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Efficacy, safety, and quality of life 4 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A in the phase 3 GENEr8-1 trial

Andrew D. Leavitt, Johnny Mahlangu, Priyanka Raheja, Emily Symington et al. • Research and Practice in Thrombosis and Haemostasis (2024)

Background: Valoctocogene roxaparvovec, an adeno-associated virus-mediated gene therapy for severe hemophilia A, enables endogenous factor (F)VIII expression and provides bleed protection. Objectives: Determine valoctocogene roxaparvovec du...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.rpth.2024.102615

The Association of Parent-Child Communication With Internet Addiction in Left-Behind Children in China: A Cross-Sectional Study

Jingjing Cai, Yun Wang, Feng Wang, Jingjing Lu et al. • International Journal of Public Health (2021)

Objective: Internet addiction has emerged as a growing concern worldwide. This study aimed to compare the prevalence of Internet addiction between left-behind children (LBC) and non-left-behind children (non-LBC), and explore the role of pa...

DOAJ Open Access (DOAJ) DOI: 10.3389/ijph.2021.630700

Molecular Dynamics and In Vitro Studies Elucidating the Tunable Features of Reconfigurable Nanodiscs for Guiding the Optimal Design of Curcumin Formulation

Yongxiao Li, Wanting Xu, Xinpei Wang, Ruizhi Lai et al. • Bioengineering (2024)

In this study, we advance our exploration of Apolipoprotein A-I (apoA-I) peptide analogs (APAs) for their application in nanodisc (ND) assembly, focusing on the dynamic conformational characteristics and the potential for drug delivery. We ...

DOAJ Open Access (DOAJ) DOI: 10.3390/bioengineering11030245

Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress

Haruka Furuta, Mari Yamada, Takuya Nagashima, Shuichi Matsuda et al. • Frontiers in Pharmacology (2023)

Tendinopathy, a degenerative disease, is characterized by pain, loss of tendon strength, or rupture. Previous studies have identified multiple risk factors for tendinopathy, including aging and fluoroquinolone use; however, its therapeutic ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2023.1137952

Lactobacillus brevis 23017 Relieves Mercury Toxicity in the Colon by Modulation of Oxidative Stress and Inflammation Through the Interplay of MAPK and NF-κB Signaling Cascades

Xinpeng Jiang, Shanshan Gu, Di Liu, Lili Zhao et al. • Frontiers in Microbiology (2018)

Aims:Lactobacillus strains have protective effects against heavy metals while relieving oxidative stress and modulating the immune response. Mechanisms that ameliorate heavy metal toxicity and the relationship between probiotics and gut bar...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2018.02425

Effect of Overexpression of the Brain-Specific Na+/Ca2+ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells

Yuki Ota, Takuya Kawanai, Ryo Watanabe, Akira Nishimura et al. • Journal of Pharmacological Sciences (2013)

Abstract.: Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicit...

DOAJ Open Access (DOAJ) DOI: 10.1254/jphs.13012SC

Surface-Modified Nanocellulose for Application in Biomedical Engineering and Nanomedicine: A Review

Tortorella S, Vetri Buratti V, Maturi M, Sambri L et al. • International Journal of Nanomedicine (2020)

Silvia Tortorella, Veronica Vetri Buratti, Mirko Maturi, Letizia Sambri, Mauro Comes Franchini, Erica Locatelli Department of Industrial Chemistry “Toso Montanari”, Alma Mater Studiorum – University of Bologna, Bologna 401...

DOAJ Open Access (DOAJ)

Impact of prolonged obstructive sleep apnea syndrome disease course on retinal-choroidal microcirculation: a WF-SS-OCTA study

Chaomin Chen, Xinyi Chen, Lixia Qin, Mingming Zhao et al. • Photodiagnosis and Photodynamic Therapy (2026)

Purpose: This study used wide-field swept-source optical coherence tomography angiography (WF-SS-OCTA) to evaluate changes in macular vascular density in patients with obstructive sleep apnea syndrome (OSAS) at different stages of disease d...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.pdpdt.2026.105582

Swept source intraoperative OCT angiography

Ziyi Zhang, Tiepei Zhu, Tongtong Cao, Zhaoyu Gong et al. • Journal of Innovative Optical Health Sciences (2021)

To accurately guide surgical instruments during ophthalmic procedures, some necessary intraoperative depth perception is required, which standard surgical microscopes supply limitedly. Intraoperative optical coherence tomography (iOCT), com...

