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Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress

Hwa-Young Lee, Seung-Wook Kim, Geum-Hwa Lee, Min-Kyung Choi et al. • Scientific Reports (2017)

Abstract For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effec...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-017-06872-y

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

Kevin Achberger, Christopher Probst, Jasmin Haderspeck, Sylvia Bolz et al. • eLife (2019)

The devastating effects and incurable nature of hereditary and sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa urgently require the development of new therapeutic strategies. Add...

DOAJ Open Access (DOAJ) DOI: 10.7554/eLife.46188

Implications of Isoprostanes and Matrix Metalloproteinase-7 Having Potential Role in the Development of Colorectal Cancer in Males

Mahmood Rasool, Arif Malik, Ahmad Ashar Ghuman, Muhammad Abdul Basit Ashraf et al. • Frontiers in Oncology (2018)

BackgroundColorectal cancer (CRC) is the third most common type of cancer and leading cause of death worldwide. Major risk factors involved in the development of CRC are increased dietary sources, genetics, and increasing age. Purpose of th...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2018.00205

Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis

Rui Xiong, Boxin Geng, Wenyang Jiang, Yong Hu et al. • Clinical Epigenetics (2023)

Abstract Background Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary fibrosis (PF). Histone deacetylase 3 (HDAC3) is an important enzyme that regulates protein stabil...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13148-023-01588-5

Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy

Wei Liu, Yan Xu, Yi Wang, Lugui Qiu et al. • Journal for ImmunoTherapy of Cancer (2024)

Background Over 50% of patients with relapsed or refractory large B-cell lymphoma (r/r LBCL) receiving CD19-targeted chimeric antigen receptor (CAR19) T-cell therapy fail to achieve durable remission. Early identification of relapse or prog...

DOAJ Open Access (DOAJ) DOI: 10.1136/jitc-2023-008450

Effect of Glycyrrhiza uralensis crude water extract on the expression of Nitric Oxide Synthase 2 gene during myogenesis

Afsha Fatima Qadri, Sibhghatulla Shaikh, Ye Chan Hwang, Khurshid Ahmad et al. • Heliyon (2024)

Glycyrrhiza uralensis is a traditional herbal medicine with significant bioactivity. This study investigated the effect of G. uralensis crude water extract (GU-CWE) on nitric oxide synthase 2 (NOS2) expression during myogenesis. GU-CWE trea...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2024.e34747

PRODUCTION OF L-TRYPTOPHAN BY MUTANTS OF CORYNEBACTERIUM GLUTAMICUM

Hamies Mohamed, Ghada El Nady, A. Ali, A. Abdel-Razik et al. • Arab Universities Journal of Agricultural Sciences (2018)

L-Tryptophan, is one of the amino acids, also is one of the 9 essential amino acids of human which cannot be synthesized internally by him, microbial production is the main method for obtaining tryptophan for commercial uses. Typical microo...

DOAJ Open Access (DOAJ) DOI: 10.21608/ajs.2018.28383