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Lipofuscin: Wear Pigment or Alarm Signal for Cardiac AlloGraft Vasculopathy?

Anca Otilia Farcas, Mihai Ciprian Stoica, Septimiu Voidazan, Carmen Corina Radu et al. • Diagnostics (2026)

Background: CAV (cardiac allograft vasculopathy) is considered the leading cause of late post-transplant mortality and affects approximately 50% of transplant patients at 10 years post-transplant. Its etiopathogenetic mechanism is considere...

DOAJ Open Access (DOAJ) DOI: 10.3390/diagnostics16152432

UPLC-MS/MS Metabolomics Reveals Babao Dan’s Mechanisms in MASH Treatment with Integrating Network Pharmacology and Molecular Docking

Shijiao Zhang, Yanding Su, Ao Han, He Qi et al. • Pharmaceuticals (2025)

Background: Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive disease that easily develops into cirrhosis and hepatocellular carcinoma, but its pathogenesis is not clear, and most therapeutic drugs have obvious limita...

DOAJ Open Access (DOAJ) DOI: 10.3390/ph18081111

The features analysis of hemoglobin expression on visual information transmission pathway in early stage of Alzheimer’s disease

Xuehui Li, Pan Tang, Xinping Pang, Xianghu Song et al. • Scientific Reports (2024)

Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized primarily by cognitive impairment. The motivation of this paper is to explore the impact of the visual information transmission pathway (V–H pathway) on AD, and...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-024-64099-0

Building evidences in Public Health Emergency Preparedness (“BePHEP” Project)—a systematic review

Michelangelo Mercogliano, Gloria Spatari, Chiara Noviello, Francesca Di Serafino et al. • International Journal for Equity in Health (2025)

Abstract Introduction Humanitarian crises exacerbate the vulnerability of already fragile healthcare systems and significantly increase the risk of infectious disease outbreaks in low- and middle-income countries (LMICs). This systematic re...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12939-025-02382-w

Hospitalisations for physical abuse in infants and children less than 5 years, 2013‒2021: a multinational cohort study using administrative data from five European countries

Catherine Quantin, Jonathan Cottenet, Colleen Chambers, Natasha Kennedy et al. • International Journal of Population Data Science (2025)

Objectives Child physical abuse (CPA) is a global public health problem associated with lifelong negative consequences, yet reliable epidemiologic data are lacking. We did a multinational cohort study to analyse trends in CPA hospitalisatio...

DOAJ Open Access (DOAJ) DOI: 10.23889/ijpds.v10i3.3028

Case report: Incidentally discovered case of pheochromocytoma as a cause of long COVID-19 syndrome

Christian G. Ziegler, Carina Riediger, Matthias Gruber, Carola Kunath et al. • Frontiers in Endocrinology (2022)

Pheochromocytomas (PCCs) are rare but potentially lethal tumors that arise from the adrenal medulla. The clinical suspicion and diagnosis of PCC can be challenging due to the non-specific nature of signs and symptoms. In many patients, infe...

DOAJ Open Access (DOAJ) DOI: 10.3389/fendo.2022.967995

Diet in 1-year-old farm and control children and allergy development: results from the FARMFLORA birth cohort

Karin Jonsson, My Green, Malin Barman, Agneta Sjöberg et al. • Food & Nutrition Research (2016)

Background: A farming environment confers strong protection against allergy development. We have previously shown that farming mothers consume more full-fat dairy than control mothers, who instead consume more low-fat dairy, margarine, and ...

