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RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis.

Brianna Dufek, Daniel T Meehan, Duane Delimont, Kevin Wilhelm et al. • PLoS ONE (2020)

Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels o...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0237907

CD56-Negative Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Study in 443 Patients Treated by Chemotherapy With or Without Asparaginase

Jing Yang, Pengfei Li, Pengfei Li, Pengfei Li et al. • Frontiers in Immunology (2022)

ObjectiveExtranodal natural killer/T cell lymphoma (NKTCL) is an aggressive EBV-related lymphoma, originating from NK cells or T cells. Previous study demonstrated that CD56 negative NKTCL should be recognized as a distinct subtype. In this...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2022.829366

Multi-Cohort Transcriptomics Combined with Mendelian Randomization Identifies PPARGC1A, NAAA and GIPC2 as NLRP3 Inflammasome-Related Key Genes in Ulcerative Colitis

Cheng J, Huang Y • Journal of Inflammation Research (2026)

Jian Cheng, Yangfeng Huang Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, School of Medicine,University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of ChinaCorrespond...

DOAJ Open Access (DOAJ)

Atorvastatin suppresses high-risk colorectal adenomas via reprogramming of lipid metabolism and Inhibition of stemness

Wentong Chen, Mengxiao Ge, Shuangyi Sun, Hanxiao Zhang et al. • Scientific Reports (2025)

Abstract As critical precursors to colorectal cancer (CRC), high-risk colorectal adenomas (HR-CRAs) lack effective chemopreventive strategies beyond endoscopic resection. We previously established a standardized protocol for culturing patie...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-32406-y

Constraining PERMANOVA and LDM to within-set comparisons by projection improves the efficiency of analyses of matched sets of microbiome data

Zhengyi Zhu, Glen A. Satten, Caroline Mitchell, Yi-Juan Hu • Microbiome (2021)

Abstract Background Matched-set data arise frequently in microbiome studies. For example, we may collect pre- and post-treatment samples from a set of individuals, or use important confounding variables to match data from case participants ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40168-021-01034-9

CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia

Weiwei Liu, Yan Wang, Zhimei Qiu, Ranzun Zhao et al. • PeerJ (2020)

Background The occurrence of pathological cardiac fibrosis is attributed to tissue hypoxia. Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are involved in the regulation of physiological and pathophy...

DOAJ Open Access (DOAJ) DOI: 10.7717/peerj.9796

Cerebrospinal fluid-stem cell interactions may pave the path for cell-based therapy in neurological diseases

Chao Ren, Peiyuan Yin, Neng Ren, Zhe Wang et al. • Stem Cell Research & Therapy (2018)

Abstract Recent studies have suggested that the regulation of endogenous neural stem cells (NSCs) or transplanting of exogenous nerve cells are the newest and most promising methods for the treatment of dementia and other neurological disea...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13287-018-0807-3

Sex-based estimation of biological variation in plasma-free amino acid concentrations among healthy adults

Müjgan Ercan, Emiş Deniz Akbulut, Ayşen Caniklioğlu, Esra Fırat Oğuz et al. • Journal of Mass Spectrometry and Advances in the Clinical Lab (2025)

Introduction: Free amino acid (FAA) analysis plays a crucial role in diagnosing and monitoring inborn errors of metabolism, assessing nutritional status, and identifying metabolic imbalances associated with various diseases. This study aime...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jmsacl.2025.04.010

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia

Temesgen GB, Menon M, Gizaw ST, Yimenu BW et al. • International Journal of General Medicine (2022)

Gelagey Baye Temesgen,1 Menakath Menon,2 Solomon Tebeje Gizaw,2 Bayu Wondimneh Yimenu,1 Melaku Mekonen Agidew3 1Department of Biomedical Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Medical Biochemistry School o...

