Academic Articles & Research Papers

Genetic signatures of exceptional longevity: a comprehensive analysis of coding region single nucleotide polymorphisms (SNPs) in centenarians and supercentenarians

Abstract Aging, a complex biological process, entails sequential changes in organisms that elevate the risk of frailty, disease, and mortality, affecting individuals at the level of cellular, organ, and organism. This process is influenced ...

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

In association with the published article “Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy” (Huang et al., 2017) [1], this data article contains information about deSUMOylat...

The antibiogram of Pus cultures in Federal Tertiary Care Hospital, Islamabad and its utility in antimicrobial stewardshipThe antibiogram of pus cultures in federal tertiary care hospital, Islamabad and its utility in antimicrobial stewardship

Background and Objectives: Antimicrobial resistance has emerged as a significant global health threat. Infections caused by Multi Drug-Resistant (MDR) bacteria pose formidable challenges in terms of treatment options and patient outcomes. P...

SIRT1 and miR-34a as Potential Plasma Biomarkers in the Acute Phase of Ischemic Stroke

Stroke is the major cause of disability and mortality worldwide. Identification of molecular biomarkers in the early hours after stroke is important in terms of both diagnostic and therapeutic applications. miR-34a, a highly expressed miRNA...

Antibody response after pneumococcal vaccination in a large cohort of Italian children and adolescents with Down syndrome

Introduction: Pneumococcal vaccination has significantly decreased the burden of invasive pneumococcal disease in the general population, however studies on effectiveness in Down syndrome (DS) are heterogeneous. In this cross-sectional stud...

Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia

Abstract Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, espec...

RECENT ADVANCES IN MEDICAL BIOTECHNOLOGY AND INNOVATIVE THERAPEUTIC TECHNOLOGIES

Abstract: Medical biotechnology has emerged as a transformative field that integrates molecular biology, genetics, bioinformatics, nanotechnology, and biomedical engineering to improve the prevention, diagnosis, and treatment of human disea...

Prospects of nanoparticle–DNA binding and its implications in medical biotechnology

Oily start towards a medical biotechnology institute.

It is all about bringing scientific discovery in the medical biotechnology field to the bedside of patients \nwho need it, for which an institute is required to transfer the technology from the academic environment \ninto products for the m...

Autistic disorders and medical biotechnology.

chiefly described by three main deficits: 1) deviant communication, 2) impaired reciprocal social interaction, and 3) lim-ited, repetitive and stereotypic patterns of behaviors or interests 1. The world-wide prevalence of ADs is estimated t...

Medical Biotechnology Quick Overview

The Entrez system allows users to search and get information from 37 different databases. The E-utilities serve as the Entrez system's programming interface. Biotechnology is a vast field of biology that involves the development or manufact...

Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms

Abstract The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the ...

Isolation, characterization, and genomic analysis of a novel phage WSPA with lytic activity against Serratia marcescens

ABSTRACT Serratia marcescens is an established pathogen implicated in hospital-acquired infections and is notorious for its propensity to form biofilms on medical devices, leading to persistent environmental contamination and increased infe...

Reimbursement Legislations and Decision Making for Orphan Drugs in Central and Eastern European Countries

BackgroundReimbursement policies influence access of patients to orphan drugs in the European countries.ObjectivesTo provide a comprehensive description of orphan drug reimbursement policies and to assess reimbursement decision-making proce...

Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine

Ovarian cancer (OC) is one of the most common and fatal types of gynecological cancer. OC is usually detected at the advanced stages of the disease, making it highly lethal. miRNAs are single-stranded, small non-coding RNAs with an approxim...

Prevalence of Obesity and Malnutrition among School-Aged Children of the District Peshawar

ABSTRACTMalnutrition and Obesity are worldwide health phenomena so the aims of the study were to assist the prevalence of obesity and malnutrition among school-aged children of the district Peshawar. Institutional based cross-sectional stud...

Current Evidence on Gene-Based and Epigenetic Therapeutic, Diagnostic, and Prognostic Strategies in Epithelial-Derived Carcinomas: A Scoping Review

Background: Epithelial-derived carcinomas exhibit genomic instability due to genetic mutation and epigenetic dysregulation. Mechanisms such as DNA methylation, histone modifications, and noncoding RNA regulation may lead to tumor progressio...

Mitophagy: An Emergence of New Player in Alzheimer’s Disease

Mitochondria provide neurons not only energy as ATP to keep them growing, proliferating and developing, but they also control apoptosis. Due to their high bioenergetic demand, neurons which are highly specific terminally differentiated cell...

Virulence Genes Profile of Multidrug Resistant Pseudomonas aeruginosa Isolated from Iranian Children with UTIs

Virulent and resistant strains Pseudomonas aeruginosa (P. aeruginosa) is one of the most important cause of UTIs in pediatrics. The present study was carried to investigate the frequency of virulence factors in the multi-drug resistant stra...

Lipidomic Analysis of Caenorhabditis elegans Embryos

Metabolomic is an emerging field of system biology. Lipidomic, a branch of metabolomic, aims to characterize lipophilic metabolites in biological systems. Caenorhabditis elegans (C. elegans) is a genetically tractable and versatile animal m...