Academic Articles & Research Papers

Piezo1 knockdown activates PI3K/AKT and enhances SPP1 to drive M2 macrophage polarization and reduce cardiac inflammation

Abstract Piezo1 plays a key role in the immune response during sepsis. To date, our understanding of the role of Piezo1 in inflammatory diseases has mostly been limited to influencing vasomotor function and regulating inflammatory infiltrat...

Co-Regulation of Protein Coding Genes by Transcription Factor and Long Non-Coding RNA in SARS-CoV-2 Infected Cells: An In Silico Analysis

Altered expression of protein coding gene (PCG) and long non-coding RNA (lncRNA) have been identified in SARS-CoV-2 infected cells and tissues from COVID-19 patients. The functional role and mechanism (s) of transcriptional regulation of de...

Efficacious role of silica nanoparticles in improving growth and yield of wheat under drought stress through stress-gene upregulation

Climate change is now evident and severe water shortage due to unpredictable raining season along with extended summers is expected to hamper crop production across the globe. Application of nanoparticle based formulations is one of the mos...

Metabolomic Profile Alterations Associated with the SLC16A11 Risk Haplotype Following a Lifestyle Intervention in People With Prediabetes

Background: A risk haplotype in SLC16A11 characterized by alterations in fatty acid metabolism emerged as a genetic risk factor associated with increased susceptibility to type 2 diabetes (T2D) in Mexican population. Its role on treatment r...

Establishment of Biocontrol Agents and Their Impact on Rhizosphere Microbiome and Induced Grapevine Defenses Are Highly Soil-Dependent

With a reduction in available chemical treatments, there is an increased interest in biological control of grapevine trunk diseases. Few studies have investigated the impact of introducing beneficial microorganisms in the rhizosphere on the...

Meta-analysis of MitraClip and PASCAL for transcatheter mitral edge-to-edge repair

Abstract Background Despite the promising results of both MitraClip and PASCAL systems for the treatment of mitral regurgitation (MR), there is limited data on the comparison of both systems regarding their safety and efficacy. We aim to co...

Causal analysis between altered levels of interleukins and obstructive sleep apnea

BackgroundInflammation proteins including interleukins (ILs) have been reported to be related to obstructive sleep apnea (OSA). The aims of this study were to estimate the levels for several key interleukins in OSA and the causal effects be...

Current Trends in Tolerance Induction in Cow's Milk Allergy: From Passive to Proactive Strategies

This review addresses the current strategies of inducing tolerance development in infant and childhood cow's milk protein allergy (CMPA). The change in prevention strategies for CMPA has been emphasized based on the lack of evidence to supp...

Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target

During tumor development and progression, intrinsic and extrinsic factors trigger endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the increased expression of molecular chaperones to cope with the stress and...

Bio-Engineered Graphene-Based Cage for Efficient Local Enrichment and Biodegradation of Aqueous Organic Wastes

Abstract Microorganism immobilization has attracted great attention as a traditional method to overcome aqueous organic wastes containing N, N-dimethylformamide (DMF). In this approach, graphene oxide was modified with functional polymer fi...

Comparison of Therapeutic Effects of Electroacupuncture Treatment of Insomnia at Different Time

Objective To compare the therapeutic effects of evening-electroacupuncture(EA) and morning-EA for insomnia.Methods Sixty cases of simple insomnia patients were randomly divided into evening-EA group and morning-EA group,with 30 cases in eac...

Factors predicting active treatment free-survival and initial experience with mpMRI as a selection tool in patient undergoing active surveillance: 10-year follow-up of SIUrO PRIAS-ITA working group

A Novel Depression Rehabilitation Game Framework Using VR Based on Neurofeedback

At present,depression is treated with antidepressant drugs and assisted with psychotherapy and physical therapy,and these expensive and time-consuming treatment methods often end prematurely and result in a prolonged course without effectiv...

Research Frontiers in the Field of Agricultural Resources and the Environment

From the perspective of project and paper datasets, research frontier recognition in the field of agricultural resources and the environment using the Latent Dirichlet Allocation (LDA) topic extraction model was studied. By combining the wi...

Critical Cybersecurity Scenarios in Drinking Water Treatment Plants

The increasing interconnectivity with external networks and the higher reliance on digital systems make chemical and process industries, including waste and drinking water treatment plants, more vulnerable to cyber-attacks. Historical evide...

Understanding patient perspectives on digital therapeutics and its platform for insomnia: insights from focused group interviews

Abstract Background Digital therapeutics (DTx) is a treatment option that uses computer software to provide evidence-based interventions for medical disorders. DTx platforms are digital services that facilitate interactions among stakeholde...

A Multi-Stage NLP Framework for Knowledge Discovery from Crop Disease Research Literature

Extracting and organizing knowledge from the agricultural crop disease research literature are challenging tasks because of the heterogeneous terminologies, complicated symptom descriptions, and unstructured nature of scientific documents. ...

Natural Language Processing Techniques for Text Classification of Biomedical Documents: A Systematic Review

The classification of biomedical literature is engaged in a number of critical issues that physicians are expected to answer. In many cases, these issues are extremely difficult. This can be conducted for jobs such as diagnosis and treatmen...

Multi-omics profiling identifies a putative Akkermansia–HK3–lactate immunometabolic link associated with JPZS treatment in lupus nephritis.

A pretreatment ECM-high/immune-low transcriptomic score is associated with pathological complete response after neoadjuvant therapy in breast cancer.