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Involvement of two uptake mechanisms of gold and iron oxide nanoparticles in a co-exposure scenario using mouse macrophages

Dimitri Vanhecke, Dagmar A. Kuhn, Dorleta Jimenez de Aberasturi, Sandor Balog et al. • Beilstein Journal of Nanotechnology (2017)

Little is known about the simultaneous uptake of different engineered nanoparticle types, as it can be expected in our daily life. In order to test such co-exposure effects, murine macrophages (J774A.1 cell line) were incubated with gold (A...

DOAJ Open Access (DOAJ) DOI: 10.3762/bjnano.8.239

Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex

Sai Shashank Chavali, Steven Z. Chou, Wenxiang Cao, Thomas D. Pollard et al. • Nature Communications (2024)

Abstract Arp2/3 complex nucleates branched actin filaments for cell and organelle movements. Here we report a 2.7 Å resolution cryo-EM structure of the mature branch junction formed by S. pombe Arp2/3 complex that provides details about int...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-024-46179-x

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson’s Disease: Comparative Analysis of G2019S and I1371V Variants

Khushboo Singh, Roon Banerjee, Chandrakanta Potdar, Anisha Shaw et al. • Cells (2026)

Mutations in leucine-rich repeat kinase 2 (LRRK2) are among the most common genetic causes of Parkinson’s disease (PD), yet substantial heterogeneity exists among pathogenic variants. How mutations in distinct functional domains of LRRK2 di...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells15040342

Dielectric Properties of Phosphatidylcholine Membranes and the Effect of Sugars

Victoria Vitkova, Vesela Yordanova, Galya Staneva, Ognyan Petkov et al. • Membranes (2021)

Simple carbohydrates are associated with the enhanced risk of cardiovascular disease and adverse changes in lipoproteins in the organism. Conversely, sugars are known to exert a stabilizing effect on biological membranes, and this effect is...

DOAJ Open Access (DOAJ) DOI: 10.3390/membranes11110847

<i>Vegfr3</i> and <i>Tbx1</i> Interact in Cardiac Morphogenesis

Stefania Martucciello, Marchesa Bilio, Sara Cioffi, Ilaria Aurigemma et al. • Journal of Cardiovascular Development and Disease (2026)

Gene inactivation in model organisms has identified numerous genes and signaling pathways involved in mammalian cardiac outflow tract (OFT) development. Human genetics data have implicated the VEGFR3 gene in OFT development, but when and wh...

DOAJ Open Access (DOAJ) DOI: 10.3390/jcdd13080399

Pairwise Performance Comparison of Docking Scoring Functions: Computational Approach Using InterCriteria Analysis

Maria Angelova, Petko Alov, Ivanka Tsakovska, Dessislava Jereva et al. • Molecules (2025)

Scoring functions are key elements in docking protocols as they approximate the binding affinity of a ligand (usually a small bioactive molecule) by calculating its interaction energy with a biomacromolecule (usually a protein). In this stu...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules30132777

Comparative Analysis of Tools and Approaches for Source Tracking Listeria monocytogenes in a Food Facility Using Whole-Genome Sequence Data

Balamurugan Jagadeesan, Leen Baert, Martin Wiedmann, Renato H. Orsi • Frontiers in Microbiology (2019)

As WGS is increasingly used by food industry to characterize pathogen isolates, users are challenged by the variety of analysis approaches available, ranging from methods that require extensive bioinformatics expertise to commercial softwar...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2019.00947

Dysregulation of Angiogenesis and Inflammatory Genes in Endometrial Mesenchymal Stem Cells and Their Contribution to Endometriosis

Shermineh Heydari, Ladan Kashani, Mehrdad Noruzinia • Iranian Journal of Allergy, Asthma and Immunology (2021)

Endometriosis is a common, chronic, inflammatory disorder in women, characterized by the presence of endometrial tissue outside the uterus cavity. The disease affects ~10% of women during their reproductive age. There is some debates on the...

