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Anti-Amnesic Effects of Epigallocatechin Gallate on Scopolamine-Induced Learning and Memory Dysfunction in Sprague-Dawley Rats

Min-Jeong Kim, Eun-Sang Hwang, Kwan Joong Kim, Sungho Maeng et al. • Antioxidants (2021)

Epigallocatechin gallate (EGCG) is a major flavan-3-ol of green tea polyphenols that exhibits various beneficial health effects, including antioxidant, anti-bacterial, and anti-inflammatory properties. This study aimed to evaluate whether E...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox11010001

Correlation between sarcopenia and changes in oligodendrocyte lineage cells in the brains of Alzheimer's disease model mice

Lin-lin Yao, Xiao-ting Ma, Fang-bo Li, Lin-yi Zheng et al. • Experimental Gerontology (2026)

Background: Alzheimer's disease (AD) is a neurodegenerative disorder primarily characterized by cognitive dysfunction. The discovery and identification of non-cognitive symptoms in the preclinical stage hold promise for early diagnosis and ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2026.113057

Equipment in Senior Gyms: Influence on the Behavior of Blood Pressure and Heart Rate of Elderlies

Sillas Oliveira Leonel Júnior, Mateus Dias Antunes, Ramon Gustavo de Moraes Ovando, Ana Paula Serra de Araújo et al. • Geriatrics, Gerontology and Aging (2024)

OBJECTIVE: To analyze the behavior of blood pressure and heart rate in elderly people practicing physical exercises in Maringá, Paraná, Brazil. METHODS: 70 elderly volunteers were evaluated, 41 women and 29 men, with a mean age of 67.2 ± 6....

DOAJ Open Access (DOAJ) DOI: 10.5327/Z2447-211520171700042

Rare genetic diseases associated with G-quadruplex-induced replication stress

Lauren M. Herr, Swagata Mukhopadhyay, Olivia M. Anderson, Tucker H. Couch et al. • Communications Biology (2026)

Abstract DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary structures that present a substant...

DOAJ Open Access (DOAJ) DOI: 10.1038/s42003-026-09966-4

A Familial Case of Multiple Endocrine Neoplasia 2A: From Morphology to Genetic Alterations Penetration in Three Generations of a Family

Lan Chen, Jing-Xin Zhang, Dong-Ge Liu, Hong-Gang Liu • Diagnostics (2023)

This paper illustrates a rare syndrome of multiple endocrine neoplasia type 2A (MEN2A) in a family of three generations. In our case, the father, son and one daughter developed phaeochromocytoma (PHEO) and medullary thyroid carcinoma (MTC) ...

DOAJ Open Access (DOAJ) DOI: 10.3390/diagnostics13050955

Higher calorie intake with adequate exercise is associated with reduced mortality compared with low-calorie diet with equivalent exercise: An observational study from NHANES based on the 2020–2025 Dietary Guidelines for Americans

Hanghang Gan, Yu Yan, Shanshan Jia, Yingqiang Guo et al. • Experimental Gerontology (2025)

Object: To explore the effects of different combinations of calorie intake and exercise on all-cause, cardiovascular and cancer mortality. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Weigh...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2025.112805

Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics

Junqi Yang, Yumin Ma, Jiang Liu, Qingtian Zhu et al. • Experimental Gerontology (2024)

The aging of pancreatic beta cells is closely associated with various diseases, such as impaired glucose tolerance, yet the underlying regulatory mechanisms remain unclear. In this study, we screened young and aged mouse pancreatic beta cel...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2024.112633

Effectiveness of music-based interventions in acute care settings for people living with dementia to reduce anxiety and enhance the care experience: A systematic review.

Victoria McArthur, Susan Everington, Martyn Patel • Archives of Gerontology and Geriatrics Plus (2024)

Introduction: Dementia is a global health priority, with an increasing percentage of overall hospital bed days occupied by people with dementia (PWD). This combined with increased demand and availability of complex scanning means that there...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.aggp.2024.100087

Impact of age-friendly living environment and intrinsic capacity on functional ability in older adults: a cross-sectional study

Yi-Shan Jiang, Hong Shi, Yu-Ting Kang, Ji Shen et al. • BMC Geriatrics (2023)

Abstract Background The World Health Organization (WHO) has proposed healthy aging framework, supposing that intrinsic capacity (IC), environment and their interaction may have influence on functional ability (FA). It was still unclear how ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-023-04089-5

Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults

Yan Zhao, Tingting Chen, Conghua Ji, Yuxin Shang et al. • Experimental Gerontology (2026)

Background: Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2025.113010

Watching Out for Older Drivers

Samuel Durso • MedEdPORTAL (2006)

Abstract Motor vehicle accidents are the leading cause of injury-related deaths among adults age 65 to 74. This risk for traffic fatalities may triple as the numbers of older drivers increases in the coming years. It is the ethical opinion ...

