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Improved InSAR Deformation Time Series with Multi-Stable Points Technique for Atmospheric Correction

Baohang Wang, Guangrong Li, Chaoying Zhao, Liye Yang et al. • Geosciences (2026)

Potential tropospheric noise is a critical factor that undermines the effectiveness of deformation monitoring in Synthetic Aperture Radar Interferometry (InSAR) technologies. In most scenarios, many point targets within the InSAR deformatio...

DOAJ Open Access (DOAJ) DOI: 10.3390/geosciences16020059

Adaptation of SIVmac to baboon primary cells results in complete absence of in vivo baboon infectivity

Veronica Obregon-Perko, Amanda Mannino, Jason T. Ladner, Vida Hodara et al. • Frontiers in Cellular and Infection Microbiology (2024)

While simian immunodeficiency virus (SIV) infection is non-pathogenic in naturally infected African nonhuman primate hosts, experimental or accidental infection in rhesus macaques often leads to AIDS. Baboons, widely distributed throughout ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcimb.2024.1408245

Metabolic modeling-based drug repurposing in Glioblastoma

Claudio Tomi-Andrino, Alina Pandele, Klaus Winzer, John King et al. • Scientific Reports (2022)

Abstract The manifestation of intra- and inter-tumor heterogeneity hinders the development of ubiquitous cancer treatments, thus requiring a tailored therapy for each cancer type. Specifically, the reprogramming of cellular metabolism has b...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-022-14721-w

Seaweed-Derived Sulfated Polysaccharides as Potential Agents for Prevention and Treatment of Influenza and COVID-19

N. N. Besednova, T. N. Zvyagintseva, B. G. Andriukov, T. S. Zaporozhets et al. • Антибиотики и Химиотерапия (2021)

The review presents materials describing the seaweed-derived sulfated polysaccharides (SPS) as potential means for prevention and treatment of viral diseases of the respiratory tract, mainly influenza and COVID-19. The literature materials o...

DOAJ Open Access (DOAJ) DOI: 10.37489/0235-2990-2021-66-7-8-50-66

An ML-Based Radial Velocity Estimation Algorithm for Moving Targets in Spaceborne High-Resolution and Wide-Swath SAR Systems

Tingting Jin, Xiaolan Qiu, Donghui Hu, Chibiao Ding • Remote Sensing (2017)

Multichannel synthetic aperture radar (SAR) is a significant breakthrough to the inherent limitation between high-resolution and wide-swath (HRWS) compared with conventional SAR. Moving target indication (MTI) is an important application of...

DOAJ Open Access (DOAJ) DOI: 10.3390/rs9050404

Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges

Kirsten M. Wright, Janis McFerrin, Armando Alcázar Magaña, Armando Alcázar Magaña et al. • Frontiers in Nutrition (2022)

Botanical products are frequently sold as dietary supplements and their use by the public is increasing in popularity. However, scientific evaluation of their medicinal benefits presents unique challenges due to their chemical complexity, i...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnut.2021.799137

Identification of DDIT4 as a potential prognostic marker associated with chemotherapeutic and immunotherapeutic response in triple-negative breast cancer

Xuanzhao Chen, Zeyan Li, Meihua Liang, Ziyang Zhang et al. • World Journal of Surgical Oncology (2023)

Abstract Background Triple-negative breast cancer (TNBC) is the most heterogenous and aggressive subtype of breast cancer. Chemotherapy remains the standard treatment option for patients with TNBC owing to the unavailability of acceptable t...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12957-023-03078-7

Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey.

Audrey Sabbagh, Pierre Darlu, Brigitte Crouau-Roy, Estella S Poloni • PLoS ONE (2011)

Arylamine N-acetyltransferase 2 (NAT2) is involved in human physiological responses to a variety of xenobiotic compounds, including common therapeutic drugs and exogenous chemicals present in the diet and the environment. Many questions rem...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0018507

Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions

Kevin O. Murray, Sophia A. Mahoney, Ravinandan Venkatasubramanian, Douglas R. Seals et al. • Experimental Gerontology (2023)

Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is characterized by impaired vascular endothelial function and stiffeni...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2023.112105

Effective analysis of neurotoxicity and mechanisms of dioctyl terephthalate using network toxicology

Hao Tang, Ting Qin, Zhiwen Yan, Changqing Li et al. • Frontiers in Neuroscience (2026)

ObjectiveDioctyl terephthalate (DOTP), a widely used plasticizer in food packaging and environmental materials, has raised concerns regarding its potential impact on human health. This study aims to investigate the neurotoxicity-related mec...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2026.1783807

Lipofuscin: Wear Pigment or Alarm Signal for Cardiac AlloGraft Vasculopathy?

