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Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice

Tara Jois, Weiyi Chen, Victor Howard, Rebecca Harvey et al. • Molecular Metabolism (2017)

Objective: Carbohydrate response element binding protein (ChREBP) is a transcription factor that responds to glucose and activates genes involved in the glycolytic and lipogenic pathways. Recent studies have linked adipose ChREBP to insulin...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.molmet.2017.07.006

Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase

Nicholas J. Tobias, Tilman Ahrendt, Ursula Schell, Melissa Miltenberger et al. • PeerJ (2016)

Several members of the genus Legionella cause Legionnaires’ disease, a potentially debilitating form of pneumonia. Studies frequently focus on the abundant number of virulence factors present in this genus. However, what is often overlooked...

DOAJ Open Access (DOAJ) DOI: 10.7717/peerj.2720

Sex- and age-specific effects of fat distribution on bone mineral density

Xiao Lin, Jun-Jie Yang, Bei Huang, Peng-Xin Wang et al. • Experimental Gerontology (2026)

Background: BMI cannot distinguish fat distribution and may mask the true effects of different fat depots on bone mineral density (BMD). To investigate sex- and age-specific associations between fat distribution and BMD and its mediating ro...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2026.113301

Rare genetic diseases associated with G-quadruplex-induced replication stress

Lauren M. Herr, Swagata Mukhopadhyay, Olivia M. Anderson, Tucker H. Couch et al. • Communications Biology (2026)

Abstract DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary structures that present a substant...

DOAJ Open Access (DOAJ) DOI: 10.1038/s42003-026-09966-4

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

Leon G. Martens, Jiao Luo, Fleur L. Meulmeester, Nadia Ashrafi et al. • Antioxidants (2020)

The antioxidant vitamin E (α-tocopherol, α-TOH) protects lipids from oxidation by reactive oxygen species. We hypothesized that lifestyle factors associate with vitamin E metabolism marked by urinary α-tocopheronolactone hydroquinone (α-TLH...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox9121280

A hybrid nanomodulator enables metabolic microenvironment remodeling for potent immunotherapy against lung adenocarcinoma

Shuping Wang, Pengcheng Chen, Xiaozhen Jing, Jinglin Zou et al. • Materials & Design (2026)

STING agonist-based immunotherapy holds considerable promise for cancer treatment, yet its efficacy against immunologically “cold” tumors such as lung adenocarcinoma (LUAD) remains markedly limited. A major obstacle lies in the highly glyco...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.matdes.2026.117182

Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

Jing Ma, Ruijuan Ma, Xueke Zeng, Liming Zhang et al. • Journal of Experimental & Clinical Cancer Research (2023)

Abstract Background Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13046-023-02768-0

The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State-of-the-Art Review

Seyedeh Alia Moosavian, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar • Bioinorganic Chemistry and Applications (2021)

Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can lead to end-stage liver disease needing a liver transplant. Many pharmacological approaches are used to reduce the disease progression in NAFLD. However, cu...

DOAJ Open Access (DOAJ) DOI: 10.1155/2021/4041415

Silver Nanoparticles Suppress Apple Fire Blight: Antibacterial Activity, Reduced Carbohydrate-Containing EPS Content, and Altered Host Antioxidant Responses

Alexander G. Khina, Maria T. Mukhina, Alexander S. Gordeev, Liliya R. Biktasheva et al. • Plants (2026)

The present study evaluated the phytoprotective activity of silver nanoparticles stabilized with sodium amphopolycarboxyglycinate (AgNPs-APCG) against apple fire blight caused by Erwinia amylovora. A highly colloidally stable AgNPs-APCG dis...

DOAJ Open Access (DOAJ) DOI: 10.3390/plants15203208

Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of diabetic kidney disease (DKD)

Zhi Zheng, Yunkuo Li, Yujie Pan • Cell Death Discovery (2026)

Abstract Diabetic kidney disease (DKD), a prevalent microvascular complication of diabetes, is a leading cause of chronic kidney disease and end-stage renal disease. Moreover, it plays a crucial role in the morbidity and mortality of diabet...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41420-026-03117-8

Morphological features of the Eneolithic — Early Bronze population as a result of adaptation to the geographical and bioclimatic conditions of the Altai highlands

Solodovnikov K.N., Kravchenko G.G., Rykun M.P. • Вестник археологии, антропологии и этнографии (2018)

This paper is aimed at scrutinizing the dependence between the morphological features of the Eneolithic — Early Bronze population and the geographical and bioclimatic conditions in the Altai valleys and intermountain basins. Across the terr...

