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Effect of Overexpression of the Brain-Specific Na+/Ca2+ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells

Yuki Ota, Takuya Kawanai, Ryo Watanabe, Akira Nishimura et al. • Journal of Pharmacological Sciences (2013)

Abstract.: Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicit...

DOAJ Open Access (DOAJ) DOI: 10.1254/jphs.13012SC

Non-invasive large-scale imaging of concurrent neuronal, astrocytic, and hemodynamic activity with hybrid multiplexed fluorescence and magnetic resonance imaging (HyFMRI)

Zhenyue Chen, Yi Chen, Irmak Gezginer, Qingxiang Ding et al. • Light: Science & Applications (2025)

Abstract A critical gap currently exists in systematic understanding and experimental validation of the role of astrocytes in neurovascular coupling and their functional links with other brain cells. Despite a broad selection of functional ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41377-025-02003-9

Sensitivity of aerosol and cloud properties to coupling strength of marine boundary layer clouds over the northwest Atlantic

K. Zeider, K. McCauley, K. McCauley, S. Dmitrovic et al. • Atmospheric Chemistry and Physics (2025)

Quantifying the degree of coupling between marine boundary layer (MBL) clouds and the surface is critical for understanding the evolution of low clouds and explaining the vertical distribution of aerosols and microphysical cloud properties....

DOAJ Open Access (DOAJ) DOI: 10.5194/acp-25-2407-2025

Experimental and Modelling Research on the Effect of Prior Ferrite on Bainitic Transformation in Medium-Carbon Bainitic Steel

Xinpan Yu, Wei Liu, Kang He, Tengfei Wang et al. • Crystals (2024)

In this study, we investigate the impact of prior ferrite on the bainite transformation kinetics and microstructure of medium-carbon steel interrupted by an intercritical annealing (IAA) process. It was found that the incubation time and co...

DOAJ Open Access (DOAJ) DOI: 10.3390/cryst14060487

The Anti-Inflammatory Effect of Low Molecular Weight Fucoidan from <i>Sargassum siliquastrum</i> in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via Inhibiting NF-κB/MAPK Signaling Pathways

Arachchige Maheshika Kumari Jayasinghe, Kirinde Gedara Isuru Sandanuwan Kirindage, Ilekuttige Priyan Shanura Fernando, Kil-Nam Kim et al. • Marine Drugs (2023)

Brown seaweed is a rich source of fucoidan, which exhibits a variety of biological activities. The present study discloses the protective effect of low molecular weight fucoidan (FSSQ) isolated from an edible brown alga, Sargassum siliquast...

DOAJ Open Access (DOAJ) DOI: 10.3390/md21060347

Advances of Single‐Atomic Cobalt Catalysts in Liquid‐Phase Selective Oxidative Reactions

Jiaquan Li, Kai Wang, Yijiao Jiang, Jun Huang et al. • Small Science (2023)

Single‐atom catalysts (SACs) composed of atomically dispersed metal‐active sites embedded in supporting substrates are attracting increasing attention in liquid‐phase selective oxidation reactions with joint merits of both advanced catalyti...

DOAJ Open Access (DOAJ) DOI: 10.1002/smsc.202300079

A new insight on the diffusion growth mechanism of intermetallic compounds in Al-Er system

Zhichao Tang, Jin Cui, Muzhi Yu, Weiqiang Zhu et al. • Materials & Design (2022)

The diffusion growth of intermetallic compounds in Al-Er alloys are closely related to the properties of the alloys. The current work aims at explaining the dominance of Al3Er in the Al-Er alloys precipitation phases and the interface thin ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.matdes.2022.111341

Introduction to Nuclear Engineering

John R. Lamarsh, Edward Melkonian • Physics Today (1977)

(Most chapters end with References and Problems). 1. Nuclear Engineering. 2. Atomic and Nuclear Physics. Fundamental Particles. Atomic and Nuclear Structure. Atomic and Molecular Weight. Atomic and Nuclear Radii. Mass and Energy. Particle W...

OPENALEX DOI: https://doi.org/10.1063/1.3037597

Toxicity and biodistribution comparison of functionalized nanodiamonds, quantum dot nanocarbons and gold nanoparticles

Elena Alexander, Kam W. Leong • Frontiers in Nanotechnology (2025)

IntroductionNanomaterials are extensively utilized in applications ranging from electronics to biomedical therapies; however, their widespread use has prompted concerns about potential toxicity in humans. Understanding the biodistribution a...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnano.2025.1512622

Chitosan nanoparticles as next-generation carriers for veterinary DNA vaccines: Mechanisms, immune responses, and translational prospects

Miguel González-Lozano, José Alberto Cano-Buendía • Veterinary World (2025)

Background and Aim: Chitosan-based DNA nanoparticles have emerged as a promising next-generation platform for veterinary vaccines, addressing several limitations of conventional attenuated, inactivated, and recombinant formulations. Chitosa...