Anca Otilia Farcas, Mihai Ciprian Stoica, Septimiu Voidazan, Carmen Corina Radu et al. • Diagnostics (2026)

Background: CAV (cardiac allograft vasculopathy) is considered the leading cause of late post-transplant mortality and affects approximately 50% of transplant patients at 10 years post-transplant. Its etiopathogenetic mechanism is considere...

DOAJ Open Access (DOAJ) DOI: 10.3390/diagnostics16152432

UPLC-MS/MS Metabolomics Reveals Babao Dan’s Mechanisms in MASH Treatment with Integrating Network Pharmacology and Molecular Docking

Shijiao Zhang, Yanding Su, Ao Han, He Qi et al. • Pharmaceuticals (2025)

Background: Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive disease that easily develops into cirrhosis and hepatocellular carcinoma, but its pathogenesis is not clear, and most therapeutic drugs have obvious limita...

DOAJ Open Access (DOAJ) DOI: 10.3390/ph18081111

VirtualToxLab™ - In silico prediction of the toxic (endocrine-disrupting) potential of drugs, chemicals and natural products. Two years and 2,000 compounds of experience: a progress report

Angelo Vedani, Martin Smiesko, Morena Spreafico, Ourania Peristera et al. • ALTEX: Alternatives to Animal Experimentation (2009)

The VirtualToxLab™ is an in silico tool for predicting the toxic (endocrine-disrupting) potential of drugs, chemicals and natural products. It is based on a fully automated protocol and calculates the binding affinity of any molecule of int...

DOAJ Open Access (DOAJ) DOI: 10.14573/altex.2009.3.167

Development and validation of a portable, point-of-care canine distemper virus qPCR test.

Ania Tomaszewicz Brown, Denise McAloose, Paul P Calle, Angelika Auer et al. • PLoS ONE (2020)

Canine distemper virus (CDV) is a multi-host pathogen that can cause significant mortality in domestic, wild terrestrial and marine mammals. It is a major conservation threat in some endangered species. Infection can result in severe respir...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0232044

Neurotoxicity of PM<sub>2.5</sub>-Bound Multi-Pollutant Mixtures in Parkinson’s Disease: Exploring the <i>INPP5D</i>/SHIP1-PI3K-AKT Axis via an Integrative Multi-Omics Study

Lufei Chen, Chaoxian Dai, Zhenfang Wu, Yuhan Lin et al. • Journal of Xenobiotics (2026)

Accumulating epidemiological evidence links ambient PM2.5 exposure to elevated Parkinson’s disease (PD) risk, yet the neurotoxicity triggered by PM2.5 multi-pollutant mixtures under real co-exposure scenarios remains insufficiently elucidat...

DOAJ Open Access (DOAJ) DOI: 10.3390/jox16060184

Effects on Dopaminergic Neurons Are Secondary in COX-Deficient Locomotor Dysfunction in Drosophila

Cagri Yalgin, Bohdana Rovenko, Ana Andjelković, Margot Neefjes et al. • iScience (2020)

Summary: Dopaminergic (DA) neurons have been implicated as key targets in neurological disorders, notably those involving locomotor impairment, and are considered to be highly vulnerable to mitochondrial dysfunction, a common feature of suc...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.isci.2020.101362

A noncanonical AR addiction drives enzalutamide resistance in prostate cancer

Yundong He, Ting Wei, Zhenqing Ye, Jacob J. Orme et al. • Nature Communications (2021)

Resistance to second generation anti-androgen therapies such as enzalutamide (ENZ) can emerge in prostate cancer patients. Here, the authors identify an ENZ-resistant mechanism driven by AR-dependent transcription of noncanonical targets th...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-021-21860-7

A real-world clinical validation for AI-based MRI monitoring in multiple sclerosis

Michael Barnett, Dongang Wang, Heidi Beadnall, Antje Bischof et al. • npj Digital Medicine (2023)

Abstract Modern management of MS targets No Evidence of Disease Activity (NEDA): no clinical relapses, no magnetic resonance imaging (MRI) disease activity and no disability worsening. While MRI is the principal tool available to neurologis...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41746-023-00940-6