Academic Articles & Research Papers

Early disc degeneration in radiotherapy-treated childhood brain tumor survivors

Abstract Background Childhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity. This study aimed to investigate lumbar disc degenerat...

Genital Warts in Women Vaccinated against HPV in Childhood: A Systematic Review

Human papillomavirus (HPV) is the most prevalent sexually transmitted infection among young women. Notably, more than ten years after the introduction of HPV vaccination programs in Europe, it is essential to review the real-world evidence ...

MUT-7 Provides Molecular Insight into the Werner Syndrome Exonuclease

Werner syndrome (WS) is a rare recessive genetic disease characterized by premature aging. Individuals with this disorder develop normally during childhood, but their physiological conditions exacerbate the aging process in late adolescence...

Editorial Summer 2025

Early childhood education (ECE) lays the foundation for a child's lifelong learning journey. More and more, new insights and understandings of child development are evolving, and concomitantly, new preschool education has seen several excit...

Artificial intelligence-driven anthropometric assessment for young children: evaluating the accuracy and practicality of a digital image-based length and weight prediction tool

Background Monitoring early childhood growth is vital, as growth faltering could indicate nutritional or health issues requiring prompt intervention. Our study’s aim was to assess the performance of a length-weight artificial intelligence (...

Dataset on perception of public college students on underage drinking in Nigeria

Alcohol is the most widely used substance of abuse among youths in Nigeria. Underage drinking poses a serious public health problem in most colleges and despite the health and safety risk, consumption of alcohol is rising. Having recourse t...

Contributions of childhood abuse and neglect to reward neural substrates in adolescence

Background: Childhood adverse experiences may come to bear particularly during adolescence, when neural reward systems are developing rapidly and psychopathology spikes. Despite prior work differentiating threat- (abuse) vs. deprivation- (n...

Predictors of community acquired childhood pneumonia among 2–59 months old children in the Amhara Region, Ethiopia

Abstract Background Worldwide, pneumonia is the third leading cause of death in under 5 years children. Ethiopia is ranked 4th out of 15 countries having the highest burdens of the death rate among under-five children due to pneumonia. Rega...

Conceptualisation and design of a protocol for a novel social drivers and primary care screening tool in paediatric orthopaedics: a quality improvement initiative

Introduction Paediatric patients with elevated healthcare needs have limited access to care, contributing to insufficient preventive services. Social drivers of health (SDOH), such as inadequate nutrition and poor community support, contrib...

Association of maternal metabolic risk factors with offspring body mass index (BMI) trajectories in early childhood: a retrospective cohort study

Objective This study aimed to identify body mass index (BMI) growth trajectories from birth to 24 months of age and examine the independent and additive effects of four maternal metabolic risk factors, namely prepregnancy BMI, the rate of g...

Effectiveness of an electronic clinical decision support system in improving the management of childhood illness in primary care in rural Nigeria: an observational study

Objectives To evaluate the impact of ALgorithm for the MANAgement of CHildhood illness (‘ALMANACH’), a digital clinical decision support system (CDSS) based on the Integrated Management of Childhood Illness, on health and quality of care ou...

Early childhood household instability, adolescent structural neural network architecture, and young adulthood depression: A 21-year longitudinal study

Unstable and unpredictable environments are linked to risk for psychopathology, but the underlying neural mechanisms that explain how instability relate to subsequent mental health concerns remain unclear. In particular, few studies have fo...

Molecular Characterization of Cryptosporidium Species in Children with Diarrhea in North West of Iran

Cryptosporidium is one of the most common causes of childhood diarrhea in developing countries. The aim of this randomized pilot study was to detect and characterize infective species and determine the genotypes of Cryptosporidium parasites...

Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia

Abstract Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, espec...

Monitoring development from 0–6 years: an online system, standardized for Dutch children

BackgroundMonitoring and screening children's development from infancy into early childhood is important for prevention purposes, as potential delay may best be addressed as soon as possible. For an efficient monitoring system, standardized...

Beginning at the ends: telomeres and human disease [version 1; referees: 4 approved]

Studies of rare and common illnesses have led to remarkable progress in the understanding of the role of telomeres (nucleoprotein complexes at chromosome ends essential for chromosomal integrity) in human disease. Telomere biology disorders...

Identification of confounders and estimating the causal effect of place of birth on age-specific childhood vaccination

Abstract Background In causal analyses, some third factor may distort the relationship between the exposure and the outcome variables under study, which gives spurious results. In this case, treatment groups and control groups that receive ...

Incarcerated youth with history of childhood trauma are characterized by altered neural activation during a Go/NoGo fMRI task.

Genetic and Psychosocial Risk Factors Associated with Suicide Among Community Veterans: Implications for Screening, Treatment and Precision Medicine

Joseph A Boscarino,1 Richard E Adams,2 Thomas G Urosevich,3 Stuart N Hoffman,4 H Lester Kirchner,1 Xin Chu,5 Weixing Shi,5 Joseph J Boscarino,6 Ryan J Dugan,1 Carrie A Withey,1 Charles R Figley7 1Department Population Health Sciences, Geisi...

Current Trends in Tolerance Induction in Cow's Milk Allergy: From Passive to Proactive Strategies

This review addresses the current strategies of inducing tolerance development in infant and childhood cow's milk protein allergy (CMPA). The change in prevention strategies for CMPA has been emphasized based on the lack of evidence to supp...