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Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS

Xinyi Wei, Yanding Su, Qian Cheng, Songmao Liang et al. • Frontiers in Pharmacology (2024)

Objective: A remarkably sensitive, accurate, and efficient ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach was developed as a facile and expeditious method for measuring cilofexor concentration in beag...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2024.1334402

The Effect of Yinchenhao Decoction on the Pharmacokinetic Profile of Futibatinib by HPLC-MS/MS

Chunfu Wang, Songmao Liang, Jiachen Xu, Yingfan Zhai et al. • Separations (2024)

Futibatinib is an excellent fibroblast growth factor receptor 1–4 (FGFR 1–4) inhibitor that exhibits selective anti-tumor activeness against FGFR-deregulated tumors. A new high-performance liquid chromatography-tandem mass spectrometry (HPL...

DOAJ Open Access (DOAJ) DOI: 10.3390/separations11070213

Case report: Incidentally discovered case of pheochromocytoma as a cause of long COVID-19 syndrome

Christian G. Ziegler, Carina Riediger, Matthias Gruber, Carola Kunath et al. • Frontiers in Endocrinology (2022)

Pheochromocytomas (PCCs) are rare but potentially lethal tumors that arise from the adrenal medulla. The clinical suspicion and diagnosis of PCC can be challenging due to the non-specific nature of signs and symptoms. In many patients, infe...

DOAJ Open Access (DOAJ) DOI: 10.3389/fendo.2022.967995

Anti-inflammatory activity of two varieties of pumpkin seed oil in an adjuvant arthritis model in rats

S. Y. Al-Okbi, D. A. Mohamed, E. Kandil, M. A. Abo-Zeid et al. • Grasas y Aceites (2017)

The aim of the present research was to evaluate the anti-inflammatory activity of pumpkin seed oils (PSOs) of an Egyptian and European variety, in a rat model of adjuvant arthritis. Edema thickness, plasma tumor necrosis factor-α (TNF-α) an...

DOAJ Open Access (DOAJ) DOI: 10.3989/gya.0796161

Protocol to measure human IL-6 secretion from CAR T cell-primed macrophage and monocyte lineage cells in vitro and in vivo using humanized mice

Thao Nguyen, Toshiaki Yoshikawa, Yusuke Ito, Hitomi Kasuya et al. • STAR Protocols (2024)

Summary: Chimeric antigen receptor (CAR) T cell therapy often causes serious toxicities, such as cytokine release syndrome (CRS), mainly due to interleukin-6 (IL-6) secreted by monocyte lineage cells. Here, we describe a protocol to generat...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.xpro.2024.103423

Essential requirement of complex number for oscillatory phenomenon in intracellular trafficking process

Yoshinori Marunaka, M.D., Ph.D., Katsumi Yagi, Ph.D. • Computational and Structural Biotechnology Journal (2021)

Intracellular protein trafficking processes consisting of three intracellular states are described by three differential equations. To solve the equations, a quadratic equation is required, and its roots are generally real or complex. The p...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.csbj.2021.04.053

Treatment of Gluteal Tendinopathy: A Systematic Review and Stage-Adjusted Treatment Recommendation

Andreas Ladurner MD, Jane Fitzpatrick PhD, MBBS, John M. O’Donnell MBBS • Orthopaedic Journal of Sports Medicine (2021)

Background: Gluteal tendinopathy is the most common lower limb tendinopathy. It presents with varying severity but may cause debilitating lateral hip pain. Purpose: To review the therapeutic options for different stages of gluteal tendinopa...

DOAJ Open Access (DOAJ) DOI: 10.1177/23259671211016850

Association between maternal plasma glucose levels during pregnancy and risk of preterm birth: a retrospective study

Na Wang, Bingqi Han, Sumiao Hong, Xinrui Shi et al. • BMC Pregnancy and Childbirth (2025)

Abstract Background Preterm birth is a leading cause of health problems and death in infants. This study aims to investigate the association between maternal plasma glucose levels during pregnancy and risk of preterm birth. Methods This pop...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12884-025-08309-1

A Single Simulated Heliox Dive Modifies Endothelial Function in the Vascular Wall of ApoE Knockout Male Rats More Than Females

Simin Berenji Ardestani, Simin Berenji Ardestani, Vladimir V. Matchkov, Ingrid Eftedal et al. • Frontiers in Physiology (2019)