DOAJ Open Access (DOAJ) DOI: 10.3402/fnr.v60.32721

TRACK-CF prospective cohort study: Understanding early cystic fibrosis lung disease

Eva Steinke, Eva Steinke, Eva Steinke, Olaf Sommerburg et al. • Frontiers in Medicine (2023)

BackgroundLung disease as major cause for morbidity in patients with cystic fibrosis (CF) starts early in life. Its large phenotypic heterogeneity is partially explained by the genotype but other contributing factors are not well delineated...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2022.1034290

What motivates SARS-CoV-2 vaccine trial participants? A pre- and post-participation survey study

Olivia A. C. Lamers, Meta Roestenberg, Martine C. de Vries, Marie-Astrid Hoogerwerf • Trials (2024)

Abstract Background Scientific advancement, including the testing and licensing of new drugs, relies heavily on clinical trials with healthy individuals. The motivations of clinical trial participants have been discussed intensively, as som...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13063-024-08582-z

DNA polymorphisms in inflammatory and endocrine signals linked to frailty are also associated with obesity: data from the FRASNET cohort

Sarah Damanti, Sarah Damanti, Lorena Citterio, Laura Zagato et al. • Frontiers in Endocrinology (2024)

BackgroundObesity and frailty are prevalent geriatric conditions that share some pathophysiological mechanisms and are associated with adverse clinical outcomes. The relationship between frailty, obesity, and polymorphism remains inadequate...

DOAJ Open Access (DOAJ) DOI: 10.3389/fendo.2024.1412160

Clinical features of the course of Hirschsprung’s disease in newborns and infants with consideration of the extent of colonic aganglionosis

V.P. Prytula, O.O. Kurtash, V.F. Rybalchenko, S.F. Hussaini • Український журнал Перинатологія і педіатрія (2024)

The clinical course of Hirschsprung’s disease (HD) in newborns and infants depends on the extent of сolonic aganglionosis, the age of patient, the presence of associated malformations and complications. The aim - to study the peculiariti...

DOAJ Open Access (DOAJ) DOI: 10.15574/PP.2024.97.55

Evaluation of clinical quality improvement interventions: feasibility of an integrated approach

Sandeep Reddy, Kevin Mc Namara, Mary Malakellis, Tim Denton et al. • Pilot and Feasibility Studies (2019)

Abstract Background Cardiovascular diseases (CVD) are the largest cause of death and disability in Australia. Australian national guidelines for the primary prevention of CVD recommend that all adults without CVD and aged 45 years or more a...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40814-018-0386-1

Lipid profile in elderly and centenarian subjects in Kazakhstan: a case-control study

Yu. Ganzhula, Zh. Borykbay, V. Tkachev, S. Urazova et al. • Central Asian Journal of Medical Hypotheses and Ethics (2024)

Introduction. The health of centenarians is a major focus in global studies. Dyslipidemia is directly linked to the risk of cardiovascular diseases, which pose a growing burden on healthcare due to the increasing elderly population. Studyin...

DOAJ Open Access (DOAJ) DOI: 10.47316/cajmhe.2024.5.3.04

NLRP3 Inflammasome-Mediated Pyroptosis Pathway Contributes to the Pathogenesis of Candida albicans Keratitis

Huifang Lian, Huifang Lian, Huifang Lian, Huifang Lian et al. • Frontiers in Medicine (2022)

PurposeFungal keratitis is a sight-threatening corneal infection caused by fungal pathogens, and the pathogenic mechanisms have not been fully elucidated. The aim of this study was to determine whether NOD-like receptor family pyrin domain ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2022.845129

On mathematical modeling of fractional-order stochastic for tuberculosis transmission dynamics

C.W. Chukwu, E. Bonyah, M.L. Juga, Fatmawati • Results in Control and Optimization (2023)

Tuberculosis remains one of the most dangerous diseases globally and has affected many people in Sub-Saharan Africa. In this paper, a fractional stochastic model of tuberculosis disease was formulated and analyzed. The existence and uniquen...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.rico.2023.100238

A Fractional-Order Complexity Framework for Misinformation Propagation With Fact-Checking Saturation and Social Vulnerability Dynamics

Shewafera Wondimagegnhu Teklu, M. A. Abdelkawy, Waleed Adel • Complexity (2026)

Misinformation spreads through communities in ways that resemble infectious diseases, but existing mathematical models often miss three real-world complexities: People remember past information (memory effects), some folks are more easily f...

DOAJ Open Access (DOAJ) DOI: 10.1155/cplx/8861194