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Clinical Features and Pathogenesis of Noma: A Narrative Review Highlighting the Emerging Strategies for Prevention and Management

Bhagyesh Sapkale, Sonali Choudhari • Journal of Clinical and Diagnostic Research (2026)

Noma, also known as cancrum oris, is a rapidly progressive gangrenous infection that affects the oral and facial tissues of malnourished children in impoverished regions, particularly in sub-Saharan Africa. The disease typically begins as a...

DOAJ Open Access (DOAJ) DOI: 10.7860/JCDR/2026/82789.22726

Big data in healthcare: management, analysis and future prospects

Sabyasachi Dash, Sushil Kumar Shakyawar, Mohit Sharma, Sandeep Kaushik • Journal Of Big Data (2019)

‘Big data’ is massive amounts of information that can work wonders. It has become a topic of special interest for the past two decades because of a great potential that is hidden in it. Various public and private sector industries generate,...

OPENALEX cc-by DOI: https://doi.org/10.1186/s40537-019-0217-0

Mortality trends among hospitalised COVID-19 patients in Sweden: A nationwide observational cohort study

Kristoffer Strålin, Erik Wahlström, Sten Walther, Anna M Bennet-Bark et al. • The Lancet Regional Health. Europe (2021)

Background: It is important to know if mortality among hospitalised COVID-19 patients has changed as the pandemic has progressed. The aim of this study was to describe the dynamics over time of mortality among patients hospitalised for COVI...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.lanepe.2021.100054

Correlation of Social Network Attributes with Individuals’ Score on Bipolar Spectrum Diagnostic Scale

Amir Momeni Boroujeni, Nima Khalighinejad, Elham Yousefi, Elham Asadi • Basic and Clinical Neuroscience (2012)

Introduction: Bipolar Spectrum Disorders include a variety of mood disorders from bipolar II disorder to conditions characterized by hyperthymic mood states. It has been suggested that psychosocial factors also play an important role in bip...

DOAJ Open Access (DOAJ)

Alterations in white matter fiber density associated with structural MRI and metabolic PET lesions following multimodal therapy in glioma patients

Michel Friedrich, Ezequiel Farrher, Svenja Caspers, Svenja Caspers et al. • Frontiers in Oncology (2022)

BackgroundIn glioma patients, multimodality therapy and recurrent tumor can lead to structural brain tissue damage characterized by pathologic findings in MR and PET imaging. However, little is known about the impact of different types of d...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2022.998069

Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning

Sijie Li, Sijie Li, Changhong Ren, Changhong Ren et al. • Frontiers in Genetics (2020)

Hypoxic/ischemic preconditioning (HPC/IPC) is an innate neuroprotective mechanism in which a number of endogenous molecules are known to be involved. Tuberous sclerosis complex 1 (TSC1), also known as hamartin, is thought to be one such mol...

DOAJ Open Access (DOAJ) DOI: 10.3389/fgene.2020.582368

Friends with Social Benefits: Host-Microbe Interactions as a Driver of Brain Evolution and Development?

Roman M Stilling, Roman M Stilling, Seth R Bordenstein, Timothy G Dinan et al. • Frontiers in Cellular and Infection Microbiology (2014)

The tight association of the human body with trillions of colonizing microbes that we observe today is the result of a long evolutionary history. Only very recently have we started to understand how this symbiosis also affects brain functio...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcimb.2014.00147

Liposomal Neostigmine Bromide: A Localized Therapeutic Approach for Detrusor Underactivity

Kunpeng Liu, Haitao Gong, Binbin Jiao, Zhenshan Ding et al. • Advanced NanoBiomed Research (2024)

This study aims to evaluate the therapeutic potential of cationic liposomal neostigmine bromide (NB), a novel drug delivery system, for the treatment of detrusor underactivity. By comparing the characteristics of NB‐liposomes (NLP), NB‐β‐cy...