DOAJ Open Access (DOAJ) DOI: 10.15766/mep_2374-8265.194

Neuronal-Derived EV Biomarkers Track Cognitive Decline in Alzheimer’s Disease

Erden Eren, Jeannie-Marie Leoutsakos, Juan Troncoso, Constantine G. Lyketsos et al. • Cells (2022)

The hallmarks of Alzheimer’s disease (AD) pathology are senile plaques containing amyloid-beta (Aβ) and neurofibrillary tangles containing hyperphosphorylated tau. Additional pathologies often co-exist, whereas multiple pathogenic mechanism...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells11030436

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

Leon G. Martens, Jiao Luo, Fleur L. Meulmeester, Nadia Ashrafi et al. • Antioxidants (2020)

The antioxidant vitamin E (α-tocopherol, α-TOH) protects lipids from oxidation by reactive oxygen species. We hypothesized that lifestyle factors associate with vitamin E metabolism marked by urinary α-tocopheronolactone hydroquinone (α-TLH...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox9121280

Measles IgG Antibodies: Is There a Protective Role in COVID 19 Pandemic?‎ ‎

Amira Al Balakosy, Mostafa Alfishawy, Omnia Elnabawy, Azza Hassan et al. • Afro-Egyptian Journal of Infectious and Endemic Diseases (2021)

Background and study aim: Epidemiological   data reported lower death rates of COVID-19 cases   in countries with   higher & ‎recent coverage by measles containing vaccines. In this study we aim to identify measles IgG titer ‎in COVID-1...

DOAJ Open Access (DOAJ) DOI: 10.21608/aeji.2021.72615.1144

Divergent effects of sleep efficiency and sleep medication on episodic memory in mid to late life

Suhani Amin, Dokyung Yoon, Rahul Naveen, Yaseen El-Magharbel et al. • Frontiers in Sleep (2026)

ObjectivesDifferent aspects of sleep quality are known to decline with age, and these changes have been shown to impact performance across multiple cognitive domains. However, despite a growing body of literature, the impact of changes to q...

DOAJ Open Access (DOAJ) DOI: 10.3389/frsle.2025.1691035

Categorias de autocuidado entre pessoas idosas com diabetes: estudo sociopoético [Categories of self-care among older adults with diabetes: a sociopoetic study]

Iraci dos Santos, Renata Gomes Machado Guerra, Leandro Andrade da Silva • Revista Enfermagem UERJ (2015)

Teve-se como objetivo identificar as categorias de autocuidado apresentadas por pessoas idosas com diabetes, considerando suas dimensões física, mental e espiritual. Método sociopoético, aplicando as fases do grupo-pesquisador formado por 1...

DOAJ Open Access (DOAJ) DOI: 10.12957/reuerj.2015.16498

Efeito do Exercício na Funcionalidade, na Depressão e na dor de Idosos Institucionalizados

Alessandra da Silva Oliveira, Claudia Teixeira-Arroyo • Geriatrics, Gerontology and Aging (2024)

Objetivo: Verifi car o efeito de um programa de exercícios físicos funcionais, associados ao componente lúdico, nos sintomas depressivos, na capacidade de realização das atividades da vida diária (AVD) e nos sintomas de dor de idosos instit...

DOAJ Open Access (DOAJ)

The Effect of Ageism and Willingness of Older Adult Care On Caring Behaviors Among New Graduate Nurses: A Descriptive, Correlational Study

Merve Tarhan, Pınar Doğan • Journal of Nursology (2026)

Objective: Despite the increasing ageing population, caring for older adults is not a highly preferred field of nursing in Türkiye and the world; studies examining the attitudes and behaviors of new graduate nurses towards older adult care ...

DOAJ Open Access (DOAJ) DOI: 10.17049/jnursology.1509812

Comparative efficacy of exercise interventions for cognitive health in older adults: A network meta-analysis

Jinhao Zhang, Wei Ye, Wang Li, Fan Zhang et al. • Experimental Gerontology (2025)

Background: Previous studies have consistently demonstrated that exercise mitigates cognitive decline in older adults. However, the most effective types of exercise, along with optimal frequency and duration of interventions, remain inadequ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2025.112768

Advances in the Development of PET Ligands Targeting Histone Deacetylases for the Assessment of Neurodegenerative Diseases

Tetsuro Tago, Jun Toyohara • Molecules (2018)

Epigenetic alterations of gene expression have emerged as a key factor in several neurodegenerative diseases. In particular, inhibitors targeting histone deacetylases (HDACs), which are enzymes responsible for deacetylation of histones and ...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules23020300