DOAJ Open Access (DOAJ) DOI: 10.1142/S1793545821400095

Non-invasive large-scale imaging of concurrent neuronal, astrocytic, and hemodynamic activity with hybrid multiplexed fluorescence and magnetic resonance imaging (HyFMRI)

Zhenyue Chen, Yi Chen, Irmak Gezginer, Qingxiang Ding et al. • Light: Science & Applications (2025)

Abstract A critical gap currently exists in systematic understanding and experimental validation of the role of astrocytes in neurovascular coupling and their functional links with other brain cells. Despite a broad selection of functional ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41377-025-02003-9

From mid-infrared luminescence to laser gain in chalcogenide glasses and glass-ceramics

Yuhang Zhao, Chenyue Xiao, Xiaosong Lu, Zhiyong Yang • Journal of Advanced Dielectrics (2026)

Mid-infrared (MIR) lasers operating in the 2–6[Formula: see text][Formula: see text]m region are important for spectroscopy, sensing, communications, medicine, lidar, and electro-optical applications. Chalcogenide glasses and glass–ceramics...

DOAJ Open Access (DOAJ) DOI: 10.1142/S2010135X26400102

Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo

Lei Li, Anton A. Shemetov, Mikhail Baloban, Peng Hu et al. • Nature Communications (2018)

Bacterial phytochrome-based probes improved sensitivity in photoacoustic computed tomography. Here the authors engineer a small near-infrared switchable photochromic probe that allows multi-contrast imaging at depths and can be adapted to s...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-018-05231-3

Effect of Phacoemulsification on Macular Thickness and Volume in Diabetic Patients without Retinopathy

Zahra Ameri Golestan, Nasrin Moghadas Sharif, Nasser Shoeibi, Asieh Ehsaei et al. • Reviews in Clinical Medicine (2020)

Introduction: This study aimed to investigate the effect of phacoemulsification on macular thickness and volume in diabetic patients without retinopathy using optical coherence tomography (OCT).Methods: This prospective study included 37 di...

DOAJ Open Access (DOAJ) DOI: 10.22038/rcm.2020.47370.1312

159 Community Engagement (CE) Brokers: Diversity and the Science of CE

Patricia Piechowski, Gina Claxton, Nicola Spencer, Elizabeth Vasile et al. • Journal of Clinical and Translational Science (2022)

OBJECTIVES/GOALS: Since 2013, managers of community engagement (CE) programs across the Clinical and Translational Science Award (CTSA) consortium funded by the National Center for Advancing Translational Sciences (NCATS) have convened mont...

DOAJ Open Access (DOAJ) DOI: 10.1017/cts.2022.67

An elderly low-grade fibromyxoid sarcoma patient with early postoperative recurrences and metastases: a case report and literature review

Xiaoyue Zhang, Yongkang Qiu, Jixin Zhang, Zhao Chen et al. • Frontiers in Medicine (2024)

BackgroundLow-grade fibromyxoid sarcoma (LGFMS) is a rare type of soft tissue sarcoma that often involves the deep soft tissue of the extremities and trunk in young and middle-aged adults. It is uncommon in the elderly. Here we discuss a ca...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2024.1172746

Dietary Fat Sources Affect Hepatic Health, Performance and Gut Microbiota Composition in Laying Hens as Model

Humera Hamid, Yao Jun Liu, Wen Xiang Li, Shi Meng Huang et al. • Veterinary Medicine and Science (2025)

ABSTRACT Non‐alcoholic fatty liver disease (NAFLD) is a growing concern in both human and animal health, with nutritional strategies playing a key role in its management. This study used a laying hen model to evaluate the effects of two hig...

DOAJ Open Access (DOAJ) DOI: 10.1002/vms3.70665

Nutritional Assessment and Dietary Requirements in Kidney Transplant Patients: A Literature Review as a Clinical Guideline

Sudiyeh Hejri Zarifi, Naseh Pahlavani, Farveh Yahyapoor, Mohsen Nematy et al. • Journal of Fasting and Health (2021)

Kidney transplantation is a preferred treatment and the 'last resort' in chronic kidney disease after end-stage renal disease. Considering the key role of nutrition in post-transplant recovery, the present study aimed to review the nutritio...

DOAJ Open Access (DOAJ) DOI: 10.22038/jnfh.2020.51553.1292

Guidelines for the management of adult penicillin allergy in community and specialist settings in Australia and New Zealand: An AGREE II and Delphi-based approach

Michaela Lucas, MD, FRACP, FRCPA, Jillian Kehoe, MHP BSc (Food Science and Technology), Samantha Stiles, PhD, MPH, MID, BSc, Sandra M. Salter, BPharm, Grad Dip Pharm (Hosp), PhD, FPS et al. • Journal of Allergy and Clinical Immunology: Global (2026)

Background: This guideline was developed in collaboration with the Australasian Society of Clinical Immunology and Allergy (ASCIA), the National Allergy Council and the National Allergy Centre of Excellence (NACE). Despite the abundance of ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jacig.2026.100784