Academic Articles & Research Papers

Evaluation of recombinant activated protein C for severe sepsis at a tertiary academic medical center

Kevin E Anger,1 Jeremy R DeGrado,1 Bonnie C Greenwood,1 Steven A Cohen,2 Paul M Szumita1 1Department of Pharmacy, Brigham and Women’s Hospital, Boston, MA, USA; 2Department of Family Medicine and Population Health, Division of Epidemi...

Complete mitochondrial genome sequence of Koelreuteria paniculata (Sapindaceae) and comparative analysis within the family Sapindaceae

Abstract Koelreuteria paniculata (Sapindaceae) is an economically and culturally important species with ornamental traits, durable wood, and medicinal use. Plant mitochondrial (MT) genomes exhibit complex structures and variations in size. ...

Generation Scotland: Linking all the records we can

Objectives We started a family-based genetic epidemiology study in 2006-11 which recruited ~24,000 adult volunteers from ~7000 families across Scotland with consent for follow-up through medical record linkage and re-contact. In 2022-23 we ...

Symptoms of Allergic Rhinitis in Women during Early Pregnancy Are Associated with Higher Prevalence of Allergic Rhinitis in Their Offspring

Background: Epigenetic control of gene expression profiles is a ubiquitous mechanism during cell differentiation, organogenesis and chronic inflammatory reactions. Recent studies have shown that allergen exposure during very early pregnancy...

Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings.

The study of continuously varying, quantitative traits is important in evolutionary biology, agriculture, and medicine. Variation in such traits is attributable to many, possibly interacting, genes whose expression may be sensitive to the e...

Meticulous parade on naringin respecting its pharmacological activities and novel formulations

Objective: Medicinal plants having antioxidant potential possess numerous constituents which are responsible for different beneficial effects and are used as an alternative resource of medicine to lessen diseases linked with oxidative stres...

Clinicopathological features of rare bleeding disorders in high consanguinity population; A retrospective analysis from two tertiary hospitals in Saudi Arabia

BACKGROUND: Rare bleeding disorder (RBDs) encompasses a deficiency of one or more of FXIII, FXI, FX, FVII, FV, FII, and FI clotting factors, leading to bleeding disorders with variable presentations and outcomes ranging from none or minimal...

Multi-dimensional integrated dance therapeutics (MIDT) for fall prevention in community-dwelling older adults.

Early Depression Detection in Social Media: Monitoring of Individual Nighttime Dynamics and Large Language Model Analysis.

ROS-responsive tegafur-pheophorbide a conjugate-loaded microneedles for deep drug delivery and chemo-photodynamic therapy of superficial tumors.

Gelatin macromolecular microspheres constructed by microfluidics regulate the TNF/HIF-1 signaling axis to reshape the bone immune microenvironment and enhance infectious bone defect repair.

Controlled environment agriculture as urban infrastructure: advancing a public agenda for spatial equity.

Integrating metabolomics and transcriptomics to investigate the effects of changes in renal adenosine 5'-monophosphate and arginine metabolism on the mTOR pathway under chronic hypoxia.

Screening of serum biomarkers for coronary artery calcification using DIA quantitative proteomics and construction of a regression model.

Predicting adolescent depression: an interpretable machine learning model.

FMDNet: Spatial-frequency feature routing for low-dose CT denoising.

Early-Stage Co-Creation and Human-Centered Development of Digital Therapeutics for Cognitive Rehabilitation in Early Neurocognitive Disorders: Convergent Mixed Methods Study.

Digital Health: Improve Patient Care while Preserving the Planet, an Ethical Imperative.

Digital Health and Climate Change: Critical Informatics for Change.

Leveraging Digital Health to Heal the Planet.