the advancements in medical biotechnolog...

OPENALEX cc-by-nc DOI: https://doi.org/10.54097/45c92q28

Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms

Xiao Wang, Wenxuan Shi, Yu Jin, Zhuoyuan Li et al. • Journal of Nanobiotechnology (2025)

Abstract The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03126-2