DOAJ Open Access (DOAJ) DOI: 10.1002/anbr.202300109

Storage Properties of Double-Layer Films Enriched with <i>Phytolacca americana</i> L. Extract as Active Packaging for African Catfish, with a New Approach to Antioxidant Film Assay and Additional Analysis of <i>P. americana</i> Extract Toxicity on Human Cell Lines

Joanna Maria Jasińska, Klaudia Michalska, Joanna Tkaczewska, Katarzyna Tkacz et al. • Molecules (2025)

Novel double-layer films based on furcellaran (FUR) and gelatin (GEL) with the addition of Phytolacca americana L. (PA) extract were used as active packaging for African catfish fillets. Films with PA extract have been shown to minimize the...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules30071447

Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma

Zelin Tian, Chen Xu, Peijun Yang, Zhibin Lin et al. • Frontiers in Immunology (2022)

Hepatocellular carcinoma(HCC) is the sixth most common cancer in the world and is usually caused by viral hepatitis (HBV and HCV), alcoholic, and non-alcoholic fatty liver disease(NAFLD). Viral hepatitis accounts for 80% of HCC cases worldw...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2022.984728

Persistent Endothelial Dysfunction in Post-Acute COVID-19 Syndrome: A Case-Control Study

Pasquale Ambrosino, Ilenia Calcaterra, Antonio Molino, Pasquale Moretta et al. • Biomedicines (2021)

Background: Endothelial dysfunction has a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its disabling complications. We designed a case-control study to assess the alterations of endothelium-dependent flow-mediated...

DOAJ Open Access (DOAJ) DOI: 10.3390/biomedicines9080957

Computational Tools; Indispensable Armamentarium of Medical Biotechnology

Nutan, Swapnil Jain, K Shilpa, Akanksha Tomar et al. • Indian Journal of Science and Technology (2016)

Objective: Computational infrastructure of medical biotechnology provides insight into elements of genomics, proteomics for understanding diseases and biological systems in a more comprehensive and systematic way. The present study exclusiv...

OPENALEX cc-by DOI: https://doi.org/10.17485/ijst/2016/v9i32/100745

Convergent Adaptation in the Dominant Global Hospital Clone ST239 of Methicillin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>

Sarah L. Baines, Kathryn E. Holt, Mark B. Schultz, Torsten Seemann et al. • mBio (2015)

ABSTRACT Infections caused by highly successful clones of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) are a major public health burden. The globally dominant sequence type 239 (ST239) HA-MRSA clone has persiste...

DOAJ Open Access (DOAJ) DOI: 10.1128/mBio.00080-15

CD36‐Binding Amphiphilic Nanoparticles for Attenuation of α‐Synuclein‐Induced Microglial Activation

Nanxia Zhao, Nicola L. Francis, Shuang Song, Vladyslav Kholodovych et al. • Advanced NanoBiomed Research (2022)

Neuroinflammation is one of the hallmarks contributing to Parkinson's disease (PD) pathology, where microglial activation occurs as one of the earliest events, triggered by extracellular α‐synuclein (aSYN) binding to the cluster of differen...

DOAJ Open Access (DOAJ) DOI: 10.1002/anbr.202100120

Peptide-functionalized periodic mesoporous silica nanoparticles for monocyte-specific TET3 Silencing enhance cardiac repair after acute myocardial infarction

Hao Jin, Jiandong Ding, Xiaoguo Zhang, Shouquan Cheng et al. • Journal of Nanobiotechnology (2025)

Abstract Modulating the balance between pro- and anti-inflammatory monocyte subsets holds therapeutic promise in acute myocardial infarction (AMI); however, effective and selective strategies are still lacking. In this study, we are the fir...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03782-4

Optimally biosynthesized, PEGylated gold nanoparticles functionalized with quercetin and camptothecin enhance potential anti-inflammatory, anti-cancer and anti-angiogenic activities

Priyadarshani S. Sadalage, Reshma V. Patil, Darshana V. Havaldar, Shruti S. Gavade et al. • Journal of Nanobiotechnology (2021)

Abstract Background The development of nano delivery systems is rapidly emerging area of nanotechnology applications where nanomaterials (NMs) are employed to deliver therapeutic agents to specific site in a controlled manner. To accomplish...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-021-00836-1

Bioremediation of Persistent Organic Pollutant—Oxybenzone with <i>Pleurotus djamor</i>

Agata Kryczyk-Poprawa, Wojciech Baran, Katarzyna Sułkowska-Ziaja, Katarzyna Kała et al. • Applied Sciences (2025)

Oxybenzone, a common sunscreen ingredient, has been widely detected in various environmental matrices, posing significant ecological and health risks. The present study demonstrates, for the first time, the capacity of Pleurotus djamor to d...

DOAJ Open Access (DOAJ) DOI: 10.3390/app15094707