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Showing 6 of 66 academic articles

Interacting roles of gut microbiota and T cells in the development of autoimmune hepatitis

Qingwei Wu, Zhifa Ge, Chengyu Lv, Qifeng He • Frontiers in Immunology (2025)

Autoimmune hepatitis (AIH) is a progressive liver inflammatory disease mediated by an autoimmune response, with an increasing incidence rate. In severe cases, AIH will rapidly progress to liver cirrhosis and liver failure and even lead to d...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2025.1584001

Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target

Xiaofeng Duan, Stephen Iwanowycz, Soo Ngoi, Megan Hill et al. • Frontiers in Oncology (2021)

During tumor development and progression, intrinsic and extrinsic factors trigger endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the increased expression of molecular chaperones to cope with the stress and...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2021.629846

Immunogenic cell death-related macrophage gene model for prognostic prediction in glioblastoma

Yiming Mao, Ting Li, Wenqiang Lu, Chunhong Li et al. • Discover Oncology (2025)

Abstract Glioblastoma (GBM) is an extremely aggressive and diverse type of brain tumor that is associated with a poor prognosis. Immunogenic cell death (ICD) is a particular form of cellular demise that is closely linked to antineoplastic i...

DOAJ Open Access (DOAJ) DOI: 10.1007/s12672-025-03557-1

A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients

Claire Tardiveau, Claire Tardiveau, Guillaume Monneret, Guillaume Monneret et al. • Frontiers in Immunology (2022)

Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed th...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2022.1022750

Machine Learning in Healthcare

Hafsa Habehh, Suril Gohel • Current Genomics (2021)

Recent advancements in Artificial Intelligence (AI) and Machine Learning (ML) technology have brought on substantial strides in predicting and identifying health emergencies, disease populations, and disease state and immune response, among...

OPENALEX Open Access DOI: https://doi.org/10.2174/1389202922666210705124359 PMC: 8822225

Vital Hepatic Lymphoma Residuum or Excessive Immune Response? Challenging Treatment Decisions in a Patient With Systemic Lupus Erythematosus and Liver-Dominant Diffuse Large B-Cell Lymphoma: Case Report

Lars Kurch, Thomas W. Georgi, Astrid Monecke, Daniel Seehofer et al. • Frontiers in Oncology (2022)

A 28-year-old female patient with active and difficult-to-treat systemic lupus erythematosus (SLE) was diagnosed with liver-dominant diffused large B-cell lymphoma. Repeated response 18F-FDG-PET studies showed persistently high, and, despit...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2021.798757