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A Benzimidazole-Based N-Heterocyclic Carbene Derivative Exhibits Potent Antiproliferative and Apoptotic Effects against Colorectal Cancer

Sarah Al-Nasser, Maha Hamadien Abdulla, Noura Alhassan, Mansoor-Ali Vaali-Mohammed et al. • Medicina (2024)

Background and Objectives: Colorectal cancer (CRC) remains a major global health issue. Although chemotherapy is the first-line treatment, its effectiveness is limited due to drug resistance developed in CRC. To overcome resistance and impr...

DOAJ Open Access (DOAJ) DOI: 10.3390/medicina60091379

Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Mike B. Barnkob, Yale S. Michaels, Violaine André, Philip S. Macklin et al. • Nature Communications (2024)

Abstract Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton. The exact extent of these effects on tumour-specific T cells are not ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-024-47424-z

Displacement and Emplacement of Health Technology

Pascale Lehoux, Blake D. Poland, Geneviève Daudelin, Dave Holmes et al. • Science Technology & Human Values (2008)

The provision of “closer-to-patient” services has increased in most industrialized countries. However, the migration of services in non-traditional health care settings implies redefining the role of technical and human entities and transfo...

OPENALEX DOI: https://doi.org/10.1177/0162243907306966

Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro

Patthra Pason, Chakrit Tachaapaikoon, Waralee Suyama, Rattiya Waeonukul et al. • Toxicology Reports (2024)

Colorectal carcinoma (CRC) is one of the most common malignancies, though there are no effective therapeutic regimens at present. This study aimed to investigate the inhibitory effects of mannooligosaccharides extracted from coconut meal (C...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.toxrep.2023.12.010

Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt

Lotte B. Romijn, Axel A. Almet, Chin Wee Tan, James M. Osborne • BMC Bioinformatics (2020)

Abstract Background Many cancers arise from mutations in cells within epithelial tissues. Mutations manifesting at the subcellular level influence the structure and function of the tissue resulting in cancer. Previous work has proposed how ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12859-020-3391-3

Data on the cytotoxicity of chlorogenic acid in 3D cultures of HT-29 cells

M. Daniela Vélez, Johanna Pedroza-Díaz, Gloria A. Santa-González • Data in Brief (2023)

Functional foods, beyond basic nutrition, offer health benefits to consumers thanks to the presence of bioactive compounds such as some phytochemicals [1,2]. Today, these foods are of particular interest in biomedical research due to their ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.dib.2023.109527

Visualizing healthcare system variability and resilience: a longitudinal study of patient movements following discharge from a Swedish psychiatric clinic

Jakob Svensson, Johan Bergström • BMC Health Services Research (2020)

Abstract Background As healthcare becomes increasingly complex, new methods are needed to identify weaknesses in the system that could lead to increased risk. Traditionally, the focus for patient safety is to study incident reports and adve...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12913-020-05642-3

Neuroscience in Medicine

P. Michael Conn • Humana Press eBooks (2003)

Cytology and Organization of Cell Types: Light and Electron Microscopy Rochelle S. Cohen and Donald W. Pfaff Anatomy of the Spinal Cord and Brain Bruce E. Maley Ion Channels and Electrical Signaling Stanko S. Stojilkovic A. Clinical Correla...

OPENALEX DOI: https://doi.org/10.1007/978-1-59259-371-2

Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases

Lateef Adegboyega Sulaimon, Lukman Olalekan Afolabi, Rahmat Adetutu Adisa, Akinrinade George Ayankojo et al. • Advances in Redox Research (2022)

The Mitochondria is a critical sub-cellular organelle that plays an integral part in a normal cellular process. Besides ATP production, the mitochondria participate in various key cellular processes such as cell signaling, epigenetic regula...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.arres.2022.100037

Medical biotechnology

Findlay, Joshua • University of Salford Institutional Repository (University of Salford) (2016)

Resistance to entering the UK government's modern slavery victim identification mechanism is widespread and part of normal practices of state evasion that shape the lives of large numbers of insufficiently documented people.This article pro...

OPENALEX cc-by

Green Microfluidic Method for Sustainable and High-Speed Analysis of Basic Amino Acids in Nutritional Supplements

Iva Pukleš, Csilla Páger, Nikola Sakač, Bojan Šarkanj et al. • Molecules (2024)

Amino acids (AAs) have broad nutritional, therapeutic, and medical significance and thus are one of the most common active ingredients of nutritional supplements. Analytical strategies for determining AAs are high-priced and often limited t...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules29235554

Investigating the genetic makeup of the major histocompatibility complex (MHC) in the United Arab Emirates population through next-generation sequencing

Nour al dain Marzouka, Halima Alnaqbi, Amira Al-Aamri, Guan Tay et al. • Scientific Reports (2024)

Abstract The Human leukocyte antigen (HLA) molecules are central to immune response and have associations with the phenotypes of various diseases and induced drug toxicity. Further, the role of HLA molecules in presenting antigens significa...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-024-53986-1

Russia in contemporary Central Asia

Slavomír Horák • Czech Journal of International Relations (2005)

The dissolution of the USSR and creation of the New Independent States (NIS) was accompanied by a rapid deterioration in relationships between the component republics. With the disputable exception of the Baltic States, the close dependence...

DOAJ Open Access (DOAJ)

DOMESTIC VIOLENCE AS MODERN CULTURAL PHENOMENON

O. K. Goncharenko • Концепт: философия, религия, культура (2018)

The Declaration on the elimination of violence against women adopted by the United Nations General Assembly on 20 December, 1993 defines violence against women as “any act of gender-based violence that results in, or islikely to result in, ...

DOAJ Open Access (DOAJ) DOI: 10.24833/2541-8831-2018-3-7-120-132

Transnational ties with the ethnic homeland: the case of Korean women of the CIS in marital migration

Ем Н. • Әл-Фараби Атындағы Қазақ Ұлттық Университеті хабаршы шығыстану сериясы (2020)

Every year, tens of thousands of women from developing countries cross borders to marry men from developed countries. Men in Western Europe and the United States are looking for future partners from Russia and Eastern Europe, while men in E...

DOAJ Open Access (DOAJ)

Symposium on Muslims in Europe

Abdulaziz Sachedina • American Journal of Islam and Society (1992)

The question of a Muslim minority in the Western context has become an important one in view of some h-and-hysteria literatu~th at continues to depict this minority as a threat to Western liberal values and sociopolitical systems. The confe...

DOAJ Open Access (DOAJ) DOI: 10.35632/ajis.v9i2.2564

Water Diplomacy and Non-Traditional Security

Krisman Heriamsal, Rivelda Pricilia Heatubun, Heyna Jekaisa, Andi Ira Tenri Adikusuma • Nation State (2025)

The water scarcity crisis in Iraq has become a non-traditional security issue that threatens the country's social, political and economic stability. According to international data, water scarcity is predicted to worsen by 2030, affecting m...

DOAJ Open Access (DOAJ) DOI: 10.24076/nsjis.v7i2.1387

Refugees in International Relations

Natalia Szablewska • International Journal of Refugee Law (2012)

This volume, as they explain, emerged from the editors’ frustration with the relative marginalisation of the issue of refugees from the dominant scholarship within the discipline of International Relations (IR) (p 4). It is an outcome of a ...

OPENALEX DOI: https://doi.org/10.1093/ijrl/ees005