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Academic Articles & Research Papers
Showing 20 of 130 academic articles
Liwei Wu, Qiang Yu, Ping Cheng, Chuanyong Guo • PPAR Research
(2021)
Background. Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damag...
DOAJ
Open Access (DOAJ)
DOI: 10.1155/2021/6626295
Yuta Doshida, Shinichi Hashimoto, Sadahiro Iwabuchi, Yuka Takino et al. • Scientific Reports
(2023)
Abstract Senescent cells are predicted to occur and increase in animal tissues with aging. However, senescent cells in the tissues of aged animals remain to be identified. We refer to the marker genes to identify senescent cells in tissues ...
DOAJ
Open Access (DOAJ)
DOI: 10.1038/s41598-023-41352-6
Hao Tang, Ting Qin, Zhiwen Yan, Changqing Li et al. • Frontiers in Neuroscience
(2026)
ObjectiveDioctyl terephthalate (DOTP), a widely used plasticizer in food packaging and environmental materials, has raised concerns regarding its potential impact on human health. This study aims to investigate the neurotoxicity-related mec...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fnins.2026.1783807
Francesco Valeri, Malena dos Santos Guilherme, Fuqian He, Nicolai M. Stoye et al. • Microorganisms
(2021)
Alzheimer’s disease is a progressive neurodegenerative disorder affecting around 30 million patients worldwide. The predominant sporadic variant remains enigmatic as the underlying cause has still not been identified. Since efficient therap...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/microorganisms9122548
Jinlong Zhang, Jie Yan, Shuyue Li, Qianqian Chen et al. • Heliyon
(2024)
Methamphetamine is a potent and highly addictive neurotoxic psychostimulant that triggers a spectrum of adverse emotional responses during withdrawal. G-protein coupled receptor 55 (GPR55), a novel endocannabinoid receptor, is closely assoc...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.heliyon.2024.e30462
Shiro Okumura, Hironori Koga, Kuniyo Inouye, Eiichi Mizuki • Toxins
(2014)
Parasporin-4 (PS4) is an aerolysin-type β-pore-forming toxin produced by Bacillus thuringiensis strain A1470. It exhibits specific cytotoxicity against human cancer cell lines; therefore, it is expected to be useful for the diagnosis and tr...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/toxins6072115
Thao Nguyen, Toshiaki Yoshikawa, Yusuke Ito, Hitomi Kasuya et al. • STAR Protocols
(2024)
Summary: Chimeric antigen receptor (CAR) T cell therapy often causes serious toxicities, such as cytokine release syndrome (CRS), mainly due to interleukin-6 (IL-6) secreted by monocyte lineage cells. Here, we describe a protocol to generat...
DOAJ
Open Access (DOAJ)
DOI: 10.1016/j.xpro.2024.103423
Gârbo Viorica Irina • Annals of the University of Oradea: Economic Science
(2013)
Malpractice insurance of medical staff is probably the oldest professional liability insurance underwritten in the insurance market in Romania. The aim of our research is to theoretically examine in a qualitative inquiry the usefulness of i...
DOAJ
Open Access (DOAJ)
Huifang Lian, Huifang Lian, Huifang Lian, Huifang Lian et al. • Frontiers in Medicine
(2022)
PurposeFungal keratitis is a sight-threatening corneal infection caused by fungal pathogens, and the pathogenic mechanisms have not been fully elucidated. The aim of this study was to determine whether NOD-like receptor family pyrin domain ...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fmed.2022.845129
Darman Agung Sandakila, Gracetia Devita Hadi, Riska Gultom, Seni Samalele et al. • Aceh Journal of Animal Science
(2024)
The Black Soldier Fly (Hermetia illucens L.) or BSF is one of a group of insects that has a length of 15-20 mm originating from America. The larvae of the BSF has a high protein content (44.26%), which has great potential in treating wound ...
