Academic Articles & Research Papers

Small cell neuroendocrine carcinoma of the cervix: From molecular basis to therapeutic advances

Small cell neuroendocrine carcinoma of the cervix (SCNECC) is an uncommon but aggressive uterine malignancy, the cause of which is generally associated with human papillomavirus (HPV) infection. A lack of clinical trials and evidence-based ...

PRIMUS: Comprehensive proteomics of mouse intervertebral discs that inform novel biology and relevance to human disease modelling

Mice are commonly used to study intervertebral disc (IVD) biology and related diseases such as IVD degeneration. Discs from both the lumbar and tail regions are used. However, little is known about compartmental characteristics in the diffe...

Nuclear genomic signals of the ‘microturbellarian’ roots of platyhelminth evolutionary innovation

Flatworms number among the most diverse invertebrate phyla and represent the most biomedically significant branch of the major bilaterian clade Spiralia, but to date, deep evolutionary relationships within this group have been studied using...

Metabolomic Profile Alterations Associated with the SLC16A11 Risk Haplotype Following a Lifestyle Intervention in People With Prediabetes

Background: A risk haplotype in SLC16A11 characterized by alterations in fatty acid metabolism emerged as a genetic risk factor associated with increased susceptibility to type 2 diabetes (T2D) in Mexican population. Its role on treatment r...

Establishment of Biocontrol Agents and Their Impact on Rhizosphere Microbiome and Induced Grapevine Defenses Are Highly Soil-Dependent

With a reduction in available chemical treatments, there is an increased interest in biological control of grapevine trunk diseases. Few studies have investigated the impact of introducing beneficial microorganisms in the rhizosphere on the...

Single Eye mRNA-Seq Reveals Normalisation of the Retinal Microglial Transcriptome Following Acute Inflammation

Background: Whether retinal microglia can maintain or restore immune homeostasis during and after inflammation is unclear. We performed single-eye mRNA-sequencing on microglia at different timepoints following a single inflammatory stimulus...

High posterior tibial slope increases anterior cruciate ligament elongation in unicompartmental knee arthroplasty during early-flexion of lunge

Abstract Background In-silico and in-vitro studies have revealed an appropriate posterior tibial slope (PTS) is critical for normal anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) tension and knee biomechanical behavi...

Effects of Lactobacillus crispatus-Containing Probiotics and Metformin on Insulin Resistance, Inflammation, and Gut Microbiome in Polycystic Ovary Syndrome: Protocol for an Open-Label Randomized Controlled Trial.

Identification and reporting of heart failure with preserved ejection fraction in Sub-Saharan Africa: a scoping review of diagnostic approaches, echocardiographic assessment, and evidence gaps

Abstract Background Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized as a major heart failure phenotype globally; however, its diagnosis is complex and is recommended to require integrated assessment of clin...

Biohybrid Actuators for Soft Robotics: Challenges in Scaling Up

Living systems have evolved to survive in a wide range of environments and safely interact with other objects and organisms. Thus, living systems have been the source of inspiration for many researchers looking to apply their mechanics and ...

Large datasets of water vapor sorption, mass diffusion immersed in water, hygroscopic expansion and mechanical properties of flax fibre/shape memory epoxy hygromorph composites

This data article presents four experimental sets of results related to flax fibre composites with epoxy shape memory polymer matrix: water vapor absorption, mass diffusion immersed in water, hygroscopic expansion, mechanical properties. Th...

Soft Pneumatic Bending Actuator with Integrated Carbon Nanotube Displacement Sensor

The excellent compliance and large range of motion of soft actuators controlled by fluid pressure has lead to strong interest in applying devices of this type for biomimetic and human-robot interaction applications. However, in contrast to ...

Reinforcement learning with learned gadgets to tackle hard quantum problems on real hardware

Abstract Quantum computing offers exciting opportunities for simulating complex quantum systems and optimizing large-scale combinatorial problems, but its practical use is limited by device noise and constrained connectivity. Designing quan...

Circulating and extracellular vesicle-associated non-coding RNAs in diabetic retinopathy: a stage-aware framework for network-informed biomarker panels.

Non-Echocardiographic Evaluation of Hypertrophic Cardiomyopathy.

Artificial intelligence in clinical medicine: a state-of-the-art overview of systematic reviews with methodological recommendations for improved reporting

Medicine has become increasingly receptive to the use of artificial intelligence (AI). This overview of systematic reviews (SRs) aims to categorise current evidence about it and identify the current methodological state of the art in the fi...

Classifying Characteristics of Opioid Use Disorder From Hospital Discharge Summaries Using Natural Language Processing

BackgroundOpioid use disorder (OUD) is underdiagnosed in health system settings, limiting research on OUD using electronic health records (EHRs). Medical encounter notes can enrich structured EHR data with documented signs and symptoms of O...

Exploring language learning and corrective feedback in an eTandem project

Many studies about eTandem and language learning stem from learners in Western institutions of higher education. Unfortunately, there is a lack of research investigating the telecollaboration regarding language development between learners ...

A bibliometric analysis of natural language processing in medical research

BACKGROUND: Natural language processing (NLP) has become an increasingly significant role in advancing medicine. Rich research achievements of NLP methods and applications for medical information processing are available. It is of great sig...

Natural Language Processing in Health Care and Biomedicine