Reset
Showing 20 of 2,514 academic articles

Structural Design, Synthesis and Antioxidant, Antileishmania, Anti-Inflammatory and Anticancer Activities of a Novel Quercetin Acetylated Derivative

Saul Vislei Simões da Silva, Orlando Maia Barboza, Jéssica Teles Souza, Érica Novaes Soares et al. • Molecules (2021)

Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water, extensive enzymatic metabolism and a reduced bioavailability limit its biopharmacological use. The aim of this study was to perform structural mod...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules26226923

Proteomic analysis of synergetic neuroprotective effect of adenosine, thiamine, niacin and cyanocobalamin in pathophysiology of diabetic polyneuropathy

O. A. Gromova, I. Yu. Torshin, A. G. Moiseenok • Фармакоэкономика (2025)

Background. Neurotransmitter adenosine and B-group vitamins have neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect ...

DOAJ Open Access (DOAJ) DOI: 10.17749/2070-4909/farmakoekonomika.2024.285

Assessment of Safety and Probiotic Traits of Enterococcus durans OSY-EGY, Isolated From Egyptian Artisanal Cheese, Using Comparative Genomics and Phenotypic Analyses

Walaa E. Hussein, Walaa E. Hussein, Ahmed G. Abdelhamid, Ahmed G. Abdelhamid et al. • Frontiers in Microbiology (2020)

An Enterococcus durans strain, designated OSY-EGY, was previously isolated from artisanal cheese. In this work, comparative genomic and phenotypic analyses were utilized to assess the safety characteristics and probiotic traits of the bacte...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2020.608314

RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis.

Brianna Dufek, Daniel T Meehan, Duane Delimont, Kevin Wilhelm et al. • PLoS ONE (2020)

Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels o...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0237907

CD56-Negative Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Study in 443 Patients Treated by Chemotherapy With or Without Asparaginase

Jing Yang, Pengfei Li, Pengfei Li, Pengfei Li et al. • Frontiers in Immunology (2022)

ObjectiveExtranodal natural killer/T cell lymphoma (NKTCL) is an aggressive EBV-related lymphoma, originating from NK cells or T cells. Previous study demonstrated that CD56 negative NKTCL should be recognized as a distinct subtype. In this...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2022.829366

Multi-Cohort Transcriptomics Combined with Mendelian Randomization Identifies PPARGC1A, NAAA and GIPC2 as NLRP3 Inflammasome-Related Key Genes in Ulcerative Colitis

Cheng J, Huang Y • Journal of Inflammation Research (2026)

Jian Cheng, Yangfeng Huang Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, School of Medicine,University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of ChinaCorrespond...

DOAJ Open Access (DOAJ)

Atorvastatin suppresses high-risk colorectal adenomas via reprogramming of lipid metabolism and Inhibition of stemness

Wentong Chen, Mengxiao Ge, Shuangyi Sun, Hanxiao Zhang et al. • Scientific Reports (2025)

Abstract As critical precursors to colorectal cancer (CRC), high-risk colorectal adenomas (HR-CRAs) lack effective chemopreventive strategies beyond endoscopic resection. We previously established a standardized protocol for culturing patie...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-32406-y

Constraining PERMANOVA and LDM to within-set comparisons by projection improves the efficiency of analyses of matched sets of microbiome data

Zhengyi Zhu, Glen A. Satten, Caroline Mitchell, Yi-Juan Hu • Microbiome (2021)

Abstract Background Matched-set data arise frequently in microbiome studies. For example, we may collect pre- and post-treatment samples from a set of individuals, or use important confounding variables to match data from case participants ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40168-021-01034-9

Spray dried inulin–sodium carboxymethylcellulose microcarriers with solid-to-colloidal transition: Development for foliar delivery of polyphenol-rich extract

Rita Patrizia Aquino, Teresa Mencherini, Pierluigi Mazzei, Tiziana Esposito et al. • Carbohydrate Polymer Technologies and Applications (2025)

