Academic Articles & Research Papers

Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro

Colorectal carcinoma (CRC) is one of the most common malignancies, though there are no effective therapeutic regimens at present. This study aimed to investigate the inhibitory effects of mannooligosaccharides extracted from coconut meal (C...

Add-On Selective Estrogen Receptor Modulators for Methadone Maintenance Treatment

Methadone maintenance treatment (MMT) remains the cornerstone for the management of opiate abuse. However, MMT can be associated with complex factors, including complications during the tolerance phase, the inability of some patients to mai...

Effects of an infant formula containing a whey protein concentrate on feeding tolerance and markers of intestinal immune defense in Chinese infants

Abstract Background Human milk (HM) bioactive components can have immune modulatory functions, impact the gut microbiome, and may result in functional benefits when added to infant formula (IF). In this single-arm, prospective, intervention...

Changes in the nonlinear and viscoelastic mechanical properties of the rat lamina cribrosa under chronic high intraocular pressure

IntroductionThe lamina cribrosa (LC) in the optic nerve head is the initial site of glaucomatous optic nerve injury. Under high intraocular pressure (IOP), the deformation of the LC compresses the retinal ganglion cell (RGC) axons passing t...

Preparation and evaluation of mushroom (Lentinus edodes) and mealworm (Tenebrio molitor) as dog food attractant

Chicken liver is a main protein source to prepare attractant for dog food. However, animal proteins are costly. Seeking high quality and low-cost protein sources has been a goal for the industry. Mushroom Lentinus edodes (L. edodes) and Mea...

A Prospective, Randomized Trial Comparing Hydromorphone and Nalbuphine for Postcesarean Patient-Controlled Analgesia and Developing a Risk Prediction Model for Inadequate Analgesia

Kaiwen Zhang,1,* Jiaoli Sun,1,* Caixia Zhang,2 Bo Jiao,1 Wencui Zhang,1 Shangchen Yu,1 Xueqin Cao,1 Zhiqiang Zhou,1 Guanglei Zhang,1 Xianwei Zhang1 1Department of Anesthesiology and Pain Medicine,Hubei Key Laboratory of Geri...

The Downregulation of eIF3a Contributes to Vemurafenib Resistance in Melanoma by Activating ERK via PPP2R1B

Vemurafenib, a BRAF V600E inhibitor, provides therapeutic benefits for patients with melanoma, but the frequent emergence of drug resistance remains a challenge. An understanding of the mechanisms underlying vemurafenib resistance may gener...

Robotic-assisted anatomic anterior cruciate ligament reconstruction: a comparative analysis of modified transtibial and anteromedial portal techniques in cadaveric knees

Introduction: This study employed surgical robot to perform anatomic single-bundle reconstruction using the modified transtibial (TT) technique and anteromedial (AM) portal technique. The purpose was to directly compare tunnel and graft cha...

Molecular Informatics, Chemometrics, and Sensory Omics for Constructing an Umami Peptide Cluster Library Across the Entire Lager Beer Brewing Process

Umami taste in lager beer not only determined body fullness and the backbone of aftertaste, but also affected the controllability and interpretability of flavor expression across the entire brewing process. Based on stage-wise sampling, pep...

Corrigendum: New Sesquiterpenoids From Plant-Associated Irpex lacteus

A systematic review of the impact of master's-educated nurses on inpatient care

Aim: Review the impact of master's-educated nurses on inpatient care in different healthcare systems and specialties. Background: Improved healthcare service quality and efficiency are needed due to a number of factors, including an aging p...

Purification, Characterization and Bactericidal Action of Lysozyme, Isolated from <i>Bacillus subtillis</i> BSN314: A Disintegrating Effect of Lysozyme on Gram-Positive and Gram-Negative Bacteria

In the present study, lysozyme was purified by the following multi-step methodology: salt (ammonium sulfate) precipitation, dialysis, and ultrafiltration. The lysozyme potential was measured by enzymatic activity after each purification ste...

Urine metals concentrations and dyslexia among children in China

Background: Exposures to heavy metals has been linked to many developmental disorders. However, few studies have investigated the effects of exposure and co-exposure to metals on dyslexia, especially with regard to dyslexics in China. Objec...

Fenofibrate modified-release pellets with lag phase and high oral bioavailability

Fang Li,1,* Xin Zheng,2,* YongChu Bao,3 Ting Chen,3 Jia Zeng,1 XiaoLi Xu,4 Chao Yan,5 LingLin Feng1 1NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, and Shanghai Engineer...

Full-thickness skin graft versus split-thickness skin graft for radial forearm free flap donor site closure: protocol for a systematic review and meta-analysis

Abstract Background The radial forearm free flap (RFFF) serves as a workhorse for a variety of reconstructions. Although there are a variety of surgical techniques for donor site closure after RFFF raising, the most common techniques are cl...

Mapping Chinese Medical Entities to the Unified Medical Language System

Background. Chinese medical entities have not been organized comprehensively due to the lack of well-developed terminology systems, which poses a challenge to processing Chinese medical texts for fine-grained medical knowledge representatio...

Disrupted Functional Connectivity of Cornu Ammonis Subregions in Amnestic Mild Cognitive Impairment: A Longitudinal Resting-State fMRI Study

Background: The cornu ammonis (CA), as part of the hippocampal formation, represents a primary target region of neural degeneration in amnestic mild cognitive impairment (aMCI). Previous studies have revealed subtle structural deficits of t...

Artificial neural network–based model for sleep quality prediction for frontline medical staff during major medical assistance

Background: The sleep quality of medical staff was severely affected during COVID-19, but the factors influencing the sleep quality of frontline staff involved in medical assistance remained unclear, and screening tools for their sleep qual...

Association between social health status and health-related quality of life among community-dwelling elderly in Zhejiang

Abstract Background Population aging is an inevitable trend and previous studies have showed the relationship between social health related factors and health-related quality of life (HR-QOL) in the elderly. The objective of this study is t...

Deep learning-based multimodal data fusion in bone tumor management: Advances in clinical decision support

Bone tumors (BTs)—including osteosarcoma, Ewing sarcoma, and chondrosarcoma—are rare but biologically complex malignancies characterized by pronounced heterogeneity in anatomical location, histological subtype, and molecular alterations. Re...