DOAJ
Open Access (DOAJ)
DOI: 10.13170/ajas.9.3.42024
Susana Santos, Tiago Ferreira, José Almeida, Maria J. Pires et al. • Marine Drugs
(2019)
Some diet profiles are associated with the risk of developing cancer; however, some nutrients show protective effects. Porphyra umbilicalis is widely consumed, having a balanced nutritional profile; however, its potential for cancer chemopr...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/md17110615
Guojun Wang, Luiz Gustavo dos Anjos Borges, Daniel Stadlbauer, Irene Ramos et al. • Emerging Microbes and Infections
(2019)
Host switch events of influenza A viruses (IAVs) continuously pose a zoonotic threat to humans. In 2013, swine-origin H1N1 IAVs emerged in dogs soon after they were detected in swine in the Guangxi province of China. This host switch was fo...
DOAJ
Open Access (DOAJ)
DOI: 10.1080/22221751.2019.1637284
Hao Zhang, Hao Zhang, Hao Zhang, Penghui Ye et al. • Frontiers in Immunology
(2026)
BackgroundHigh-altitude hypoxia disrupts intestinal homeostasis by impairing the epithelial barrier, triggering inflammation, and promoting microbial translocation. Berberine (BER), a natural isoquinoline alkaloid with antimicrobial and ant...
DOAJ
Open Access (DOAJ)
DOI: 10.3389/fimmu.2026.1784245
Shaoqi Shi, Xiaoxia Li, Feng Zhang, Zhengqiang Jiang et al. • Foods
(2024)
Oxidative stress is closely linked to aging. Probiotics, whether viable or heat-inactivated, have shown antioxidant properties; however, their effect and mechanism of action in reducing oxidative stress during aging remains underexplored. T...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/foods13223618
Reiko Nakao, Shigeki Shimba, Katsutaka Oishi • Journal of Circadian Rhythms
(2016)
Global deletion of aryl hydrocarbon receptor nuclear translocator-like ('Arntl'; also known as 'Bmal1'), a molecular component of the circadian clock, resulted in an extreme loss of muscle mass. However, the functional role of muscle BMAL1 ...
DOAJ
Open Access (DOAJ)
DOI: 10.5334/jcr.141
Haesoo Jung, Da-Min Jung, Sang-Soo Lee, Eun-Mi Kim et al. • Animal Cells and Systems
(2022)
The crosstalk between androgens and Wnt signaling pathways is critical in the hair growth cycle. Therefore, natural products that target these two pathways for the inhibition of hair loss are sought after. In this study, we investigated the...
DOAJ
Open Access (DOAJ)
DOI: 10.1080/19768354.2022.2085790
Elin M. Weber, Josefina Zidar, Birgit Ewaldsson, Kaisa Askevik et al. • Animals
(2022)
Aggression among group-housed male mice is a major animal welfare concern often observed at animal facilities. Studies designed to understand the causes of male mice aggression have used different methodological approaches and have been het...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/ani13010143
Jui-Fang Kuo, Yin-Hua Cheng, Chun-Wei Tung, Chia-Chi Wang • BMC Veterinary Research
(2024)
Abstract Background Fipronil (FPN) is a broad-spectrum pesticide and commonly known as low toxicity to vertebrates. However, increasing evidence suggests that exposure to FPN might induce unexpected adverse effects in the liver, reproductiv...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s12917-024-03878-3
Kunpeng Liu, Haitao Gong, Binbin Jiao, Zhenshan Ding et al. • Advanced NanoBiomed Research
(2024)
This study aims to evaluate the therapeutic potential of cationic liposomal neostigmine bromide (NB), a novel drug delivery system, for the treatment of detrusor underactivity. By comparing the characteristics of NB‐liposomes (NLP), NB‐β‐cy...
DOAJ
Open Access (DOAJ)
DOI: 10.1002/anbr.202300109
Angelo Corti, Angelina Sacchi, Anna Maria Gasparri, Matteo Monieri et al. • Journal of Nanobiotechnology
(2021)
Abstract Background Gold nanospheres tagged with peptides containing isoDGR (isoAsp-Gly-Arg), an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory cytokines to the tumor vasculature. We prepared bi- o...
DOAJ
Open Access (DOAJ)
DOI: 10.1186/s12951-021-00871-y