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Showing 20 of 134 academic articles

MiRNA Profiles in Lymphoblastoid Cell Lines of Finnish Prostate Cancer Families.

Daniel Fischer, Tiina Wahlfors, Henna Mattila, Hannu Oja et al. • PLoS ONE (2015)

BACKGROUND:Heritable factors are evidently involved in prostate cancer (PrCa) carcinogenesis, but currently, genetic markers are not routinely used in screening or diagnostics of the disease. More precise information is needed for making tr...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0127427

ITRI Biofilm Prevented Thoracic Adhesion in Pigs That Received Myocardial Ischemic Induction Treated by Myocardial Implantation of EPCs and ECSW Treatment

Jiunn-Jye Sheu, Jui-Ning Yeh, Pei-Hsun Sung, John Y. Chiang et al. • Cell Transplantation (2024)

This study tested the hypothesis that ITRI Biofilm prevents adhesion of the chest cavity. Combined extracorporeal shock wave (ECSW) + bone marrow-derived autologous endothelial progenitor cell (EPC) therapy was superior to monotherapy for i...

DOAJ Open Access (DOAJ) DOI: 10.1177/09636897241253144

Time-in-range and hypoglycemia in cognitive health of older adults with Type 2 diabetes: An emerging evidence synthesis

Dharmendra Kumar Gupta, Arunima Chaudhuri • Muller Journal of Medical Sciences and Research (2026)

Type 2 diabetes mellitus (T2DM) is a recognized risk factor for cognitive decline and dementia, but the mechanisms linking glycemic dysregulation to brain health remain incompletely understood. Glycated hemoglobin captures long-term average...

DOAJ Open Access (DOAJ) DOI: 10.4103/mjmsr.mjmsr_83_25

Effect of probiotics on cognitive function and cardiovascular risk factors in mild cognitive impairment and Alzheimer’s disease: an umbrella meta-analysis

Bin Xiao, Lina Fu, Zhe Yang, Guran Yu • Journal of Health, Population and Nutrition (2025)

Abstract Background This umbrella meta-analysis evaluates the effects of probiotics on cognitive function and metabolic health in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) by synthesizing findings from meta-analyses of ra...

DOAJ Open Access (DOAJ) DOI: 10.1186/s41043-025-00816-3

Stress Levels Escalate When Repeatedly Performing Tasks Involving Threats

Johan Bertilsson, Johan Bertilsson, Diederick C. Niehorster, Diederick C. Niehorster et al. • Frontiers in Psychology (2019)

Police work may include performing repeated tasks under the influence of psychological stress, which can affect perceptual, cognitive and motor performance. However, it is largely unknown how repeatedly performing stressful tasks physically...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpsyg.2019.01562

Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways

Elliya Park, Lily Yi Li, Chunsheng He, Azhar Z. Abbasi et al. • Advanced Science (2023)

Abstract Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new strategy, using multitargeted bi...

DOAJ Open Access (DOAJ) DOI: 10.1002/advs.202207238

Identification of functional pathways for regenerative bioactivity of selected renal cells

Wei Sha, Timothy Bertram, Deepak Jain, Cory Brouwer et al. • Stem Cell Research & Therapy (2022)

Abstract Background Selected renal cells (SRC) are in Phase II clinical trials as a kidney-sourced, autologous, tubular epithelial cell-enriched cell-based therapy for chronic kidney disease (CKD). In preclinical studies with rodent models ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13287-022-02713-6

Multi-Cohort Transcriptomics Combined with Mendelian Randomization Identifies PPARGC1A, NAAA and GIPC2 as NLRP3 Inflammasome-Related Key Genes in Ulcerative Colitis

Cheng J, Huang Y • Journal of Inflammation Research (2026)

Jian Cheng, Yangfeng Huang Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, School of Medicine,University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of ChinaCorrespond...

DOAJ Open Access (DOAJ)

Ethical and social implications of approaching death prediction in humans - when the biology of ageing meets existential issues

Marie Gaille, Marco Araneda, Clément Dubost, Clémence Guillermain et al. • BMC Medical Ethics (2020)

Abstract Background The discovery of biomarkers of ageing has led to the development of predictors of impending natural death and has paved the way for personalised estimation of the risk of death in the general population. This study inten...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12910-020-00502-5

Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types

Sipeng Shen, Ruyang Zhang, Yue Jiang, Yi Li et al. • Molecular Cancer (2021)

Abstract N6-Methyladenosine (m6A) is an RNA modification that interacts with numerous coding and non-coding RNAs and plays important roles in the development of cancers. Nonetheless, the clinical impacts of m6A interactive genes on these ca...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12943-021-01362-2

Metabolomic sweet spot clock predicts mortality and age-related diseases in the Canadian Longitudinal Study on Aging

Olga Vishnyakova, Joosung Min, Stephen Leach, Xiaowei Song et al. • Communications Medicine (2026)

Abstract Background Chronological age does not capture individual health or resilience. Advances in metabolomics have enabled development of molecular aging biomarkers that capture deviations between biological and chronological age, highli...