DOAJ Open Access (DOAJ)

Atorvastatin suppresses high-risk colorectal adenomas via reprogramming of lipid metabolism and Inhibition of stemness

Wentong Chen, Mengxiao Ge, Shuangyi Sun, Hanxiao Zhang et al. • Scientific Reports (2025)

Abstract As critical precursors to colorectal cancer (CRC), high-risk colorectal adenomas (HR-CRAs) lack effective chemopreventive strategies beyond endoscopic resection. We previously established a standardized protocol for culturing patie...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-32406-y

Computational analyses on delineating specificity of 2-hydroxy-3,5-dinitrobenzamide, a BH3-mimetic, towards anti-apoptotic proteins

Dakshinamurthy Sivakumar, Natarajan Hari, Thirunavukkarasu Sivaraman • Bangladesh Journal of Pharmacology (2014)

We have herein computationally examined binding affinities and specificity of 2-hydroxy-3,5-dinitrobenzamide (HDNB), a small chemical molecular BH3-mimetic identified by means of ‘peptidodynmimetic method’, on the BH3-binding grooves of six...

DOAJ Open Access (DOAJ)

Spray dried inulin–sodium carboxymethylcellulose microcarriers with solid-to-colloidal transition: Development for foliar delivery of polyphenol-rich extract

Rita Patrizia Aquino, Teresa Mencherini, Pierluigi Mazzei, Tiziana Esposito et al. • Carbohydrate Polymer Technologies and Applications (2025)

This study reports on the development of a carbohydrate-based spray-dried microparticulate system (F-CHES) conceived for the stabilization and foliar delivery of polyphenol-rich plant extracts for sustainable phyto defense applications. Che...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.carpta.2025.101023

Sex-based estimation of biological variation in plasma-free amino acid concentrations among healthy adults

Müjgan Ercan, Emiş Deniz Akbulut, Ayşen Caniklioğlu, Esra Fırat Oğuz et al. • Journal of Mass Spectrometry and Advances in the Clinical Lab (2025)

Introduction: Free amino acid (FAA) analysis plays a crucial role in diagnosing and monitoring inborn errors of metabolism, assessing nutritional status, and identifying metabolic imbalances associated with various diseases. This study aime...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jmsacl.2025.04.010

OCCURENCE OF OESTRUS OVIS IN GOATS IN PALAKKAD, KERALA AND ITS SUCCESSFUL MANAGEMENT

Bindu Lakshmanan, K.T. Rajimon, K.M. Manjusha, P. Muhammed Shiyas et al. • Journal of Veterinary and Animal Sciences (2019)

Oestrus ovis is a larviparous protelean fly whose larvae parasitize the nasal cavities and adjoining sinuses of sheep and goats. It is primarily a widespread infestation of sheep and rarely occurs in goat, camel, deer, reindeer, elk and ib...

DOAJ Open Access (DOAJ)

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia

Temesgen GB, Menon M, Gizaw ST, Yimenu BW et al. • International Journal of General Medicine (2022)

Gelagey Baye Temesgen,1 Menakath Menon,2 Solomon Tebeje Gizaw,2 Bayu Wondimneh Yimenu,1 Melaku Mekonen Agidew3 1Department of Biomedical Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Medical Biochemistry School o...

DOAJ Open Access (DOAJ)

Synthesis of 9-arylalkynyl- and 9-aryl-substituted benzo[b]quinolizinium derivatives by Palladium-mediated cross-coupling reactions

Siva Sankar Murthy Bandaru, Darinka Dzubiel, Heiko Ihmels, Mohebodin Karbasiyoun et al. • Beilstein Journal of Organic Chemistry (2018)

9-Arylbenzo[b]quinolizinium derivatives were prepared with base-free Suzuki–Miyaura coupling reactions between benzo[b]quinolizinium-9-trifluoroborate and selected benzenediazonium salts. In addition, the Sonogashira coupling reaction betwe...

DOAJ Open Access (DOAJ) DOI: 10.3762/bjoc.14.161

Pengaruh pembiayaan bagi hasil, non Performing Financing (NPF) dan Biaya Operasional Pendapatan Operasional (BOPO) terhadap Return On Assets (ROA) pada bank umum syariah

Nur Kholis, Lintang Kurniawati • Jurnal Ekonomi dan Keuangan Islam (2018)

This study aims to analyse the effect of profit-sharing financing, Non-Performing Financing (NPF) and Operating Expense Ratio (OER) both simultaneously and partially on ROA (Return On Assets) of Islamic banks in Indonesia. Sampling techniqu...

DOAJ Open Access (DOAJ) DOI: 10.20885/jeki.vol4.iss2.art3