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Showing 20 of 197 academic articles

Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults

Yan Zhao, Tingting Chen, Conghua Ji, Yuxin Shang et al. • Experimental Gerontology (2026)

Background: Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2025.113010

Neuronal-Derived EV Biomarkers Track Cognitive Decline in Alzheimer’s Disease

Erden Eren, Jeannie-Marie Leoutsakos, Juan Troncoso, Constantine G. Lyketsos et al. • Cells (2022)

The hallmarks of Alzheimer’s disease (AD) pathology are senile plaques containing amyloid-beta (Aβ) and neurofibrillary tangles containing hyperphosphorylated tau. Additional pathologies often co-exist, whereas multiple pathogenic mechanism...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells11030436

Comparative Study of Field-Effect Transistors Based on Graphene Oxide and CVD Graphene in Highly Sensitive NT-proBNP Aptasensors

Anastasiia Kudriavtseva, Stefan Jarić, Nikita Nekrasov, Alexey V. Orlov et al. • Biosensors (2024)

Graphene-based materials are actively being investigated as sensing elements for the detection of different analytes. Both graphene grown by chemical vapor deposition (CVD) and graphene oxide (GO) produced by the modified Hummers’ method ar...

DOAJ Open Access (DOAJ) DOI: 10.3390/bios14050215

Abundance and Distribution of GDGTs in Incubated Artificial Soils with No Fossil Pool

Rui MIAO, Zenghao ZHAO, Zeyuan CAI, Xu LIU et al. • Yankuang ceshi (2025)

Glycerol dialkyl glycerol tetraethers (GDGTs) derived from microorganisms are important tools for the study of paleoclimate changes. Incubation experiments are helpful to clarify the mechanisms for the responses of GDGTs to environmental pa...

DOAJ Open Access (DOAJ) DOI: 10.15898/j.ykcs.202405240120

MiRNA Profiles in Lymphoblastoid Cell Lines of Finnish Prostate Cancer Families.

Daniel Fischer, Tiina Wahlfors, Henna Mattila, Hannu Oja et al. • PLoS ONE (2015)

BACKGROUND:Heritable factors are evidently involved in prostate cancer (PrCa) carcinogenesis, but currently, genetic markers are not routinely used in screening or diagnostics of the disease. More precise information is needed for making tr...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0127427

ITRI Biofilm Prevented Thoracic Adhesion in Pigs That Received Myocardial Ischemic Induction Treated by Myocardial Implantation of EPCs and ECSW Treatment

Jiunn-Jye Sheu, Jui-Ning Yeh, Pei-Hsun Sung, John Y. Chiang et al. • Cell Transplantation (2024)

This study tested the hypothesis that ITRI Biofilm prevents adhesion of the chest cavity. Combined extracorporeal shock wave (ECSW) + bone marrow-derived autologous endothelial progenitor cell (EPC) therapy was superior to monotherapy for i...

DOAJ Open Access (DOAJ) DOI: 10.1177/09636897241253144

Time-in-range and hypoglycemia in cognitive health of older adults with Type 2 diabetes: An emerging evidence synthesis

Dharmendra Kumar Gupta, Arunima Chaudhuri • Muller Journal of Medical Sciences and Research (2026)

Type 2 diabetes mellitus (T2DM) is a recognized risk factor for cognitive decline and dementia, but the mechanisms linking glycemic dysregulation to brain health remain incompletely understood. Glycated hemoglobin captures long-term average...

DOAJ Open Access (DOAJ) DOI: 10.4103/mjmsr.mjmsr_83_25

Effect of probiotics on cognitive function and cardiovascular risk factors in mild cognitive impairment and Alzheimer’s disease: an umbrella meta-analysis

Bin Xiao, Lina Fu, Zhe Yang, Guran Yu • Journal of Health, Population and Nutrition (2025)

Abstract Background This umbrella meta-analysis evaluates the effects of probiotics on cognitive function and metabolic health in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) by synthesizing findings from meta-analyses of ra...

