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Showing 20 of 1,495 academic articles

Comparative assessment of patient education content generated by five large language models on post-stroke complications: A cross-sectional study of safety, accuracy, reliability, readability, and empathy

Long-Xian Liu, Huan-Huan Wang, Shuang Lu, Guo Yu et al. • Digital Health (2026)

Objective To compare the safety, accuracy, reliability, readability, and empathy of patient education content generated by five large language models (LLMs) for post-stroke complications. Methods This CHART-guided cross-sectional comparativ...

DOAJ Open Access (DOAJ) DOI: 10.1177/20552076261493266

Wrist movements induce torque and lever force in the scaphoid: an ex vivo study

Jochen Erhart, Ewald Unger, Philip Schefzig, Peter Varga et al. • Journal of Orthopaedic Surgery and Research (2020)

Abstract Purpose We hypothesised that intercarpal K-wire fixation of adjacent carpal bones would reduce torque and lever force within a fractured scaphoid bone. Methods In eight cadaver wrists, a scaphoid osteotomy was stabilised using a lo...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13018-020-01897-y

Fast Healthcare Interoperability Resources (FHIR) for Interoperability in Health Research: Systematic Review

Carina Nina Vorisek, Moritz Lehne, Sophie Anne Ines Klopfenstein, Paula Josephine Mayer et al. • JMIR Medical Informatics (2022)

BackgroundThe standard Fast Healthcare Interoperability Resources (FHIR) is widely used in health information technology. However, its use as a standard for health research is still less prevalent. To use existing data sources more efficien...

DOAJ Open Access (DOAJ) DOI: 10.2196/35724

Automated measurement of CD8+ T-cell distribution at the tumor epithelial–stromal interface is associated with NSCLC immunotherapy benefit and transcriptomic pathways

Patrick Leo, Hauke Kolster, Hartmut Koeppen, Jennifer Giltnane et al. • Journal of Pathology Informatics (2026)

Whereas anti-PD-(L)1 therapies are widely used in cancer treatment, only a subset of patients achieve long-term survival. Companion diagnostics based on PD-L1 expression have limited predictive power for these therapies, motivating developm...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jpi.2026.100688

Real-World Evaluation of AI-Driven Diabetic Retinopathy Screening in Public Health Settings: Validation and Implementation Study

Mona Duggal, Anshul Chauhan, Vishali Gupta, Ankita Kankaria et al. • JMIR Medical Informatics (2025)

Abstract BackgroundArtificial intelligence (AI) algorithms offer an effective solution to alleviate the burden of diabetic retinopathy (DR) screening in public health settings. However, there are challenges in translating diagno...

DOAJ Open Access (DOAJ) DOI: 10.2196/67529

Digital quality gradient and the burden of elderly depression: A spatial multi kernel SVR analysis of socio economically vulnerable groups in England

Jin Rui, Yijing Li, Hector D. Menendez, Mariana Pinto da Costa • Digital Health (2026)

Digital infrastructure is increasingly understood as part of the contemporary built environment and as a policy-relevant area-level correlate of older adults’ mental health. Existing studies have often relied on linear models and have paid ...

DOAJ Open Access (DOAJ) DOI: 10.1177/20552076261465140

The Reconnecting the Hand and Arm with Brain (ReHAB) Commentary on “An Integrated Brain-Machine Interface Platform With Thousands of Channels”

Kirsch, Robert F, Ajiboye, A Bolu, Miller, Jonathan P • Journal of Medical Internet Research (2019)

Intracortical brain-machine interfaces are a promising technology for allowing people with chronic and severe neurological disorders that resulted in loss of function to potentially regain those functions through neuroprosthetic devices. Th...

DOAJ Open Access (DOAJ) DOI: 10.2196/16339

Metabolic Flexibility to Predict Lifestyle Interventions Outcomes (MEPHISTO): Protocol for Predictive Validation Study and Randomized Controlled Trial

Monika Ludlova, Kateřina Koudelková, Jitka Pallova, Barbora Koudelkova et al. • JMIR Research Protocols (2025)

BackgroundWeight loss is a cornerstone of obesity treatment and diabetes mellitus type 2 (T2D) prevention, but its implementation in clinical practice is limited by its perceived burden and variability in response. Personalizing interventio...

DOAJ Open Access (DOAJ) DOI: 10.2196/67570

A Severe Acute Respiratory Syndrome extranet: supporting local communication and information dissemination

Kealey Cathy M, Akhtar-Danesh Noori, Valaitis Ruta K, Brunetti Glenn M et al. • BMC Medical Informatics and Decision Making (2005)

Abstract Background The objective of this study was to explore the use and perceptions of a local Severe Acute Respiratory Syndrome (SARS) Extranet and its potential to support future information and communication applications. The SARS Ext...

