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Analysis of taxonomic distinctness and priority conservation areas as a basis for heritage enhancement of floristic diversity: the case of the ‘hotspot’ of the islands of Numidia (North-eastern Algeria)

Tarek Hamel, Noelia Hidalgo Triana, Amel Meddad-Hamza, Amir Boulemtafes et al. • Mediterranean Botany (2022)

The identification of priority conservation areas (PCA) plays an important role in biodiversity conservation, but uncertainties create challenges for conservation planning. The objective was to test a method based on 'taxonomic distinctness...

DOAJ Open Access (DOAJ) DOI: 10.5209/mbot.81125

Biosynthesis of rare 20(R)-protopanaxadiol/protopanaxatriol type ginsenosides through Escherichia coli engineered with uridine diphosphate glycosyltransferase genes

Lu Yu, Yuan Chen, Jie Shi, Rufeng Wang et al. • Journal of Ginseng Research (2019)

Background: Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jgr.2017.09.005

Biodiversidade e considerações biogeográficas das Cyanobacteria de uma área de Manguezal do Estado de Pernambuco, Brasil

Branco Luis Henrique Zanini, Moura Ariadne do Nascimento, Silva Adriana Cristina da, Bittencourt-Oliveira Maria do Carmo • Acta Botânica Brasílica (2003)

Manguezais caracterizam-se por apresentarem amplas variações ambientais (principalmente de salinidade, irradiância e teor de oxigênio) e possuírem substrato relativamente instável, o que exige adaptações específicas dos organismos para habi...

DOAJ Open Access (DOAJ)

Functional MRI of Handwriting Tasks: A Study of Healthy Young Adults Interacting with a Novel Touch-Sensitive Tablet

Mahta Karimpoor, Nathan W. Churchill, Fred Tam, Corinne E. Fischer et al. • Frontiers in Human Neuroscience (2018)

Handwriting is a complex human activity that engages a blend of cognitive and visual motor skills. Current understanding of the neural correlates of handwriting has largely come from lesion studies of patients with impaired handwriting. Tas...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnhum.2018.00030

Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts

Camila Fabiani, Camila Fabiani, Silvia S. Antollini, Silvia S. Antollini • Frontiers in Cellular Neuroscience (2019)

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with satu...

DOAJ Open Access (DOAJ) DOI: 10.3389/fncel.2019.00309

Mechanistic insights into TAM-mediated OMP assembly in Gram-negative bacteria

Qinghua Luo, Xintan Dong, Zhaxi Zerang, Yujiao Chen et al. • Cell Reports (2026)

Summary: The β-barrel assembly machinery (BAM) is essential for outer membrane protein (OMP) biogenesis in Gram-negative bacteria and represents a validated target for antibiotic development. Its evolutionary relative, the translocation and...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.celrep.2026.117733

Pairwise Performance Comparison of Docking Scoring Functions: Computational Approach Using InterCriteria Analysis

Maria Angelova, Petko Alov, Ivanka Tsakovska, Dessislava Jereva et al. • Molecules (2025)

Scoring functions are key elements in docking protocols as they approximate the binding affinity of a ligand (usually a small bioactive molecule) by calculating its interaction energy with a biomacromolecule (usually a protein). In this stu...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules30132777

An integrated analysis of multiple datasets reveals novel gene signatures in human granulosa cells

Xhulio Dhori, Silvia Gioiosa, Stefania Gonfloni • Scientific Data (2024)

Abstract Granulosa cells (GCs) play crucial roles in oocyte maturation. Through gap junctions and extracellular vesicles, they mediate the exchange of molecules such as microRNAs and messenger RNAs. Different ovarian cell types exhibit uniq...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41597-024-03715-0

Effects of Luteolin on Human Breast Cancer Using Gene Expression Array: Inferring Novel Genes

Shih-Ho Wang, Chin-Hu Wu, Chin-Chuan Tsai, Tai-Yu Chen et al. • Current Issues in Molecular Biology (2022)

Taraxacum officinale (dandelion) is often used in traditional Chinese medicine for the treatment of cancer; however, the downstream regulatory genes and signaling pathways mediating its effects on breast cancer remain unclear. The present s...

