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Soil Geochemical Properties Influencing the Diversity of Bacteria and Archaea in Soils of the Kitezh Lake Area, Antarctica

Qinxin Li, Nengfei Wang, Wenbing Han, Botao Zhang et al. • Biology (2022)

It is believed that polar regions are influenced by global warming more significantly, and because polar regions are less affected by human activities, they have certain reference values for future predictions. This study aimed to investiga...

DOAJ Open Access (DOAJ) DOI: 10.3390/biology11121855

Emerging mutations in envelope protein of SARS-CoV-2 and their effect on thermodynamic properties

Kejie Mou, Mohnad Abdalla, Dong Qing Wei, Muhammad Tahir Khan et al. • Informatics in Medicine Unlocked (2021)

Structural proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are potential drug targets due to their role in the virus life cycle. The envelope (E) protein is one of the structural proteins; plays a critical role in v...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.imu.2021.100675

High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa

Yan Yang, Xue Li, Lang Sun, Xiu-Kun Wang et al. • Microbiology Spectrum (2025)

ABSTRACT Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global threat, but the mechanism of non-carbapenemase carbapenem resistance is still unclear. In the current study, we investigated the contributions of point mutations in mex...

DOAJ Open Access (DOAJ) DOI: 10.1128/spectrum.01398-24

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

Chih-Yang Huang, Chia-Hua Kuo, Pei-Ying Pai, Tsung-Jung Ho et al. • Data in Brief (2018)

In association with the published article “Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy” (Huang et al., 2017) [1], this data article contains information about deSUMOylat...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.dib.2017.11.040

Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia

Chih-Hsiang Yu, Ya-Hsuan Chang, Der-Shiun Wang, Shiann-Tarng Jou et al. • Scientific Reports (2023)

Abstract Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, espec...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-023-27720-2

Isolation, characterization, and genomic analysis of a novel phage WSPA with lytic activity against Serratia marcescens

Lijuan Li, Kunkun Li, Yu Mi, Xiumei Wu et al. • Microbiology Spectrum (2025)

ABSTRACT Serratia marcescens is an established pathogen implicated in hospital-acquired infections and is notorious for its propensity to form biofilms on medical devices, leading to persistent environmental contamination and increased infe...

DOAJ Open Access (DOAJ) DOI: 10.1128/spectrum.02716-24

Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases

Lateef Adegboyega Sulaimon, Lukman Olalekan Afolabi, Rahmat Adetutu Adisa, Akinrinade George Ayankojo et al. • Advances in Redox Research (2022)

The Mitochondria is a critical sub-cellular organelle that plays an integral part in a normal cellular process. Besides ATP production, the mitochondria participate in various key cellular processes such as cell signaling, epigenetic regula...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.arres.2022.100037

Evidence for the Effectiveness of Remdesivir (GS-5734), a Nucleoside-Analog Antiviral Drug in the Inhibition of IK(M) or IK(DR) and in the Stimulation of IMEP

Wei-Ting Chang, Wei-Ting Chang, Wei-Ting Chang, Ping-Yen Liu et al. • Frontiers in Pharmacology (2020)

Remdesivir (RDV, GS-5734), a broad-spectrum antiviral drug in the class of nucleotide analogs, has been particularly tailored for treatment of coronavirus infections. However, to which extent RDV is able to modify various types of membrane ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2020.01091

Differences in Genetic Background Contribute to Pseudomonas Exotoxin A-Induced Hepatotoxicity in Rats

Chien-Chao Chiu, Yu-Chih Wang, Wen-Ching Huang, Yi-Hsun Chen et al. • Toxins (2017)

Pseudomonas aeruginosa exotoxin A (PEA) causes severe hepatotoxicity in experimental animals and is useful in investigations of immune-mediated liver injury. However, strain differences in the sensitivity to PEA-induced hepatotoxicity in ra...

DOAJ Open Access (DOAJ) DOI: 10.3390/toxins9070224

A Novel Prognostic Scoring Model for Myelodysplastic Syndrome Patients With SF3B1 Mutation

Liya Ma, Bin Liang, Huixian Hu, Wenli Yang et al. • Frontiers in Oncology (2022)

The outcomes of myelodysplastic syndrome (MDS) patients with SF3B1 mutation, despite identified as a favorable prognostic biomarker, are variable. To comprehend the heterogeneity in clinical characteristics and outcomes, we reviewed 140 MDS...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2022.905490

Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy

Wei Liu, Yan Xu, Yi Wang, Lugui Qiu et al. • Journal for ImmunoTherapy of Cancer (2024)

Background Over 50% of patients with relapsed or refractory large B-cell lymphoma (r/r LBCL) receiving CD19-targeted chimeric antigen receptor (CAR19) T-cell therapy fail to achieve durable remission. Early identification of relapse or prog...

DOAJ Open Access (DOAJ) DOI: 10.1136/jitc-2023-008450

Prenatal diagnosis of mosaicism for double aneuploidy of 47,XXY and trisomy 7 (48,XXY,+7) at amniocentesis in a pregnancy with a favorable outcome

Chih-Ping Chen, Hsiu-Ting Tsai, Schu-Rern Chern, Peih-Shan Wu et al. • Taiwanese Journal of Obstetrics & Gynecology (2021)

Objective: We present prenatal diagnosis of mosaicism for double aneuploidy of 47, XXY and trisomy 7 (48,XXY,+7) at amniocentesis in a pregnancy with a favorable outcome. Case report: A 33-year-old woman underwent amniocentesis at 17 weeks ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.tjog.2021.03.029

Symbolic CSR and public responses among young Chinese social media users: dual mediation of skepticism and trust, moderated by algorithmic ethical perception

Tian Zhang, Tao Song, Muhammad Zaiamri Zainal Abidin, Mumtaz Aini Alivi • Frontiers in Communication (2026)

Drawing on signaling theory and the cognitive-affective framework, this study developed a moderated serial mediation model to explain how perceived symbolic CSR is associated with public responses in algorithm-mediated environments. It exam...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcomm.2026.1717505

Modeling and analysis for dynamical Doppler shifts on terahertz communication signals propagating in inhomogeneous hypersonic plasma sheath

Xiangmeng Lin, Junyi Zhang, Kai Yuan, Ziyang Zhao et al. • AIP Advances (2025)

Previous studies have shown that terahertz (THz) signals could penetrate hypersonic plasma sheaths. Thus, it is considered to be a potential solution to the “blackout” problem. Nevertheless, although previous studies have systematically rev...

DOAJ Open Access (DOAJ) DOI: 10.1063/5.0281985

Evaluating Urban–Rural Disparity of Public Facilities Provision in Chengdu–Chongqing: An Equity Index Approach with Multi-Source Data

Xuan Liu, Youxin Qian, Guohui Zhou, Guangyu Xu et al. • Systems (2026)

Urban–rural public facility disparity is a systemic challenge that reflects dysfunctional feedback loops within and across social and technical subsystems. Traditional administrative-unit-based analyses cannot capture such systemic alignmen...

DOAJ Open Access (DOAJ) DOI: 10.3390/systems14080903