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<i>Carthamus tinctorius</i> Suppresses LPS-Induced Anti-Inflammatory Responses by Inhibiting the MAPKs/NF-κB Signaling Pathway in HaCaT Cells

So-Yeon Kim, Minji Hong, Ponnuvel Deepa, Kandhasamy Sowndhararajan et al. • Scientia Pharmaceutica (2023)

This study aimed to elucidate the anti-inflammatory activity of C. tinctorius leaves by measuring inflammatory parameters such as nitric oxide (NO) production and mRNA expression of iNOS, interleukin-6 (IL-6), and IL-1β in lipopolysaccharid...

DOAJ Open Access (DOAJ) DOI: 10.3390/scipharm91010014

A large deletion conferring pale green leaves of maize

Guoqi Yao, Hua Zhang, Bingying Leng, Bing Cao et al. • BMC Plant Biology (2023)

Abstract Background The structural basis of chloroplast and the regulation of chloroplast biogenesis remain largely unknown in maize. Gene mutations in these pathways have been linked to the abnormal leaf color phenotype observed in some mu...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12870-023-04360-2

Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways

Elliya Park, Lily Yi Li, Chunsheng He, Azhar Z. Abbasi et al. • Advanced Science (2023)

Abstract Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new strategy, using multitargeted bi...

DOAJ Open Access (DOAJ) DOI: 10.1002/advs.202207238

Functional MRI of Handwriting Tasks: A Study of Healthy Young Adults Interacting with a Novel Touch-Sensitive Tablet

Mahta Karimpoor, Nathan W. Churchill, Fred Tam, Corinne E. Fischer et al. • Frontiers in Human Neuroscience (2018)

Handwriting is a complex human activity that engages a blend of cognitive and visual motor skills. Current understanding of the neural correlates of handwriting has largely come from lesion studies of patients with impaired handwriting. Tas...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnhum.2018.00030

Graphene Oxide and Reduced Derivatives, as Powder or Film Scaffolds, Differentially Promote Dopaminergic Neuron Differentiation and Survival

Noela Rodriguez-Losada, Noela Rodriguez-Losada, Rune Wendelbob, M. Carmen Ocaña et al. • Frontiers in Neuroscience (2020)

Emerging scaffold structures made of carbon nanomaterials, such as graphene oxide (GO) have shown efficient bioconjugation with common biomolecules. Previous studies described that GO promotes the differentiation of neural stem cells and ma...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2020.570409

Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts

Camila Fabiani, Camila Fabiani, Silvia S. Antollini, Silvia S. Antollini • Frontiers in Cellular Neuroscience (2019)

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with satu...

DOAJ Open Access (DOAJ) DOI: 10.3389/fncel.2019.00309

Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents

Hoda Zarkoob, Anna Allué-Guardia, Yu-Chi Chen, Andreu Garcia-Vilanova et al. • Communications Biology (2022)

Human alveolar and tracheobronchial epithelial air liquid interface (ALI) tissues are used as models to examine cellular responses to SARS-CoV-2 and influenza A virus infections and as antiviral drug screening assay platforms....

DOAJ Open Access (DOAJ) DOI: 10.1038/s42003-022-03753-7

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson’s Disease: Comparative Analysis of G2019S and I1371V Variants

Khushboo Singh, Roon Banerjee, Chandrakanta Potdar, Anisha Shaw et al. • Cells (2026)

Mutations in leucine-rich repeat kinase 2 (LRRK2) are among the most common genetic causes of Parkinson’s disease (PD), yet substantial heterogeneity exists among pathogenic variants. How mutations in distinct functional domains of LRRK2 di...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells15040342

Dielectric Properties of Phosphatidylcholine Membranes and the Effect of Sugars

Victoria Vitkova, Vesela Yordanova, Galya Staneva, Ognyan Petkov et al. • Membranes (2021)

Simple carbohydrates are associated with the enhanced risk of cardiovascular disease and adverse changes in lipoproteins in the organism. Conversely, sugars are known to exert a stabilizing effect on biological membranes, and this effect is...

DOAJ Open Access (DOAJ) DOI: 10.3390/membranes11110847

<i>Vegfr3</i> and <i>Tbx1</i> Interact in Cardiac Morphogenesis

Stefania Martucciello, Marchesa Bilio, Sara Cioffi, Ilaria Aurigemma et al. • Journal of Cardiovascular Development and Disease (2026)

Gene inactivation in model organisms has identified numerous genes and signaling pathways involved in mammalian cardiac outflow tract (OFT) development. Human genetics data have implicated the VEGFR3 gene in OFT development, but when and wh...

