Academic Articles & Research Papers

Cosmic muon flux attenuation methods for superconducting qubit experiments

We propose and demonstrate two practical mitigation methods to attenuate the cosmic muon flux, compatible with experiments involving superconducting qubits: shallow underground sites and device orientation. Using a specifically-built cosmic...

CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling

Abstract Background Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (H...

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury

Objectives and Aims: Vascular smooth muscle cells (VSMCs) are key constituents of both normal arteries and atherosclerotic plaques. They have an ability to adapt to changes in the local environment by undergoing phenotypic modulation. An im...

Molecular monitoring of insecticide resistance in major disease vectors in Armenia

Abstract Background Armenia is considered particularly vulnerable to life-threatening vector-borne diseases (VBDs) including malaria, West Nile virus disease and leishmaniasis. However, information relevant for the control of the vectors of...

Unrevealing the dual role of paired box and sex determining region Y related high mobility group box in glioblastoma

Abstract This narrative review summarises glioblastoma (GBM), a very frequent invasive kind of brain tumour in the elderly that is extremely aggressive, resistant to treatment, and has a bad prognosis because of its substantial genetic and ...

Extracellular vesicles derived from mesenchymal stromal cells mitigate intestinal toxicity in a mouse model of acute radiation syndrome

Abstract Background Human exposure to high doses of radiation resulting in acute radiation syndrome and death can rapidly escalate to a mass casualty catastrophe in the event of nuclear accidents or terrorism. The primary reason is that the...

Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster

Circadian clocks are highly conserved transcriptional regulators that control ~24 hr oscillations in gene expression, physiological function, and behavior. Circadian clocks exist in almost every tissue and are thought to control tissue-spec...

Information theory in molecular biology

Glycosylation of Epigallocatechin Gallate by Engineered Glycoside Hydrolases from <i>Talaromyces amestolkiae</i>: Potential Antiproliferative and Neuroprotective Effect of These Molecules

Glycoside hydrolases (GHs) are enzymes that hydrolyze glycosidic bonds, but some of them can also catalyze the synthesis of glycosides by transglycosylation. However, the yields of this reaction are generally low since the glycosides formed...

Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth

Tazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential as a promising therapeutic agent for treating melanoma in situ. Its primary mechanism o...

The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism underlying the ULK complex assembly have yet to be ...

Transgenerational inheritance of ethanol preference is caused by maternal NPF repression

Rapid or even anticipatory adaptation to environmental conditions can provide a decisive fitness advantage to an organism. The memory of recurring conditions could also benefit future generations; however, neuronally-encoded behavior isn’t ...

Targeting Inflammation With Nanosized Drug Delivery Platforms in Cardiovascular Diseases: Immune Cell Modulation in Atherosclerosis

Atherosclerosis (AS) is a disorder of large and medium-sized arteries; it consists in the formation of lipid-rich plaques in the intima and inner media, whose pathophysiology is mostly driven by inflammation. Currently available interventio...

Nanotechnology and medicine

Nanotechnology, or systems/device manufacture at the molecular level, is a multidisciplinary scientific field undergoing explosive development. The genesis of nanotechnology can be traced to the promise of revolutionary advances across medi...

Macrophage USF2 Lactylation-Mediated FABP4 Suppression Promotes Intracellular Proliferation of Brucella.

A ROADMAP FOR A COMPUTATIONAL THEORY OF THE VALUE OF INFORMATION IN ORIGIN OF LIFE QUESTIONS

Information plays a critical role in complex biological systems. Complex systems like immune systems and ant colonies co-ordinate heterogeneous components in a decentralized fashion. How do these distributed decentralized systems function? ...

Adaptive Diagnosis in Distributed Systems

Real-time problem diagnosis in large distributed computer systems and networks is a challenging task that requires fast and accurate inferences from potentially huge data volumes. In this paper, we propose a cost-efficient, adaptive diagnos...

Three-Dimensional Physical and Optical Characteristics of Aerosols over Central China from Long-Term CALIPSO and HYSPLIT Data

Aerosols greatly influence global and regional atmospheric systems, and human life. However, a comprehensive understanding of the source regions and three-dimensional (3D) characteristics of aerosol transport over central China is yet to be...

Virtual Time and Global States of Distributed Systems

A distributed system can be characterized by the fact that the global state is distributed and that a common time base does not exist. However, the notion of time is an important concept in every day life of our decentralized "real world" a...

Psychometric facets of Antifragility: Tolerance of Ambiguity, Hardiness, and Growth

This paper considers the issues, which are concerned with a new concept of antifragility. Quite recently, considerable attention has been paid to the concept of antifragility. Antifragility gains a special importance in studying psychologic...