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Academic Articles & Research Papers
Showing 20 of 284 academic articles
Sepiso K. Masenga, Fernando Elijovich, Benson M. Hamooya, Selestine Nzala et al. • Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
(2020)
Background People living with HIV (PLWH) are at increased risk of cardiovascular disease, including hypertension, which persists despite effective plasma viral suppression on antiretroviral therapy. HIV infection is characterized by long‐te...
DOAJ
Open Access (DOAJ)
DOI: 10.1161/JAHA.118.011450
William Rodriguez, Ileana M. Cristea • Viruses
(2026)
Persistent oncovirus infections account for 15–20% of the global cancer burden, driving multiple forms of human cancer. To maintain persistent infection and spread, oncoviruses drive alterations in host cell metabolism, immune signaling, an...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/v18030288
Oscar Girón-Vallejo, Bernardo Garcia-Nuñez, Isidoro Narbona-Arias, Alexander Siles-Hinojosa et al. • Children
(2025)
Three-dimensional (3D) modeling and printing technologies are increasingly used in pediatric surgery, offering improved anatomical visualization, surgical planning, and personalized approaches to complex conditions. Compared to standard ima...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/children12091202
Wei Yan, Guo-hui Xiao, Li-juan Wang, Yan Zhou et al. • Journal of Translational Medicine
(2025)
Abstract Background The stiffness of the matrix is closely related to the progression of hepatocellular carcinoma (HCC). Although direct targeting of stromal rigidity in HCC remains a clinical challenge, cancer-associated fibroblasts (CAFs)...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s12967-025-06325-5
T. Malivanova, E. Skoromyslova, N. Mazurenko • EJC Supplements
(2015)
Tumor necrosis factor alpha (TNF) is a multifunctional cytokine, which possesses various biologic functions depending on the type of the cells and the physiological context. TNF is synthesized by immune cells as well as malignant cells. Acc...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.ejcsup.2015.08.063
Kassandra Lopez, Seigmund Wai Tsuen Lai, Edwin De Jesus Lopez Gonzalez, Raúl G. Dávila et al. • Frontiers in Cell and Developmental Biology
(2023)
Extracellular vesicles (EVs) encompass a diverse set of membrane-derived particles released from cells and are found in numerous biological matrices and the extracellular space. Specific classes of EVs include apoptotic bodies, exosomes, an...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fcell.2023.1154576
Margaret Wooddell PhD, MBA, Dong Dai PhD, Feng Lin PhD, Irene Pan MS et al. • Foot & Ankle Orthopaedics
(2024)
Category: Other Introduction/Purpose: Tenosynovial giant cell tumors (TGCT) are neoplastic, inflammatory lesions that arise within the synovium and can be locally aggressive. Patients with TGCT frequently experience pain and joint swelling,...
DOAJ
Open Access (DOAJ)
DOI: 10.1177/2473011424S00422
Lan Chen, Jing-Xin Zhang, Dong-Ge Liu, Hong-Gang Liu • Diagnostics
(2023)
This paper illustrates a rare syndrome of multiple endocrine neoplasia type 2A (MEN2A) in a family of three generations. In our case, the father, son and one daughter developed phaeochromocytoma (PHEO) and medullary thyroid carcinoma (MTC) ...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/diagnostics13050955
Toledo JO, Moraes CF, Souza VC, Tonet-Furioso AC et al. • Clinical Interventions in Aging
(2015)
Juliana O Toledo,1 Clayton F Moraes,2,3 Vinícius C Souza,2 Audrey C Tonet-Furioso,2 Luís CC Afonso,4 Cláudio Córdova,3 Otávio T Nóbrega1,2 1Graduate Program in Health Sciences, 2Graduate Program in...