DOAJ Open Access (DOAJ) DOI: 10.14202/vetworld.2025.3826-3838

Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome

Anitha P Govind, Okunola Jeyifous, Theron A Russell, Zola Yi et al. • eLife (2021)

Activity-driven changes in the neuronal surface glycoproteome are known to occur with synapse formation, plasticity, and related diseases, but their mechanistic basis and significance are unclear. Here, we observed that N-glycans on surface...

DOAJ Open Access (DOAJ) DOI: 10.7554/eLife.68910

Identification of DDIT4 as a potential prognostic marker associated with chemotherapeutic and immunotherapeutic response in triple-negative breast cancer

Xuanzhao Chen, Zeyan Li, Meihua Liang, Ziyang Zhang et al. • World Journal of Surgical Oncology (2023)

Abstract Background Triple-negative breast cancer (TNBC) is the most heterogenous and aggressive subtype of breast cancer. Chemotherapy remains the standard treatment option for patients with TNBC owing to the unavailability of acceptable t...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12957-023-03078-7

Exploring Pattaya’s tourism DNA: a mixed-method approach for revisit intention

Chayapoj Lee-Anant, Piyatida Kungwansith, Pimrawee Rocharungsat • Cogent Social Sciences (2025)

This study investigates the structural and symbolic foundations of Pattaya’s tourism identity using a mixed-methods approach that integrates thematic qualitative analysis with Partial Least Squares Structural Equation Modeling (PLS-SEM). It...

DOAJ Open Access (DOAJ) DOI: 10.1080/23311886.2025.2598725

Effective analysis of neurotoxicity and mechanisms of dioctyl terephthalate using network toxicology

Hao Tang, Ting Qin, Zhiwen Yan, Changqing Li et al. • Frontiers in Neuroscience (2026)

ObjectiveDioctyl terephthalate (DOTP), a widely used plasticizer in food packaging and environmental materials, has raised concerns regarding its potential impact on human health. This study aims to investigate the neurotoxicity-related mec...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2026.1783807

Induced Local and Systemic Defense Responses in Tomato Underlying Interactions Between the Root-Knot Nematode Meloidogyne incognita and the Potato Aphid Macrosiphum euphorbiae

Crispus M. Mbaluto, Crispus M. Mbaluto, Esraa M. Ahmad, Anne Mädicke et al. • Frontiers in Plant Science (2021)

Plants mediate interactions between different herbivores that attack simultaneously or sequentially aboveground (AG) and belowground (BG) organs. The local and systemic activation of hormonal signaling pathways and the concomitant accumulat...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpls.2021.632212

Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible <it>IRF1 </it>gene

Auriemma Lauren B, Shah Shaili, Linden Lara M, Henriksen Melissa A • Epigenetics & Chromatin (2012)

Abstract Background The tumor suppressor menin (MEN1) is mutated in the inherited disease multiple endocrine neoplasia type I, and has several documented cellular roles, including the activation and repression of transcription effected by s...

DOAJ Open Access (DOAJ) DOI: 10.1186/1756-8935-5-2

GPR55 activation improves anxiety- and depression-like behaviors of mice during methamphetamine withdrawal

Jinlong Zhang, Jie Yan, Shuyue Li, Qianqian Chen et al. • Heliyon (2024)

Methamphetamine is a potent and highly addictive neurotoxic psychostimulant that triggers a spectrum of adverse emotional responses during withdrawal. G-protein coupled receptor 55 (GPR55), a novel endocannabinoid receptor, is closely assoc...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2024.e30462

Camel Milk Targeting Insulin Receptor—Toward Understanding the Antidiabetic Effects of Camel Milk

Irfa Anwar, Farheen Badrealam Khan, Sajid Maqsood, Mohammed Akli Ayoub et al. • Frontiers in Nutrition (2022)

Camel milk (CM) is known for its beneficial virtues in the human diet and health. This includes its antidiabetic properties demonstrated in many in vitro and in vivo studies. Nevertheless, the scientific rationale behind the molecular and c...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnut.2021.819278

Unraveling the formation mechanism of 3-methylindole from tryptophan in the glucose-mediated Maillard reaction: a combined ReaxFF MD, DFT, and experimental study

Yuan-Yuan Yang, Chao-Kun Wei, Xin Pan, An-Ran Zheng et al. • Food Chemistry: X (2026)

3-Methylindole is a concentration-dependent aroma compound, and its formation mechanism in the tryptophan-glucose Maillard reaction is crucial for flavor regulation but remains incompletely elucidated. Using gas chromatography-olfactometry-...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.fochx.2026.104719