IntroductionThe number of divers is rising every year, including an increasing number of aging persons with impaired endothelial function and concomitant atherosclerosis. While diving is an independent modulator of endothelial function, lit...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphys.2019.01342

Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers

Cayetano Javier Carrión-García, Eduardo Jesús Guerra-Hernández, Belén García-Villanova, Mauro Serafini et al. • Antioxidants (2020)

(1) Background: Little is known about the interlinkages between dietary and plasma non-enzymatic antioxidant capacity (D-NEAC and P-NEAC, respectively) and the body’s antioxidant and inflammation response. Our aim was to explore these assoc...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox9040301

Innovative polymer-based electrochemical platform for detecting ESAT-6 in human blood for pulmonary tuberculosis diagnosis

Xiu-An Ye, Shu-Hong Lin, Liang-Yu Chen, Jie-Ren Li et al. • Sensing and Bio-Sensing Research (2025)

Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), necessitates early diagnosis for effective patient care. Despite advancements in TB diagnostics, there remains an urgent need to discover innovative non-sputum-based m...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.sbsr.2025.100816

Depressive phenotype shapes behavioral, neuroendocrine and molecular responses to repetitive transcranial magnetic stimulation in preclinical models of depression

Marta Boffa, Marta Boffa, Sara Spalletti, Sara Spalletti et al. • Frontiers in Molecular Neuroscience (2026)

IntroductionRepetitive transcranial magnetic stimulation (rTMS) is an established non-invasive treatment for treatment-resistant depression (TRD), yet its neurobiological mechanisms remain only partially understood. We investigated whether ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnmol.2026.1939025

Surface Modified Activated Carbons: Sustainable Bio-Based Materials for Environmental Remediation

Manoj Kumar Jha, Sahira Joshi, Ram Kumar Sharma, Allison A Kim et al. • Nanomaterials (2021)

Global warming and water/air contamination caused by human activities are major challenges in environmental pollution and climate change. The improper discharge of a large amount of agro-forest byproduct is accelerating these issues mainly ...

DOAJ Open Access (DOAJ) DOI: 10.3390/nano11113140

Impact of Fasting Plasma Glucose on Electrolyte Imbalance, Lipid Profile, and Associated Health Complications in Type 1 and Type 2 Diabetic Patients: A Cross‐Sectional Study in Rural Bangladesh

Md Mosahaq Ali, Koushik Ahmed, Md Yeakub Ali, Md Fazle Rabbi et al. • Health Science Reports (2026)

ABSTRACT Background and Aims Diabetes mellitus is a pervasive chronic disorder disrupting electrolyte homeostasis and lipid metabolism, thereby predisposing patients to severe complications. This study investigates the associations between ...

DOAJ Open Access (DOAJ) DOI: 10.1002/hsr2.71822

SIRT1 and miR-34a as Potential Plasma Biomarkers in the Acute Phase of Ischemic Stroke

Mitra Ansari, Moslem Esmati, Seyed khalil Rashidi, Shahram Rafie et al. • International Journal of Molecular and Cellular Medicine (2025)

Stroke is the major cause of disability and mortality worldwide. Identification of molecular biomarkers in the early hours after stroke is important in terms of both diagnostic and therapeutic applications. miR-34a, a highly expressed miRNA...

DOAJ Open Access (DOAJ)

Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog

Kyung Ho Park, Tae‐Un Kim, Hyun‐Woo Park, Seoung‐Woo Lee et al. • Veterinary Medicine and Science (2023)

Abstract Background Most extramedullary plasmacytomas (EMPs) aresolitary and located in the head and neck region. They may also occur in the visceral parts of the body. Objectives Here, we report a case of oral EMP followed by neoplastic pl...

DOAJ Open Access (DOAJ) DOI: 10.1002/vms3.1086

Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy

Wei Liu, Yan Xu, Yi Wang, Lugui Qiu et al. • Journal for ImmunoTherapy of Cancer (2024)

Background Over 50% of patients with relapsed or refractory large B-cell lymphoma (r/r LBCL) receiving CD19-targeted chimeric antigen receptor (CAR19) T-cell therapy fail to achieve durable remission. Early identification of relapse or prog...

DOAJ Open Access (DOAJ) DOI: 10.1136/jitc-2023-008450