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Evidence for the Effectiveness of Remdesivir (GS-5734), a Nucleoside-Analog Antiviral Drug in the Inhibition of IK(M) or IK(DR) and in the Stimulation of IMEP

Wei-Ting Chang, Wei-Ting Chang, Wei-Ting Chang, Ping-Yen Liu et al. • Frontiers in Pharmacology (2020)

Remdesivir (RDV, GS-5734), a broad-spectrum antiviral drug in the class of nucleotide analogs, has been particularly tailored for treatment of coronavirus infections. However, to which extent RDV is able to modify various types of membrane ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2020.01091

Photoluminescent Nanomaterials for Medical Biotechnology

Evgenii L. Guryev, Samah Shanwar, Andrei V. Zvyagin, Sergey Mikhailovich Deyev et al. • Acta Naturae (2021)

Creation of various photoluminescent nanomaterials has significantly expanded the arsenal of approaches used in modern biomedicine. Their unique photophysical properties can significantly improve the sensitivity and specificity of diagnosti...

OPENALEX cc-by DOI: https://doi.org/10.32607/actanaturae.11180 PMC: 8327149

Economic Considerations in Medical Biotechnology

Eugene Mick Kolassa, Tushar B. Padwal • Springer eBooks (2013)

The biotechnology revolution has coincided with another revolution in health care: the emergence of finance and economics as major issues in the use and success of new medical technologies. Health care finance has become a major social issu...

OPENALEX DOI: https://doi.org/10.1007/978-1-4614-6486-0_10

Targeting ferroptosis to rescue osteogenic differentiation in BRONJ-affected jawbone mesenchymal stem cells: the role of miR-145-3p and exosome-mediated therapy

Yi Shuai, Bo Chen, Tao Jiang, Lei Zhu et al. • Journal of Nanobiotechnology (2025)

Abstract Background Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe, therapy-refractory condition driven by ferroptotic disruption of jawbone-derived mesenchymal stem cells (MSCs) biology. We dissect this mechanism to va...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03745-9

Anti-Tick-Borne Encephalitis Virus Activity of Novel Uridine Glycoconjugates Containing Amide or/and 1,2,3-Triazole Moiety in the Linker Structure

Gabriela Brzuska, Gabriela Pastuch-Gawolek, Monika Krawczyk, Boguslaw Szewczyk et al. • Pharmaceuticals (2020)

Tick-borne encephalitis virus (TBEV) transmitted by ticks is a pathogen of great medical importance. As still no effective antiviral treatment is available, in the present study, a series of uridine glycoconjugates containing amide or/and 1...

DOAJ Open Access (DOAJ) DOI: 10.3390/ph13120460

RETRACTED ARTICLE: Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus

Vassilis L. Souliotis, Konstantinos Vougas, Vassilis G. Gorgoulis, Petros P. Sfikakis • Arthritis Research & Therapy (2016)

Abstract Background Excessive autoantibody production characterizing systemic lupus erythematosus (SLE) occurs irrespective of the disease’s clinical status and is linked to increased lymphocyte apoptosis. Herein, we tested the hypothesis t...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13075-016-1081-3

In Vitro Evaluation of Polihexanide, Octenidine and NaClO/HClO-Based Antiseptics against Biofilm Formed by Wound Pathogens

Grzegorz Krasowski, Adam Junka, Justyna Paleczny, Joanna Czajkowska et al. • Membranes (2021)

Chronic wounds complicated with biofilm formed by pathogens remain one of the most significant challenges of contemporary medicine. The application of topical antiseptic solutions against wound biofilm has been gaining increasing interest a...

DOAJ Open Access (DOAJ) DOI: 10.3390/membranes11010062

Chromosomal Instability in Various Generations of Human Mesenchymal Stem Cells Following the Therapeutic Radiation

Majid Sadeghi Moghadam, Hosein Azimian, Jalil Tavakol Afshari, Mohammad Taghi Bahreyni Toossi et al. • Stem Cells International (2023)

Background. Radiotherapy is a crucial treatment for most malignancies. However, it can cause several side effects, including the development of secondary malignancies due to radiation-induced genomic instability (RIGI). The aim of this stud...

DOAJ Open Access (DOAJ) DOI: 10.1155/2023/9991656

Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress

Hwa-Young Lee, Seung-Wook Kim, Geum-Hwa Lee, Min-Kyung Choi et al. • Scientific Reports (2017)

Abstract For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effec...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-017-06872-y

Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy

Wei Liu, Yan Xu, Yi Wang, Lugui Qiu et al. • Journal for ImmunoTherapy of Cancer (2024)

Background Over 50% of patients with relapsed or refractory large B-cell lymphoma (r/r LBCL) receiving CD19-targeted chimeric antigen receptor (CAR19) T-cell therapy fail to achieve durable remission. Early identification of relapse or prog...

DOAJ Open Access (DOAJ) DOI: 10.1136/jitc-2023-008450

Effect of Glycyrrhiza uralensis crude water extract on the expression of Nitric Oxide Synthase 2 gene during myogenesis

Afsha Fatima Qadri, Sibhghatulla Shaikh, Ye Chan Hwang, Khurshid Ahmad et al. • Heliyon (2024)

Glycyrrhiza uralensis is a traditional herbal medicine with significant bioactivity. This study investigated the effect of G. uralensis crude water extract (GU-CWE) on nitric oxide synthase 2 (NOS2) expression during myogenesis. GU-CWE trea...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2024.e34747

Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells

Xinbo Wang, Jiaying Miao, Sizhen Wang, Rongxi Shen et al. • Molecular Cancer (2022)

Abstract Background Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a rare subtype of pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical features. Me...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12943-022-01596-8

Absence of Asymptomatic Malaria Infection in Endemic Area of Bashagard District, Hormozgan Province, Iran

H Turki, S Zoghi, A A Mehrizi, S Zakeri et al. • Iranian Journal of Parasitology (2012)

Background: A successful malaria elimination program calls for enough attention to parasite carri­ers, especially asymptomatic malaria, as well as the diagnosis and treatment of clinical cases. Asymptomatic malaria is an infection that pati...

DOAJ Open Access (DOAJ)

Medical Biotechnology 2020

Magnus Magnusson • Journal of Antimicrobial Agents (2021)

In recent years, the field of medical biotechnology has experienced rapid growth, leading to the development of several innovative techniques for disease prevention, diagnosis and treatment. New methodologies, including polymerase chain rea...

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