DOAJ Open Access (DOAJ) DOI: 10.3390/cimb44050142

Dysregulation of Angiogenesis and Inflammatory Genes in Endometrial Mesenchymal Stem Cells and Their Contribution to Endometriosis

Shermineh Heydari, Ladan Kashani, Mehrdad Noruzinia • Iranian Journal of Allergy, Asthma and Immunology (2021)

Endometriosis is a common, chronic, inflammatory disorder in women, characterized by the presence of endometrial tissue outside the uterus cavity. The disease affects ~10% of women during their reproductive age. There is some debates on the...

DOAJ Open Access (DOAJ)

Correcting palindromes in long reads after whole-genome amplification

Sven Warris, Elio Schijlen, Henri van de Geest, Rahulsimham Vegesna et al. • BMC Genomics (2018)

Abstract Background Next-generation sequencing requires sufficient DNA to be available. If limited, whole-genome amplification is applied to generate additional amounts of DNA. Such amplification often results in many chimeric DNA fragments...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12864-018-5164-1

miR-130a-3p Exacerbates Sepsis-Induced Cardiac Dysfunction by Promoting Inflammation and Targeting PDK4

Jinyu Liu, Xiaowei Yuan, Wei Chen, Dongqin Shen • Clinical and Applied Thrombosis/Hemostasis (2026)

Background Sepsis is frequently complicated by systemic inflammatory injury and cardiac dysfunction, which serve as risk factors of adverse clinical outcomes and increased mortality risk. To clarify the function of miR-130a-3p in sepsis dia...

DOAJ Open Access (DOAJ) DOI: 10.1177/10760296261468449

Constraining PERMANOVA and LDM to within-set comparisons by projection improves the efficiency of analyses of matched sets of microbiome data

Zhengyi Zhu, Glen A. Satten, Caroline Mitchell, Yi-Juan Hu • Microbiome (2021)

Abstract Background Matched-set data arise frequently in microbiome studies. For example, we may collect pre- and post-treatment samples from a set of individuals, or use important confounding variables to match data from case participants ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40168-021-01034-9

CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia

Weiwei Liu, Yan Wang, Zhimei Qiu, Ranzun Zhao et al. • PeerJ (2020)

Background The occurrence of pathological cardiac fibrosis is attributed to tissue hypoxia. Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are involved in the regulation of physiological and pathophy...

DOAJ Open Access (DOAJ) DOI: 10.7717/peerj.9796

OCCURENCE OF OESTRUS OVIS IN GOATS IN PALAKKAD, KERALA AND ITS SUCCESSFUL MANAGEMENT

Bindu Lakshmanan, K.T. Rajimon, K.M. Manjusha, P. Muhammed Shiyas et al. • Journal of Veterinary and Animal Sciences (2019)

Oestrus ovis is a larviparous protelean fly whose larvae parasitize the nasal cavities and adjoining sinuses of sheep and goats. It is primarily a widespread infestation of sheep and rarely occurs in goat, camel, deer, reindeer, elk and ib...

DOAJ Open Access (DOAJ)

GROSS ANATOMICAL STUDIES ON THE CRANIUM OF BARRED JUNGLE OWLET (Glaucidium radiatum malabaricum)

K. B. Sumena, N. S. Sunilkumar, K. M. Lucy, S. Maya et al. • Journal of Veterinary and Animal Sciences (2019)

Present study was conducted with the aim to understand the morphological features of skull of barred jungle owlet.The head of the owletwascollected from the specimen brought for post-mortem, processed and morphological studies were conduct...

DOAJ Open Access (DOAJ)

Functional Assessment of the Quality of Human Hepatocyte Preparations for Cell Transplantation

María Teresa Donato, Agustín Lahoz, Sandra Montero, Ana Bonora et al. • Cell Transplantation (2008)

Hepatocyte transplantation is an alternative therapy to orthotopic liver transplantation for the treatment of liver diseases. Good quality freshly isolated or cryopreserved human hepatocytes are needed for clinical transplantation. However,...

DOAJ Open Access (DOAJ) DOI: 10.3727/096368908787236620

Measuring bank efficiency: DEA application

Jelena Titko, Jelena Stankevičienė, Nataļja Lāce • Technological and Economic Development of Economy (2014)

The paper aims to improve the methodology of measuring efficiency of Latvian banks. Efficiency scores were calculated with application of non-parametric frontier technique Data Envelopment Analysis (DEA). Input-oriented DEA model under Vari...

DOAJ Open Access (DOAJ) DOI: 10.3846/20294913.2014.984255