DOAJ Open Access (DOAJ) DOI: 10.1186/s41043-025-00816-3

Stress Levels Escalate When Repeatedly Performing Tasks Involving Threats

Johan Bertilsson, Johan Bertilsson, Diederick C. Niehorster, Diederick C. Niehorster et al. • Frontiers in Psychology (2019)

Police work may include performing repeated tasks under the influence of psychological stress, which can affect perceptual, cognitive and motor performance. However, it is largely unknown how repeatedly performing stressful tasks physically...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpsyg.2019.01562

Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways

Elliya Park, Lily Yi Li, Chunsheng He, Azhar Z. Abbasi et al. • Advanced Science (2023)

Abstract Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new strategy, using multitargeted bi...

DOAJ Open Access (DOAJ) DOI: 10.1002/advs.202207238

FAM83A as a Potential Biological Marker Is Regulated by miR-206 to Promote Cervical Cancer Progression Through PI3K/AKT/mTOR Pathway

Li Rong, Haiyu Li, Zhaodong Li, Jing Ouyang et al. • Frontiers in Medicine (2020)

Background and Objective: Chemotherapy and radiotherapy are effective treatment options for cervical cancer (CC), but their efficacy is limited by short survival rate of about 5 years particularly for advance stage CC. Bioinformatics analys...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2020.608441

Identification of functional pathways for regenerative bioactivity of selected renal cells

Wei Sha, Timothy Bertram, Deepak Jain, Cory Brouwer et al. • Stem Cell Research & Therapy (2022)

Abstract Background Selected renal cells (SRC) are in Phase II clinical trials as a kidney-sourced, autologous, tubular epithelial cell-enriched cell-based therapy for chronic kidney disease (CKD). In preclinical studies with rodent models ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13287-022-02713-6

Multi-Cohort Transcriptomics Combined with Mendelian Randomization Identifies PPARGC1A, NAAA and GIPC2 as NLRP3 Inflammasome-Related Key Genes in Ulcerative Colitis

Cheng J, Huang Y • Journal of Inflammation Research (2026)

Jian Cheng, Yangfeng Huang Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, School of Medicine,University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of ChinaCorrespond...

DOAJ Open Access (DOAJ)

Ethical and social implications of approaching death prediction in humans - when the biology of ageing meets existential issues

Marie Gaille, Marco Araneda, Clément Dubost, Clémence Guillermain et al. • BMC Medical Ethics (2020)

Abstract Background The discovery of biomarkers of ageing has led to the development of predictors of impending natural death and has paved the way for personalised estimation of the risk of death in the general population. This study inten...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12910-020-00502-5

Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types

Sipeng Shen, Ruyang Zhang, Yue Jiang, Yi Li et al. • Molecular Cancer (2021)

Abstract N6-Methyladenosine (m6A) is an RNA modification that interacts with numerous coding and non-coding RNAs and plays important roles in the development of cancers. Nonetheless, the clinical impacts of m6A interactive genes on these ca...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12943-021-01362-2

Metabolomic sweet spot clock predicts mortality and age-related diseases in the Canadian Longitudinal Study on Aging

Olga Vishnyakova, Joosung Min, Stephen Leach, Xiaowei Song et al. • Communications Medicine (2026)

Abstract Background Chronological age does not capture individual health or resilience. Advances in metabolomics have enabled development of molecular aging biomarkers that capture deviations between biological and chronological age, highli...

DOAJ Open Access (DOAJ) DOI: 10.1038/s43856-026-01375-2

Circulating tumour cell enumeration, biomarker analyses, and kinetics in patients with colorectal cancer and other GI malignancies

Walla Malkawi, Areeb Lutfi, Maaz Khan Afghan, Lamisha Mashiyat Shah et al. • Frontiers in Oncology (2023)

ObjectiveMost of the work in terms of liquid biopsies in patients with solid tumors is focused on circulating tumor DNA (ctDNA). Our aim was to evaluate the feasibility of using circulating tumor cells (CTCs) in peripheral blood samples fro...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2023.1305181

HIV incidence among sexual health clinic attendees in England: First estimates for black African heterosexuals using a biomarker, 2009-2013.

Adamma Aghaizu, Jennifer Tosswill, Daniela De Angelis, Helen Ward et al. • PLoS ONE (2018)

IntroductionThe HIV epidemic in England is largely concentrated among heterosexuals who are predominately black African and men who have sex with men (MSM). We present for the first time trends in annual HIV incidence for adults attending s...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0197939