DOAJ Open Access (DOAJ) DOI: 10.3390/jcdd13080399

Effects of the Brazilian Native Fruit Jaboticaba (<i>Plinia cauliflora</i>) Peel on Inflammatory and Oxidative Stress Pathways: Insights from a Pilot Study in Hemodialysis Patients and Renal Cell Models

Ligia Soares Lima, Jessyca Sousa de Brito, Marcelo Ribeiro-Alves, Karen Salve Coutinho-Wolino et al. • Foods (2025)

Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory an...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods14234030

Clinical evaluation of DIAGNOVIR SARS-CoV-2 ultra-rapid antigen test performance compared to PCR-based testing

Ali Aytac Seymen, Ezgi Gulten, Erol Ozgur, Bülend Ortaç et al. • Scientific Reports (2023)

Abstract Coronavirus Disease-19 (COVID-19) is a highly contagious infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The development of rapid antigen tests has contributed to easing the burden on ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-023-31177-8

Nucleotide-binding oligomerization domain protein-1 is expressed and involved in the inflammatory response in human sebocytes

Natsuko Kitajima, Takahisa Nakajo, Takeshi Katayoshi, Kentaro Tsuji-Naito • Biochemistry and Biophysics Reports (2023)

Sebocytes express Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), which participate in the innate immune response of the skin. Although the roles of TLRs and NLR family pyrin domain-cont...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.bbrep.2023.101561

FAM83A as a Potential Biological Marker Is Regulated by miR-206 to Promote Cervical Cancer Progression Through PI3K/AKT/mTOR Pathway

Li Rong, Haiyu Li, Zhaodong Li, Jing Ouyang et al. • Frontiers in Medicine (2020)

Background and Objective: Chemotherapy and radiotherapy are effective treatment options for cervical cancer (CC), but their efficacy is limited by short survival rate of about 5 years particularly for advance stage CC. Bioinformatics analys...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2020.608441

Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19

Irandi Putra Pratomo, Dimas R. Noor, Kusmardi Kusmardi, Andriansjah Rukmana et al. • International Journal of Inflammation (2021)

Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is also expressed in respiratory epithelial cells. Uric acid, which is also considered a ...

DOAJ Open Access (DOAJ) DOI: 10.1155/2021/1653392

Identification of functional pathways for regenerative bioactivity of selected renal cells

Wei Sha, Timothy Bertram, Deepak Jain, Cory Brouwer et al. • Stem Cell Research & Therapy (2022)

Abstract Background Selected renal cells (SRC) are in Phase II clinical trials as a kidney-sourced, autologous, tubular epithelial cell-enriched cell-based therapy for chronic kidney disease (CKD). In preclinical studies with rodent models ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13287-022-02713-6

Can Bacillus paranthracis cause bacteremia in a T-ALL patient? WGS-based diagnosis

Serap Süzük Yıldız, Ayşegül Polat, Süleyman Yalçın, Mert Emre Ölmez et al. • Journal of Infection in Developing Countries (2025)

Introduction: Most of Bacillus spp. generally avirulent species in healthy patients, but if there is a fragile in the patient, especially their immune system, Bacillus spp. can be an agent for infections. Case Report: In this case, we rep...

DOAJ Open Access (DOAJ) DOI: 10.3855/jidc.20080

Proteomic analysis of synergetic neuroprotective effect of adenosine, thiamine, niacin and cyanocobalamin in pathophysiology of diabetic polyneuropathy

O. A. Gromova, I. Yu. Torshin, A. G. Moiseenok • Фармакоэкономика (2025)

Background. Neurotransmitter adenosine and B-group vitamins have neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect ...

DOAJ Open Access (DOAJ) DOI: 10.17749/2070-4909/farmakoekonomika.2024.285

Dysregulation of Angiogenesis and Inflammatory Genes in Endometrial Mesenchymal Stem Cells and Their Contribution to Endometriosis

Shermineh Heydari, Ladan Kashani, Mehrdad Noruzinia • Iranian Journal of Allergy, Asthma and Immunology (2021)

Endometriosis is a common, chronic, inflammatory disorder in women, characterized by the presence of endometrial tissue outside the uterus cavity. The disease affects ~10% of women during their reproductive age. There is some debates on the...

DOAJ Open Access (DOAJ)