DOAJ Open Access (DOAJ) DOI: 10.1186/1472-6947-5-17

Oxygen nanobubbles of ICG dimers achieve self-cascade photothermal and photodynamic therapy for hypoxia-reversible tumor treatment

Xiang Sun, Zheng Zhang, Moran Wang, Yuqin Chen et al. • Nano Research (2025)

Simultaneous photothermal and photodynamic therapies (PTT and PDT) hold great promise for noninvasive tumor therapy. However, effective regulation of PTT and PDT with optimal synergistic effects remains a challenge. To date, there are only ...

DOAJ Open Access (DOAJ) DOI: 10.26599/NR.2025.94907281

Impact of a Mobile App (LoAD Calc) on the Calculation of Maximum Safe Doses of Local Anesthetics: Protocol for a Randomized Controlled Trial

Pietro Elias Fubini, Georges Louis Savoldelli, Tal Sara Beckmann, Caroline Flora Samer et al. • JMIR Research Protocols (2024)

BackgroundLocal anesthetics (LAs) are regularly used to alleviate pain during medical or surgical procedures. Their use is generally considered safe, but exceeding the maximum recommended doses can lead to LA systemic toxicity, a rare but p...

DOAJ Open Access (DOAJ) DOI: 10.2196/53679

Early Retinal Microvascular Alterations in Young Type 1 Diabetic Patients without Clinical Retinopathy

Alexandra Oltea Dan, Alin Ștefănescu-Dima, Andrei Teodor Bălășoiu, Ileana Puiu et al. • Diagnostics (2023)

The purpose of this study is to identify and quantify preclinical changes with the help of optical coherence tomography angiography (OCTA) within the retinal microcirculation of young type 1 diabetes (T1D) patients without clinical signs of...

DOAJ Open Access (DOAJ) DOI: 10.3390/diagnostics13091648

Brain perfusion imaging in neonates

Jérôme Baranger, Olivier Villemain, Matthias Wagner, Mariella Vargas-Gutierrez et al. • NeuroImage: Clinical (2021)

Abnormal variations of the neonatal brain perfusion can result in long-term neurodevelopmental consequences and cerebral perfusion imaging can play an important role in diagnostic and therapeutic decision-making. To identify at-risk situati...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2021.102756

A novel and accelerated method for integrated alignment and variant calling from short and long reads

Jinnan Hu, Donald Freed, Hanying Feng, Hong Chen et al. • Frontiers in Bioinformatics (2026)

BackgroundIntegrating short- and long-read sequencing technologies has become a promising approach for achieving accurate and comprehensive genomic analysis. Although short-read sequencing (Illumina, etc.) offers high base accuracy and cost...

DOAJ Open Access (DOAJ) DOI: 10.3389/fbinf.2025.1691056

Trends in Proportion of Delirium Among Older Emergency Department Patients in South Korea, 2017–2022

Jeongmin Moon, Seonji Kim, Daesung Lim, Ho Kyung Sung et al. • Western Journal of Emergency Medicine (2025)

Introduction: Delirium is a critical neuropsychiatric condition that surged among older adults during the coronavirus disease 2019 (COVID-19) pandemic, likely due to social isolation resulting from distancing measures. In this study we exam...

DOAJ Open Access (DOAJ) DOI: 10.5811/westjem.41507

Estimation of the probability of daily fluctuations of incidence of COVID-19 according to official data

Andrey Gerasimov, Elena Galkina, Elena Danilova, Irina Ikonnikova et al. • PeerJ (2021)

When studying the dynamics of morbidity and mortality, one should not limit ourselves to analyzing general trends. Interesting information can be obtained from the analysis of deviations in morbidity and mortality from the general dynamics....

DOAJ Open Access (DOAJ) DOI: 10.7717/peerj.11049

A Focus on Simulation in Medical Informatics

James G. Anderson • Journal of the American Medical Informatics Association (2002)

This special issue of JAMIA addresses simulation, a methodology that holds great promise for the advancement of information technology in health care. Simulation has been termed a third domain, complementing both natural language and mathem...

OPENALEX Open Access DOI: https://doi.org/10.1197/jamia.m1167 PMC: 346642

The History and New Trends of Medical Informatics

Izet Mašić • Donald School Journal of Ultrasound in Obstetrics & Gynecology (2013)

ABSTRACT The breakthrough of the computer and information technologies in all the segments of the society, led to the needs for the computer and information technologies. The knowledge of information technology is now part of general litera...

OPENALEX Open Access DOI: https://doi.org/10.5005/jp-journals-10009-1298

Effects of individualized rTMS on functional connectivity related to the default mode network and frontal-parietal network in major depressive disorder: exploratory analysis of a randomized controlled trial

Jing Jin, Yun Wang, Sixiang Liang, Qingchen Fan et al. • NeuroImage: Clinical (2025)

Objective: Repetitive transcranial magnetic stimulation (rTMS) has been shown to alleviate depressive and anxiety symptoms in patients with major depressive disorder (MDD), typically by targeting the dorsolateral (DLPFC) or dorsomedial pref...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2025.103902