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Advanced Mathematical Thinking

Tommy Dreyfus • Cambridge University Press eBooks (1990)

This chapter presents the principal currents and results in recent cognitive research on advanced mathematical thinking processes. The ambiguity in the phrase advanced mathematical thinking processes is intentional: The word advanced can an...

OPENALEX DOI: https://doi.org/10.1017/cbo9781139013499.008

Development and validation of a portable, point-of-care canine distemper virus qPCR test.

Ania Tomaszewicz Brown, Denise McAloose, Paul P Calle, Angelika Auer et al. • PLoS ONE (2020)

Canine distemper virus (CDV) is a multi-host pathogen that can cause significant mortality in domestic, wild terrestrial and marine mammals. It is a major conservation threat in some endangered species. Infection can result in severe respir...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0232044

Establishment of two human induced pluripotent stem cell lines from familial long QT syndrome type 1 patients carrying KCNQ1 mutation

Dasom Mun, Gyeongseo Yoo, Malgeum Park, Ji-Young Kang et al. • Stem Cell Research (2024)

Long QT syndrome type 1 (LQT1) is a rare heart disorder caused by a loss-of-function mutation in the KCNQ1 gene that causes loss of Kv7.1 channel function, which can lead to Palpitations, Syncope, and Sudden cardiac arrest. We derived induc...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.scr.2024.103571

Case-based medical informatics

Stefan Valerian Pantazi, José F. Arocha, Jochen R. Moehr • BMC Medical Informatics and Decision Making (2004)

BACKGROUND: The "applied" nature distinguishes applied sciences from theoretical sciences. To emphasize this distinction, we begin with a general, meta-level overview of the scientific endeavor. We introduce the knowledge spectrum and four ...

OPENALEX cc-by DOI: https://doi.org/10.1186/1472-6947-4-19 PMC: 544898

Evaluation of the SH-SY5Y cell line as an in vitro model for potency testing of a neuropeptide-expressing AAV vector

Jeanette Zanker, Daniela Hüser, Adrien Savy, Sara Lázaro-Petri et al. • Frontiers in Molecular Neuroscience (2023)

Viral vectors have become important tools for basic research and clinical gene therapy over the past years. However, in vitro testing of vector-derived transgene function can be challenging when specific post-translational modifications are...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnmol.2023.1280556

Molecular Characterization of Cryptosporidium Species in Children with Diarrhea in North West of Iran

Behroz Mahdavi poor, Mohammad Asgharzadeh, Esmaeel Fallah, Kareem Hatam-Nahavandi et al. • International Journal of Molecular and Cellular Medicine (2015)

Cryptosporidium is one of the most common causes of childhood diarrhea in developing countries. The aim of this randomized pilot study was to detect and characterize infective species and determine the genotypes of Cryptosporidium parasites...

DOAJ Open Access (DOAJ)

Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases

Lateef Adegboyega Sulaimon, Lukman Olalekan Afolabi, Rahmat Adetutu Adisa, Akinrinade George Ayankojo et al. • Advances in Redox Research (2022)

The Mitochondria is a critical sub-cellular organelle that plays an integral part in a normal cellular process. Besides ATP production, the mitochondria participate in various key cellular processes such as cell signaling, epigenetic regula...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.arres.2022.100037

Targeting ferroptosis to rescue osteogenic differentiation in BRONJ-affected jawbone mesenchymal stem cells: the role of miR-145-3p and exosome-mediated therapy

Yi Shuai, Bo Chen, Tao Jiang, Lei Zhu et al. • Journal of Nanobiotechnology (2025)

Abstract Background Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe, therapy-refractory condition driven by ferroptotic disruption of jawbone-derived mesenchymal stem cells (MSCs) biology. We dissect this mechanism to va...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03745-9

Effect of Glycyrrhiza uralensis crude water extract on the expression of Nitric Oxide Synthase 2 gene during myogenesis

Afsha Fatima Qadri, Sibhghatulla Shaikh, Ye Chan Hwang, Khurshid Ahmad et al. • Heliyon (2024)

Glycyrrhiza uralensis is a traditional herbal medicine with significant bioactivity. This study investigated the effect of G. uralensis crude water extract (GU-CWE) on nitric oxide synthase 2 (NOS2) expression during myogenesis. GU-CWE trea...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2024.e34747

Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells

Xinbo Wang, Jiaying Miao, Sizhen Wang, Rongxi Shen et al. • Molecular Cancer (2022)

Abstract Background Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a rare subtype of pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical features. Me...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12943-022-01596-8

Pattern Distribution of Connexins in the Ortho- and Parakeratinized Epithelium of the Lingual Mucosa in Birds

Kinga Skieresz-Szewczyk, Hanna Jackowiak • Cells (2023)

Connexins are important proteins involved in cell-to-cell communication and cytodifferentiation during renewal and cornification of the multilayered epithelia. So far, there is a lack of reports on this subject in birds’ structurally differ...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells12131776

Exogenous gibberellin and spermidine optimize flowering time and ornamental quality by regulating antioxidant capacity, soluble nutrient levels, and endogenous hormone balance of Primula forbesii

Zhuo Lv, Keying Ding, Wenbao Ma, Wenyu Li et al. • Scientia Horticulturae (2026)

Primula forbesii Franch. is a biennial ornamental species increasingly used in flower landscape design, potted displays, and cut flower production. Nevertheless, studies on its flowering regulation remain limited. This study investigated th...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.scienta.2026.114731

Objective Assessment of Maritime VHF Communication Competence Using a Real-Time Simulation Framework

Xuan Long Nguyen, Van Cuong Do, Manh Cuong Nguyen • TransNav (2026)

VHF radiotelephony remains a fundamental component of maritime safety and is mandated by the STCW Convention as an essential operational competency for seaferer. However, existing studies largely focus on basic button-level interaction and ...

DOAJ Open Access (DOAJ) DOI: 10.12716/1001.20.02.22

Allodynia is more frequent in the individuals with more intense attacks of headache and in women

Gêssyca Adryene de Menezes Silva, Simone de Siqueira Bringel, Hugo André de Lima Martins, Rosana Christine Cavalcanti Ximenes et al. • Headache Medicine (2012)

Objective: Identifying the presence of allodynia in students with primary headache in a college. Method: It was evaluated 378 students (273 women) aged between 18 and 45 years (22 ± 5 years). A questionnaire was used on the clinical charact...

DOAJ Open Access (DOAJ) DOI: 10.48208/HeadacheMed.2012.17

Effect of Curcumin on Odontogenic/Osteogenic Differentiation of Dental Pulp Stem Cells

Masoud Seifi, Shirin Farivar, Malihe Sadat Mirhosseini, Atefe Ahmadvand • Regeneration, Reconstruction & Restoration (2020)

Introduction: Stem cells have gained great attention in tissue engineering and curcumin is a natural phenolic product that had showed some positive effects on these cells. The aim of this study was to evaluate the effect of curcumin on the ...

DOAJ Open Access (DOAJ) DOI: 10.22037/rrr.v5i.31127

Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testes

Atsuki Imai, Kazuya Matsuda, Yuki Niimi, Atsushi Suzuki • Scientific Reports (2023)

Abstract Spontaneous testicular teratomas (STTs) are tumours comprising a diverse array of cell and tissue types, which are derived from pluripotent stem-like cells called embryonal carcinoma cells (ECCs). Although mouse ECCs originate from...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-023-33706-x

Fyn Kinase: A Potential Target in Glucolipid Metabolism and Diabetes Mellitus

Ruifeng Xiao, Cong Shen, Wen Shen, Xunan Wu et al. • Current Issues in Molecular Biology (2025)

Fyn is widely involved in diverse cellular physiological processes, including cell growth and survival, and has been implicated in the regulation of energy metabolism and the pathogenesis of diabetes mellitus through multiple pathways. Fyn ...

DOAJ Open Access (DOAJ) DOI: 10.3390/cimb47080623

Molecular Biology of Neuroblastoma

John M. Maris, Katherine K. Matthay • Journal of Clinical Oncology (1999)

UNLABELLED: PURPOSE AND RESULTS: Neuroblastoma, the most common solid extracranial neoplasm in children, is remarkable for its clinical heterogeneity. Complex patterns of genetic abnormalities interact to determine the clinical phenotype. T...

OPENALEX DOI: https://doi.org/10.1200/jco.1999.17.7.2264