Academic Articles & Research Papers

The evolution of digital health technologies in cardiovascular disease research

When implemented in practice, digital technologies have shown improvements in morbidity and mortality outcomes in patients with cardiovascular disease (CVD). For scholars, research into digital technologies in cardiovascular care has been r...

Healthy lifestyle attenuates the clonal hematopoiesis-associated coronary artery disease risk

Lifestyle factors and clonal hematopoiesis of indeterminate potential (CHIP) both contribute to the risk of developing coronary artery disease (CAD), but whether a healthy lifestyle could attenuate CHIP-related CAD risk is unknown. A total ...

A Focus on Simulation in Medical Informatics

This special issue of JAMIA addresses simulation, a methodology that holds great promise for the advancement of information technology in health care. Simulation has been termed a third domain, complementing both natural language and mathem...

Health-related quality of life in Chinese population with non-alcoholic fatty liver disease: a national multicenter survey

Abstract Background Health Related Quality of Life (HRQL) is a multi-dimensional construct that can comprehensively evaluate the patient’s health status, including physical, emotional, mental and social well-being. In this study, we aimed t...

Data on genotypic distribution and linkage disequilibrium of several ANRIL polymorphisms in hemodialysis patients

A long non-coding RNA called ANRIL located on chromosome 9p21.3 has been identified as a novel genetic factor associated with cardiovascular disease. Investigation of several single nucleotide polymorphisms (SNPs) of Noncoding Antisense RNA...

Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes

Preparedness of health facilities in managing hypertension & diabetes mellitus in Kilimanjaro, Tanzania: a cross sectional study

Abstract Background Hypertension and Diabetes mellitus are risk factors for cardiovascular diseases that cause 17 million deaths globally. Many of these deaths could have been prevented if hypertensive and diabetic patients had their blood ...

Cardiovascular risk management system: prerequisites for developing, organization principles, target groups

Cardiovascular morbidity and mortality are associated with high demographic and economic  losses.  Their decrease is one  of the  main lines of development  and improvement of the world health systems. An analysis of the current situation i...

HFA of the ESC Position paper on the management of LVAD supported patients for the non LVAD specialist healthcare provider Part 1: Introduction and at the non‐hospital settings in the community

Abstract The accepted use of left ventricular assist device (LVAD) technology as a good alternative for the treatment of patients with advanced heart failure together with the improved survival of the LVAD‐supported patients on the device a...

Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases

The Mitochondria is a critical sub-cellular organelle that plays an integral part in a normal cellular process. Besides ATP production, the mitochondria participate in various key cellular processes such as cell signaling, epigenetic regula...

Wearable ECG Device and Machine Learning for Heart Monitoring

With cardiovascular diseases (CVD) remaining a leading cause of mortality, wearable devices for monitoring cardiac activity have gained significant, renewed interest among the medical community. This paper introduces an innovative ECG monit...

Use of Stem Cells in the Treatment of Myocardial Infarction

Considerable research has been done in the past few decades to treat ischemic heart disease (stroke). Although drug therapies can improve heart disease and reduce mortality in heart failure, none is able to regenerate damaged heart tissue. ...

A single-cell RNA sequencing dataset of cardiac aging in African Turquoise Killifish

Abstract Aging is a major contributor to functional decline of the heart and various cardiovascular diseases. Alterations across different cardiac cell types must be tightly orchestrated during the normative aging process that has begun to ...

Lifestyle interventions to maternal weight loss after birth: a systematic review

Abstract Background Over the past decades, there has been an increase in overweight and obesity in women of childbearing age, as well as the general population. Overweight and obesity are related to a later, increased risk of type 2 diabete...

Nutritional Epidemiology

Abstract This book is about the complex relationships between diet and risks of important diseases, such as cancer and cardiovascular disease. The book starts with an overview of research strategies in nutritional epidemiology—still a relat...

EFFICACY AND SAFETY OF INCLISIRAN BY BASELINE BODY MASS INDEX: A POST HOC POOLED ANALYSIS OF THE ORION-9, ORION-10 AND ORION-11 PHASE III RANDOMIZED CONTROLLED TRIALS

Therapeutic Area: ASCVD/CVD Risk Factors Background: Excessive bodyweight, often associated with dyslipidemia, may affect the pharmacology of drugs. Inclisiran, a small interfering RNA targeting PCSK9 hepatic mRNA, is an effective LDL-C low...

Gout epidemiology and comorbidities

OBJECTIVE: To review the epidemiology of gout and associated comorbidities. METHODS: We review the key published studies of the epidemiology of gout and associated comorbidities. RESULTS: The prevalence of gout ranged 1-4% worldwide and inc...

Gender Differences in the Association Between Serum Uric Acid and Arteriosclerotic Cardiovascular Risk Among Chinese Type 2 Diabetes Mellitus Patients

Hua Yang,1,* Jian Gao,2,* Shuyu Li,1 Huiling Xia,1 Zhangyan Chen,1 Shanzhu Zhu,1 Zhigang Pan1 1Department of General Practice, Zhongshan Hospital of Fudan University, Shanghai, 200030, People’s Republic of China; 2Department of Nutrit...

Epidemiology of Peripheral Artery Disease

New data on the epidemiology of peripheral artery disease (PAD) are available, and they should be integrated with previous data. We provide an updated, integrated overview of the epidemiology of PAD, a focused literature review was conducte...

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury

Objectives and Aims: Vascular smooth muscle cells (VSMCs) are key constituents of both normal arteries and atherosclerotic plaques. They have an ability to adapt to changes in the local environment by undergoing phenotypic modulation. An im...