DOAJ Open Access (DOAJ)

Impact of Myocardial Ischemia and Revascularization by Percutaneous Coronary Intervention on Circulating Level of Soluble ST2

Alkhateeb A, Mahmoud HEM, AK M, Hassan MH et al. • Vascular Health and Risk Management (2023)

Areej Alkhateeb,1 Hossam Eldin M Mahmoud,1 Mohammed AK,1 Mohammed H Hassan,2 Abdel Rahim Mahmoud Muddathir,3 Ahmed G Bakry1 1Cardiology Division of Internal Medicine Department, South Valley University Hospital, Faculty of Medicine, South V...

DOAJ Open Access (DOAJ)

Functional Assessment of the Quality of Human Hepatocyte Preparations for Cell Transplantation

María Teresa Donato, Agustín Lahoz, Sandra Montero, Ana Bonora et al. • Cell Transplantation (2008)

Hepatocyte transplantation is an alternative therapy to orthotopic liver transplantation for the treatment of liver diseases. Good quality freshly isolated or cryopreserved human hepatocytes are needed for clinical transplantation. However,...

DOAJ Open Access (DOAJ) DOI: 10.3727/096368908787236620

Blood pressure and mortality after percutaneous coronary intervention: a population-based cohort study

Chung-woo Lee, Joo Kyung Lee, Yeon Joo Choi, Hyunjin Kim et al. • Scientific Reports (2022)

Abstract Revascularization procedures, including percutaneous coronary intervention (PCI), for coronary artery disease (CAD) are increasingly performed in Korea. However, studies on blood pressure control targets in these patients remain in...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-022-06627-4

Evaluating key predictors of breast cancer through survival: a comparison of AFT frailty models with LASSO, ridge, and elastic net regularization

Senyefia Bosson-Amedenu, Emmanuel Ayitey, Francis Ayiah-Mensah, Luyton Asare • BMC Cancer (2025)

Abstract Background Frailty models are extensively utilized in survival analysis to address unobserved heterogeneity among individuals. However, selecting the most robust model for survival prediction, especially in the context of high-dime...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12885-025-14040-z

Ethical and social implications of approaching death prediction in humans - when the biology of ageing meets existential issues

Marie Gaille, Marco Araneda, Clément Dubost, Clémence Guillermain et al. • BMC Medical Ethics (2020)

Abstract Background The discovery of biomarkers of ageing has led to the development of predictors of impending natural death and has paved the way for personalised estimation of the risk of death in the general population. This study inten...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12910-020-00502-5

Long-Term Prognosis and Systemic Impact of Acromegaly: Analyses Utilizing Korean National Health Insurance Data

Sangmo Hong, Kyungdo Han, Cheol-Young Park • Endocrinology and Metabolism (2025)

Acromegaly is a rare endocrine disorder caused by excessive growth hormone secretion. Its low prevalence poses challenges in studying its long-term prognosis and systemic effects. To address this research gap, we conducted five studies usin...

DOAJ Open Access (DOAJ) DOI: 10.3803/EnM.2024.2285

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Yan Dora Zhang, Amber N. Hurson, Haoyu Zhang, Parichoy Pal Choudhury et al. • Nature Communications (2020)

In cancer many gene variants may contribute to disease etiology, but the impact of a given gene variant may have varied effect size. Here, the authors analyse summary statistics of genome-wide association studies from fourteen cancers, and ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-020-16483-3

Modeling antiretroviral therapy adherence among people living with HIV: a cross-sectional study at Pantang Hospital, Ghana

Eric Nyarko, Irene A. Kretchy, Grace Lovia Allotey-Babington, Adwoa Oforiwaa Kwakye et al. • BMC Infectious Diseases (2026)

Abstract Background Poor adherence to antiretroviral therapy (ART) continues to undermine HIV treatment outcomes in sub-Saharan Africa, including Ghana. Objective This study aimed to quantify ART treatment adherence among people living with...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12879-026-13836-z

Ranking of treatments in network meta-analysis: incorporating minimally important differences

Tristan Curteis, Augustine Wigle, Christopher J. Michaels, Adriani Nikolakopoulou • BMC Medical Research Methodology (2025)

Abstract Background In network meta-analysis (NMA), the magnitude of difference between treatment effects is typically ignored in the calculation of ranking metrics, such as probability best and surface under the cumulative ranking curve (S...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12874-025-02499-0