Academic Articles & Research Papers

Generation of proximal tubule spheroids for nephrotoxicity assessment

Background To date, nephrotoxicity in new drug development has been evaluated through two-dimensional culture of representative cell lines, such as HK-2 and human proximal tubule epithelial cells (hPTECs). Approximately 20% of new drugs tha...

Preclinical Characterization of Mobocertinib Highlights the Putative Therapeutic Window of This Novel EGFR Inhibitor to EGFR Exon 20 Insertion Mutations

Introduction: EGFR exon 20 insertion mutations account for 10% of all EGFR mutations and are mostly insensitive to approved EGFR tyrosine kinase inhibitors (EGFR TKIs). Novel EGFR TKIs have been developed or repurposed for these mutants. A ...

Tungsten Oxide-contained PEO Coatings on Ti–6Al‑4 V Alloys: Enhanced Surface Characteristics and Bioactivity for Bio-implant

Anticancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) capped silver and zinc oxide nanoparticles and its molecular characterization

Abstract The current investigation reports anti-cancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) and L-Glutaminase capped nanoparticles. The highest L-Glutaminase production of 9.57 U/mL w...

Evaluation of dentinal tubule penetration of a novel nano calcium hydroxide–zinc oxide intracanal medicament: An in vitro pilot study

Background: Residual microorganisms within dentinal tubules remain a key factor in persistent endodontic infections. Therefore, the ability of intracanal medicaments to effectively penetrate these tubules is critical for post-endodontic tre...

Triple-Layered Closure Of An Oroantral Fistula: A Case Report

Introduction: An oroantral fistula (OAF) is an abnormal connection between the oral cavity and the maxillary sinus, usually occurred after the removal of maxillary premolar and molar teeth. Many techniques have been described for closure of...

Evaluating Adenomyosis with Transvaginal Sonography: Diagnostic Precision and Clinical Relevance

Background: Adenomyosis is an important benign gynecological condition among females with variable signs and symptoms. Prompt detection of suspicious cases is important for the effective management of the disease. The objective of the curre...

The Effectiveness of Using Pulpotec® in Treatment of Pulpitis by Pulpotomy of Vital Deciduous Molar and Vital Immature Permanent Molar

Aims: To evaluate the effect of two types of disinfectant solutions(2% alkaline glutaraldehyde, 1% sodium hypochlorite) in wettability of three types of elastomeric impression materials (light body) which are used in crown and bridge restor...

In vitro remineralization of adjacent interproximal enamel carious lesions in primary molars using a bioactive bulk-fill composite

Abstract Background Surface remineralization is recommended for the management of active non-cavitated interproximal carious lesions in primary teeth. According to the American Academy of Pediatric Dentistry, a recently recognized category ...

New dimensions in mechanical plaque control: An overview

Plaque control is the daily removal of dental plaque, oral biofilm and also prevention of their accumulation on the teeth and other parts of oral cavity. Dental plaque is the major etiology of maximum gingival and periodontal diseases. It i...

REVIEW OF MODERN APPROACHES TO DENTAL FLUOROSIS MANAGEMENT

Dental fluorosis is caused by ingesting too much fluoride while the teeth are developing. Poltava region belongs to Buchach fluorine hydrogeological province which ground waters are characterized by a high content of fluorine. Such district...

Efficacy of Propolis-Based Mouthwash on Generalized Chronic Gingivitis: A Randomized Controlled Clinical Trial

Objectives This study aimed to investigate the effect of propolis-based mouthwash on the gingival parameters of generalized chronic gingivitis cases in a randomized controlled clinical trial. Methods A total number of 69 patients with gen...

Artificial Tears: A Systematic Review

David A Semp, Danielle Beeson, Amy L Sheppard, Debarun Dutta, James S Wolffsohn School of Optometry, College of Health and Life Sciences, Aston University, Birmingham, UKCorrespondence: James S Wolffsohn, Tel +44 121 2044140, Email j.s.w.wo...

Peningkatan Aktivitas Pembelajaran Pendidikan Kewarganegaraan Materi Perlindungan dan Penegakan Hukum dengan Metode Kooperatif Tipe STAD Pada Siswa Kelas XII IPS 2 di SMAN 3 Mataram

Abstract: This study aims to improve the learning activities of citizenship education on protection and law enforcement material using STAD of cooperative learning method at the twelvth grade students of Social Science 2 at SMAN 3 Mataram. ...

Multidimensional Fractionation of Particles

The increasing complexity in particle science and technology requires the ability to deal with multidimensional property distributions. We present the theoretical background for multidimensional fractionations by transferring the concepts k...

Transformation Early Childhood Education in Iraq: Challenges, Innovations, and Future Prospects

The article "Transformation Early Childhood Education in Iraq: Challenges, Innovations, and Future Prospects" provides a comprehensive analysis of the current landscape of early childhood education (ECE) in Iraq. Through a systematic litera...

Soviet Empire, Childhood, and Education

Children constituted a key element of the Soviet empire-building project, reconfiguring childhoods and refashioning the colonial space itself.  Children of different ethnicities across the territories of the Soviet republics were to be unit...

How does tax avoidance affect corporate social responsibility and financial ratio in emerging economies?

The purpose of this study is to better understand the relationship between financial ratios and tax avoidance in businesses that practice corporate social responsibility. Using a sample of 30 Tunisian financial institutions listed on the st...

The Belgrade town police in the period of the establishment of the constitutionalists' government

Prince Mihailo Obrenovic took over the administration of the country in the significantly altered the constitutional situation, created by the adoption of the Constitution of 1838 and the departure of Serbian Prince Milos 1839. Constitution...

C no more: a prospective single-arm study to evaluate the effectiveness of a nurse and peer-led mobile model of hepatitis C testing and treatment at community corrections offices

Abstract Background The community corrections population in Australia shares similar risk factors for hepatitis C virus (HCV) infection with people incarcerated in prisons, but without access to prison-based testing and treatment. While hep...