This study reports on the development of a carbohydrate-based spray-dried microparticulate system (F-CHES) conceived for the stabilization and foliar delivery of polyphenol-rich plant extracts for sustainable phyto defense applications. Che...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.carpta.2025.101023

Sex-based estimation of biological variation in plasma-free amino acid concentrations among healthy adults

Müjgan Ercan, Emiş Deniz Akbulut, Ayşen Caniklioğlu, Esra Fırat Oğuz et al. • Journal of Mass Spectrometry and Advances in the Clinical Lab (2025)

Introduction: Free amino acid (FAA) analysis plays a crucial role in diagnosing and monitoring inborn errors of metabolism, assessing nutritional status, and identifying metabolic imbalances associated with various diseases. This study aime...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jmsacl.2025.04.010

3D Printing parameter optimisation combined with heat treatment for achieving high density and enhanced performance in refractory high-entropy alloys

Deyu Jiang, Miao Luo, Changxi Liu, Yashuo Zhang et al. • Virtual and Physical Prototyping (2025)

In this study, a Ti1.5Nb1Ta0.5Zr1Mo0.5 (TNTZM) high-entropy alloy was fabricated using laser powder bed fusion (LPBF). By integrating 63 sets of parameter trials with machine learning (ML) models, an optimised process window was identified,...

DOAJ Open Access (DOAJ) DOI: 10.1080/17452759.2025.2524524

The Biomechanical Characteristics of Swallowing in Tracheostomized Patients with Aspiration following Acquired Brain Injury: A Cross-Sectional Study

Xiao-Xiao Han, Jia Qiao, Zhan-Ao Meng, Dong-Mei Pan et al. • Brain Sciences (2023)

Objectives: Investigate the biomechanical characteristics in tracheostomized patients with aspiration following acquired brain injury (ABI) and further explore the relationship between the biomechanical characteristics and aspiration. Metho...

DOAJ Open Access (DOAJ) DOI: 10.3390/brainsci13010091

All-dielectric metaoptics for the compact generation of double-ring perfect vector beams

Vogliardi Andrea, Ruffato Gianluca, Bonaldo Daniele, Dal Zilio Simone et al. • Nanophotonics (2023)

Perfect vortices, whose ring profile is independent of the topological charge, play a key role in telecommunications and particle micro-manipulation. In this work, we report the compact generation of a new kind of double-ring perfect vortic...

DOAJ Open Access (DOAJ) DOI: 10.1515/nanoph-2023-0555

Enhanced Absorption with Graphene-Coated Silicon Carbide Nanowires for Mid-Infrared Nanophotonics

Patrick Rufangura, Iryna Khodasevych, Arti Agrawal, Matteo Bosi et al. • Nanomaterials (2021)

The mid-infrared (MIR) is an exciting spectral range that also hosts useful molecular vibrational fingerprints. There is a growing interest in nanophotonics operating in this spectral range, and recent advances in plasmonic research are aim...

DOAJ Open Access (DOAJ) DOI: 10.3390/nano11092339

To Be or Not to Be: Alicante-8, a Cluster or Not?

Randa Asa’d, V. D. Ivanov, I. Negueruela, J. M John et al. • The Astronomical Journal (2023)

Recent surveys have uncovered new young massive clusters that host dozens of red supergiants (RSGs) near the inner Galaxy. However, many of them have still not been fully studied. Using Very Large Telescope/X-shooter near-infrared spectra, ...

DOAJ Open Access (DOAJ) DOI: 10.3847/1538-3881/acc841

So FAIR, so good

Rinaldi Lorenzo, Bonacorsi Daniele, Bozzi Concezio, Dal Pra Stefano et al. • EPJ Web of Conferences (2025)

Large international collaborations in the field of Nuclear and Subnuclear Physics have been leading the implementation of FAIR principles for managing research data. These principles are essential when dealing with large volumes of data ove...

DOAJ Open Access (DOAJ) DOI: 10.1051/epjconf/202533701140