DOAJ Open Access (DOAJ) DOI: 10.20874/2071-0437-2018-43-4-120-135

Promoting sustainable businesses for strong local communities: Qatar’s wild herbal plants industry

Macro Johann Sebastian Bejarano, Thiago Sabatinelli Rodrigues, Columba Marcelli Sánchez, Kaltham Al-Ghanim et al. • Energy Reports (2020)

Herbal medicine can improve economic diversification and sustainable livelihoods of local communities. In fact, the demand for herbal medicine is increasing globally while policymakers also value non-economic benefits, e.g. preserving tradi...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.egyr.2020.10.058

Elucidating the functions of fabF1 and fabF2 in Pseudomonas aeruginosa: implications for fatty acid metabolism and pathogenicity

Zhe Hu, Junfei Yu, Mengchen Li, Xiangru Liu et al. • BMC Microbiology (2026)

Abstract Background Pseudomonas aeruginosa is an opportunistic pathogen responsible for severe infections in immunocompromised individuals, including burn patients and those with cystic fibrosis. β-Ketoacyl-ACP synthases play essential role...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12866-026-04824-z

The RootChip: An Integrated Microfluidic Chip for Plant Science

Guido Großmann, Woei‐Jiun Guo, David W. Ehrhardt, Wolf Bernd Frommer et al. • The Plant Cell (2011)

Studying development and physiology of growing roots is challenging due to limitations regarding cellular and subcellular analysis under controlled environmental conditions. We describe a microfluidic chip platform, called RootChip, that in...

OPENALEX cc-by DOI: https://doi.org/10.1105/tpc.111.092577 PMC: 3269862

Photosynthetic Research in Plant Science

Ayumi Tanaka, Amane Makino • Plant and Cell Physiology (2009)

Photosynthesis is a highly regulated, multistep process. It encompasses the harvest of solar energy, transfer of excitation energy, energy conversion, electron transfer from water to NADP+, ATP generation and a series of enzymatic reactions...

OPENALEX Open Access DOI: https://doi.org/10.1093/pcp/pcp040 PMC: 2669890

Vitamin Deficiencies in Humans: Can Plant Science Help?

Teresa B. Fitzpatrick, Gilles J. C. Basset, Patrick Borel, Fernando O. Carrari et al. • The Plant Cell (2012)

The term vitamin describes a small group of organic compounds that are absolutely required in the human diet. Although for the most part, dependency criteria are met in developed countries through balanced diets, this is not the case for th...

OPENALEX Open Access DOI: https://doi.org/10.1105/tpc.111.093120 PMC: 3315223

Transcriptomics reveals the mechanism of branching production in response to GR24 in A. gallica 541

Liu Liu, Bing Li, Shoujian Li, Youyan Liu et al. • Scientific Reports (2025)

Abstract Rhizomorphs are specialized structures formed by the intertwining of mycelia in Armillaria and certain other basidiomycete fungi. The growth and branching of rhizomorphs are essential for nutrient acquisition, host colonization, an...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-09015-w

Microbial Electrosynthesis Reshapes Energy Metabolism and Physiology in Clostridium ljungdahlii

Sara Al Sbei, Santiago T. Boto, Thomas Krüger, Kai Papenfort et al. • Microbial Biotechnology (2026)

ABSTRACT Microbial electrosynthesis (MES) enables a variety of microorganisms, particularly acetogens, to utilize electrical energy in the form of electrons to produce valuable compounds from CO2. In the closely related process of gas ferme...

DOAJ Open Access (DOAJ) DOI: 10.1111/1751-7915.70398

Decreased photosynthetic rate under high temperature in wheat is due to lipid desaturation, oxidation, acylation, and damage of organelles

M. Djanaguiraman, D. L. Boyle, R. Welti, S. V. K. Jagadish et al. • BMC Plant Biology (2018)

Abstract Background High temperature is a major abiotic stress that limits wheat (Triticum aestivum L.) productivity. Variation in levels of a wide range of lipids, including stress-related molecular species, oxidative damage, cellular orga...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12870-018-1263-z

Advances in Plant Sciences

Patricia Corral‐Martínez, Lorenzo Ascari, María Flores‐Tornero, Ana Marta Pereira et al. (2020)

Modern botany is a broad, multidisciplinary subject with inputs from most other areas of science and technology. Research topics include the study of plant structure, growth and differentiation, reproduction, biochemistry and primary metabo...

OPENALEX DOI: https://doi.org/10.4236/9781649972740