Academic Articles & Research Papers

Early Retinal Microvascular Alterations in Young Type 1 Diabetic Patients without Clinical Retinopathy

The purpose of this study is to identify and quantify preclinical changes with the help of optical coherence tomography angiography (OCTA) within the retinal microcirculation of young type 1 diabetes (T1D) patients without clinical signs of...

Exploring feature selection and classification methods for predicting heart disease

Machine learning has been used successfully to improve the accuracy of computer-aided diagnosis systems. This paper experimentally assesses the performance of models derived by machine learning techniques by using relevant features chosen b...

Datasets describing hydrogel properties and cellular metrics for modeling of tumor dormancy

Breast cancer dormancy is an underlying challenge toward targeting and controlling metastatic recurrence and disease progression. Development of engineered, well-defined in vitro models is necessary to systematically recapitulate tumor dorm...

A novel and accelerated method for integrated alignment and variant calling from short and long reads

BackgroundIntegrating short- and long-read sequencing technologies has become a promising approach for achieving accurate and comprehensive genomic analysis. Although short-read sequencing (Illumina, etc.) offers high base accuracy and cost...

Medical Informatics in Medical Research

OBJECTIVES: Computers are widely used for data management in clinical trials in the developed countries, unlike in developing countries. Dependable systems are vital for data management, and medical decision making in clinical research. Mon...

Medical Informatics and the Concept of Disease

Trends in Proportion of Delirium Among Older Emergency Department Patients in South Korea, 2017–2022

Introduction: Delirium is a critical neuropsychiatric condition that surged among older adults during the coronavirus disease 2019 (COVID-19) pandemic, likely due to social isolation resulting from distancing measures. In this study we exam...

eHealth for Addressing Balance Disorders in the Elderly: Systematic Review

BackgroundThe population is aging on a global scale, triggering vulnerability for chronic multimorbidity, balance disorders, and falls. Falls with injuries are the main cause of accidental death in the elderly population, representing a rel...

Lessons From a Rapid Project Management Exercise in the Time of Pandemic: Methodology for a Global COVID-19 VIRUS Registry Database

BackgroundThe rapid emergence of the COVID-19 pandemic globally collapsed health care organizations worldwide. Incomplete knowledge of best practices, progression of disease, and its impact could result in fallible care. Data on symptoms an...

Lifestyle Change Interventions for Children and Adolescents With Diabetes or Kidney Disease

The purpose of this research letter is to report on the availability of evidence-based interventions for promoting lifestyle change in children and adolescents with diabetes or kidney disease. References for this review were obtained using ...

A real-world clinical validation for AI-based MRI monitoring in multiple sclerosis

Abstract Modern management of MS targets No Evidence of Disease Activity (NEDA): no clinical relapses, no magnetic resonance imaging (MRI) disease activity and no disability worsening. While MRI is the principal tool available to neurologis...

Income and education predict elevated depressive symptoms in the general population: results from the Gutenberg health study

Abstract Background Socioeconomic status (SES) has a strong association with depression or physical and mental health in general. However, as SES is a multifaceted construct these associations are not easy to explain. Further, there are sev...

Medical Informatics and eHealth

Medical Informatics comprises the theoretical and practical aspects of information processing and communication, based on knowledge and experience derived from processes in medicine and healthcare. The processing takes place within computer...

A Focus on Simulation in Medical Informatics

This special issue of JAMIA addresses simulation, a methodology that holds great promise for the advancement of information technology in health care. Simulation has been termed a third domain, complementing both natural language and mathem...

The History and New Trends of Medical Informatics

ABSTRACT The breakthrough of the computer and information technologies in all the segments of the society, led to the needs for the computer and information technologies. The knowledge of information technology is now part of general litera...

Role of the Internet in Solving the Last Mile Problem in Medicine

Internet-augmented medicine has a strong role to play in ensuring that all populations benefit equally from discoveries in the medical sciences. Yet, data from the Centers for Disease Control and Prevention collected from 1999 to 2014 sugge...

Central vein sign: A diagnostic biomarker in multiple sclerosis (CAVS-MS) study protocol for a prospective multicenter trial

The specificity and implementation of current MRI-based diagnostic criteria for multiple sclerosis (MS) are imperfect. Approximately 1 in 5 of individuals diagnosed with MS are eventually determined not to have the disease, with overrelianc...

Multi-label classification of fundus images based on graph convolutional network

Abstract Background Diabetic Retinopathy (DR) is the most common and serious microvascular complication in the diabetic population. Using computer-aided diagnosis from the fundus images has become a method of detecting retinal diseases, but...

Health-related quality of life in Chinese population with non-alcoholic fatty liver disease: a national multicenter survey

Abstract Background Health Related Quality of Life (HRQL) is a multi-dimensional construct that can comprehensively evaluate the patient’s health status, including physical, emotional, mental and social well-being. In this study, we aimed t...

Requirements for Vitiligo Registry Design in Iran: A Qualitative Content Analysis Study

Background: Vitiligo is a prevalent skin disorder that has significant biological and social consequences for the affected individuals. Therefore, appropriate measures should be taken to diagnose this disease and treat patients, and powerfu...