Academic Articles & Research Papers

Memantine for Refractory Obsessive-Compulsive Disorder: Protocol for a Pragmatic, Double-blind, Randomized, Parallel-Group, Placebo-Controlled, Monocenter Trial

BackgroundObsessive-compulsive disorder (OCD) is a psychiatric syndrome characterized by unwanted and repetitive thoughts and repeated ritualistic compulsions for decreasing distress. Symptoms can cause severe distress and functional impair...

Effects of environmentally relevant ibuprofen and valproic acid exposure on zebrafish behavior

Active pharmaceutical ingredients (APIs) are increasingly entering aquatic environments due to human and veterinary use, wastewater discharges, and inadequate waste containment, raising significant concerns for both ecosystems and human hea...

Hypertension and medical informatics.

BACKGROUND: Only about 27% of Americans with hypertension have their disease under control. Hypertension in the African-American population has a higher prevalence (32%) and is less likely to be treated or controlled compared with that in t...

An author co-citation analysis of medical informatics.

OBJECTIVE: This study presents the results of an author co-citation analysis of the interdisciplinary field of medical informatics. METHODS: An author co-citation analysis was conducted for the years 1994 to 1998, using the fifty most-cited...

Changes in physical activity and sedentary behavior during the first COVID-19 pandemic- restrictions in Germany: a nationwide survey

Abstract Background The COVID-19 pandemic restrictions posed challenges to maintaining healthy lifestyles and physical well-being. During the first mobility restrictions from March to mid-July 2020, the German population was advised to stay...

Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes

Prenatal to postnatal trajectory of brain growth in complex congenital heart disease

Altered brain development is a common feature of the neurological sequelae of complex congenital heart disease (CHD). These alterations include abnormalities in brain size and growth that begin prenatally and persist postnatally. However, t...

Relating increasing hantavirus incidences to the changing climate: the mast connection

Abstract Background Nephropathia epidemica (NE), an emerging rodent-borne viral disease, has become the most important cause of infectious acute renal failure in Belgium, with sharp increases in incidence occurring for more than a decade. B...

Electronic symptom monitoring of patient-reported outcomes among patients with hepatocellular carcinoma during immunotherapy (PRIME-HCC): protocol for a randomised controlled trial

Introduction Electronic patient-reported outcome (ePROs)-based symptom monitoring benefits health-related quality of life (HRQoL) in various cancers. However, despite the high disease and economic burden of hepatocellular carcinoma (HCC) an...

Smoking and home oxygen therapy: a review and consensus statement from a multidisciplinary Swedish taskforce

Background: Home oxygen therapy (HOT) improves survival in patients with hypoxaemic chronic respiratory disease. Most patients evaluated for HOT are former or active smokers. Oxygen accelerates combustion and smoking may increase the risk o...

Cardiovascular risk management system: prerequisites for developing, organization principles, target groups

Cardiovascular morbidity and mortality are associated with high demographic and economic  losses.  Their decrease is one  of the  main lines of development  and improvement of the world health systems. An analysis of the current situation i...

HFA of the ESC Position paper on the management of LVAD supported patients for the non LVAD specialist healthcare provider Part 1: Introduction and at the non‐hospital settings in the community

Abstract The accepted use of left ventricular assist device (LVAD) technology as a good alternative for the treatment of patients with advanced heart failure together with the improved survival of the LVAD‐supported patients on the device a...

Abnormal cervical cancer screening results among US Veteran and non-Veteran participants in the National Health Interview Survey (NHIS)

Female Veterans report cervical cancer risk factors at higher rates than non-Veterans. Using data from the National Health Interview Survey (NHIS), we tested whether Veterans with a recent cervical cancer screening test were more likely tha...

Is lower back pain a growing issue in Pakistani adult population?

Dear Editor, Low back pain (LBP) is not a disease itself, but it can be a sign of number of a number of conditions, such as pain near the midline, which can occasionally be localized sometimes, and occur between the inferior gluteal folds...

Exploring health literacy pertaining to general wellbeing and chronic disease management among population registered within Primary Healthcare System: A Study protocol.

BackgroundEvidence suggests that high level of health literacy among patients is associated with high levels of accessibility to healthcare, better understanding consent-to-treat forms, increased compliance to treatment (particularly in tak...

A Review of Age-related Macular Degeneration and Current Concepts in Management

Age-related macular degeneration (AMD) is a prevalent and progressive retinal disease that affects a substantial number of elderly individuals worldwide. This manuscript provides a comprehensive overview of the current concepts in the manag...

Multilevel factors associated with self-reported sexually transmitted infections among sexually active women in Africa: a socio-ecological analysis

Abstract Background Sexually transmitted infections (STIs) continue to pose a significant public health challenge globally, negatively impacting reproductive health and increasing the likelihood of infertility, complications during pregnanc...

Healthcare management

People mainly migrate to Delhi for economic opportunities. Being the capital of India, Delhi generates enormous job opportunities for both skilled and unskilled workers. On the flip side, the residents live in unhealthy conditions and treme...

Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study

BackgroundConstipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close...

Early childhood household instability, adolescent structural neural network architecture, and young adulthood depression: A 21-year longitudinal study

Unstable and unpredictable environments are linked to risk for psychopathology, but the underlying neural mechanisms that explain how instability relate to subsequent mental health concerns remain unclear. In particular, few studies have fo...