DOAJ
Open Access (DOAJ)
Shuping Wang, Pengcheng Chen, Xiaozhen Jing, Jinglin Zou et al. • Materials & Design
(2026)
STING agonist-based immunotherapy holds considerable promise for cancer treatment, yet its efficacy against immunologically “cold” tumors such as lung adenocarcinoma (LUAD) remains markedly limited. A major obstacle lies in the highly glyco...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.matdes.2026.117182
Jing Ma, Ruijuan Ma, Xueke Zeng, Liming Zhang et al. • Journal of Experimental & Clinical Cancer Research
(2023)
Abstract Background Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer ...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s13046-023-02768-0
Yujun Cai, Gengjia Chen, Minzhao Lin, Bo Li et al. • Aggregate
(2024)
Abstract Nanodrugs capable of aggregating in the tumor microenvironment (TME) have demonstrated great efficiency in improving the therapeutic outcome. Among various approaches, the strategy utilizing electrostatic interaction as a driving f...
DOAJ
Open Access (DOAJ)
DOI: 10.1002/agt2.476
Xiangyi Kong, Peng Gao, Jing Wang, Yi Fang et al. • Journal of Hematology & Oncology
(2023)
Abstract Early detection and diagnosis of many cancers is very challenging. Late stage detection of a cancer always leads to high mortality rates. It is imperative to develop novel and more sensitive and effective diagnosis and therapeutic ...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s13045-023-01463-z
Evelina Polmickaitė-Smirnova, Jonas Šarlauskas, Kastis Krikštopaitis, Živilė Lukšienė et al. • Applied Sciences
(2020)
The antitumor drug 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ (1)) along with a number of newly synthesized tirapazamine derivatives (TPZs) bearing substitutions at the 3-amine position of TPZ (1) were estimated for their an...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/app10124062
Sepideh Parvizpour, Jafar Razmara, Mohammad M. Pourseif, Yadollah Omidi • BioImpacts
(2019)
Introduction: Triple-negative breast cancer (TNBC) is an important subtype of breast cancer, which occurs in the absence of estrogen, progesterone and HER-2 receptors. According to the recent studies, TNBC may be a cancer testis antigen (CT...
DOAJ
Open Access (DOAJ)
DOI: 10.15171/bi.2019.06
Bin Zhao, Sa Chen, Ye Hong, Liangliang Jia et al. • Pharmaceutics
(2022)
The conventional cancer therapeutic modalities include surgery, chemotherapy and radiotherapy. Although immunotherapy and targeted therapy are also widely used in cancer treatment, chemotherapy remains the cornerstone of tumor treatment. Wi...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/pharmaceutics14071522
Sehui Kim, Yeji Park, Jeonghun Kim, Sohyun Kim et al. • Vaccines
(2023)
Despite numerous studies on cancer treatment, cancer remains a challenging disease to cure, even after decades of research. In recent years, the cancer vaccine has emerged as a promising approach for cancer treatment, offering few unexpecte...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/vaccines11091503
Tommaso A. Salamone, Sofia Marotta, Stella Mrmić, Salvatore Raffa et al. • Cancer Nanotechnology
(2025)
Abstract Background Trastuzumab (TZ) resistance remains a significant challenge in the treatment of human epidermal growth factor receptor 2 (HER2)-positive epithelial ovarian cancer (EOC), necessitating novel therapeutic strategies to impr...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s12645-025-00330-5
Maria B. C. de Matos, Roel Deckers, Benjamin van Elburg, Guillaume Lajoinie et al. • Frontiers in Pharmacology
(2019)
Mistletoe lectin-1 (ML1) is a nature-derived macromolecular cytotoxin that potently induces apoptosis in target cells. Non-specific cytotoxicity to normal cells is one of the major risks in its clinical application, and we therefore propose...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fphar.2019.01463
Joshua eMcCarroll, Joshua eMcCarroll, Joann eTeo, Joann eTeo et al. • Frontiers in Physiology
(2014)
Despite improvements in our understanding of pancreatic cancer and the emerging concept of personalized medicine for the treatment of this disease, it is still the fourth most common cause of cancer death in the western world. It is establi...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fphys.2014.00002