DOAJ Open Access (DOAJ) DOI: 10.1038/s43856-026-01375-2

Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures

Dylan G. Chitwood, Qinghua Wang, Kathryn Elliott, Aiyana Bullock et al. • BMC Biotechnology (2021)

Abstract Background As bioprocess intensification has increased over the last 30 years, yields from mammalian cell processes have increased from 10’s of milligrams to over 10’s of grams per liter. Most of these gains in productivity can be ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12896-020-00667-2

Phase 2a/b randomised placebo-controlled dose-escalation trial of triheptanoin for ataxia-telangiectasia: treating mitochondrial dysfunction with anaplerosisResearch in context

Matthew Lynch, Sophie Manoy, Peter D. Sly, Claire E. Wainwright et al. • EBioMedicine (2025)

Summary: Background: Ataxia-telangiectasia (A-T) is a rare multisystem disease characterised by neurodegenerative cerebellar ataxia, lung disease, immune deficiency, high cancer risk, and mitochondrial dysfunction. A-T cells demonstrate de...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ebiom.2025.105840

Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease

Stewart F. Graham, Nolwen L. Rey, Zafer Ugur, Ali Yilmaz et al. • Metabolites (2018)

For people with Parkinson’s disease (PD), considered the most common neurodegenerative disease behind Alzheimer’s disease, accurate diagnosis is dependent on many factors; however, misdiagnosis is extremely common in the prodrom...

DOAJ Open Access (DOAJ) DOI: 10.3390/metabo8040071

Identification of DDIT4 as a potential prognostic marker associated with chemotherapeutic and immunotherapeutic response in triple-negative breast cancer

Xuanzhao Chen, Zeyan Li, Meihua Liang, Ziyang Zhang et al. • World Journal of Surgical Oncology (2023)

Abstract Background Triple-negative breast cancer (TNBC) is the most heterogenous and aggressive subtype of breast cancer. Chemotherapy remains the standard treatment option for patients with TNBC owing to the unavailability of acceptable t...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12957-023-03078-7

Anti-ceramide antibody and sphingosine-1-phosphate as potential biomarkers of unresectable non-small cell lung cancer

Lilla Bűdi, Dániel Hammer, Rita Varga, Veronika Müller et al. • Pathology and Oncology Research (2025)

ObjectivesSpingosine-1-phosphate (S1P) and ceramides are bioactive sphingolipids that influence cancer cell fate. Anti-ceramide antibodies might inhibit the effects of ceramide. The aim of this study was to assess the potential role of circ...

DOAJ Open Access (DOAJ) DOI: 10.3389/pore.2024.1611929

Why do emergency department clinicians miss acute aortic syndrome? A case series and descriptive analysis

Rachel McLatchie, Sarah Wilson, Matthew Reed, Francoise Ticehurst et al. • Emergency Care Journal (2023)

Objectives: To understand why the diagnosis of AAS is missed in the ED, and to characterise the presenting features of cases in which a diagnosis of AAS was missed. Methods: A retrospective case series cohort study was performed, identif...

DOAJ Open Access (DOAJ) DOI: 10.4081/ecj.2023.11153

HEART Camp Connect—Promoting adherence to exercise in adults with heart failure with preserved ejection fraction

Windy W. Alonso, Sara E. Bills, Scott W. Lundgren, Steven J. Keteyian et al. • ESC Heart Failure (2025)

Abstract Aims Most adults with stable heart failure are safe to exercise at a moderate intensity for 150 min/week. Regular participation in exercise may improve outcomes in adults with heart failure with preserved ejection fraction (HFpEF)....

DOAJ Open Access (DOAJ) DOI: 10.1002/ehf2.15341

Red Blood Cells as Potential Repositories of MicroRNAs in the Circulatory System

Liping Sun, Yang Yu, Beifang Niu, Beifang Niu et al. • Frontiers in Genetics (2020)

The amount of erythrocyte-derived microRNAs (miRNAs) represents the majority of miRNAs expressed in whole blood. miR-451, miR-144, and miR-486, which are abundant in red blood cells (RBCs), are involved in the process of erythropoiesis and ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fgene.2020.00442

Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments.

Marina M Watowich, Rachel M Petersen, Layla Brassington, Audrey M Arner et al. • PLoS Genetics (2026)

The apolipoprotein ε4 (APOE ε4) isoform directly alters cholesterol and immune biology and is associated with an increased risk of neurodegenerative and cardiometabolic disease in industrialized settings; nevertheless, APOE ε4-which is ance...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pgen.1012285