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Geriatric Medicine and Gerontology

Edward T. Zawada • IntechOpen eBooks (2019)

This volume is a collection of reports dealing with geriatrics and gerontology. The first section provides an introduction to the common medical and non-medical problems of aging. The second section concentrates on one of the most devastati...

OPENALEX cc-by DOI: https://doi.org/10.5772/intechopen.77654

Recent advances of two-dimensional materials in smart drug delivery nano-systems

Hua Zhang, Taojian Fan, Wen Chen, Yingchun Li et al. • Bioactive Materials (2020)

Smart drug delivery nano-systems show significant changes in their physical or chemical properties in response to slight change in environmental physical and/or chemical signals, and further releasing drugs adjusted to the progression of th...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.bioactmat.2020.06.012

A hybrid nanomodulator enables metabolic microenvironment remodeling for potent immunotherapy against lung adenocarcinoma

Shuping Wang, Pengcheng Chen, Xiaozhen Jing, Jinglin Zou et al. • Materials & Design (2026)

STING agonist-based immunotherapy holds considerable promise for cancer treatment, yet its efficacy against immunologically “cold” tumors such as lung adenocarcinoma (LUAD) remains markedly limited. A major obstacle lies in the highly glyco...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.matdes.2026.117182

Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

Jing Ma, Ruijuan Ma, Xueke Zeng, Liming Zhang et al. • Journal of Experimental & Clinical Cancer Research (2023)

Abstract Background Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13046-023-02768-0

Twins‐like nanodrugs synchronously transport in blood and coalesce inside tumors for sensitive ultrasound imaging and triggerable penetrative drug delivery

Yujun Cai, Gengjia Chen, Minzhao Lin, Bo Li et al. • Aggregate (2024)

Abstract Nanodrugs capable of aggregating in the tumor microenvironment (TME) have demonstrated great efficiency in improving the therapeutic outcome. Among various approaches, the strategy utilizing electrostatic interaction as a driving f...

DOAJ Open Access (DOAJ) DOI: 10.1002/agt2.476

Idiopathic pulmonary fibrosis: Addressing the current and future therapeutic advances along with the role of Sotatercept in the management of pulmonary hypertension

Dalia D. Hadi, Mohammed Dheyaa Marsool Marsool, Ali Dheyaa Marsool Marsool, Neel Vora et al. • Immunity, Inflammation and Disease (2023)

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive and debilitating lung disease characterized by irreversible scarring of the lungs. The cause of IPF is unknown, but it is thought to involve a combination of genetic a...

DOAJ Open Access (DOAJ) DOI: 10.1002/iid3.1079

The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State-of-the-Art Review

Seyedeh Alia Moosavian, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar • Bioinorganic Chemistry and Applications (2021)

Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can lead to end-stage liver disease needing a liver transplant. Many pharmacological approaches are used to reduce the disease progression in NAFLD. However, cu...

DOAJ Open Access (DOAJ) DOI: 10.1155/2021/4041415

In silico design of a triple-negative breast cancer vaccine by targeting cancer testis antigens

Sepideh Parvizpour, Jafar Razmara, Mohammad M. Pourseif, Yadollah Omidi • BioImpacts (2019)

Introduction: Triple-negative breast cancer (TNBC) is an important subtype of breast cancer, which occurs in the absence of estrogen, progesterone and HER-2 receptors. According to the recent studies, TNBC may be a cancer testis antigen (CT...

DOAJ Open Access (DOAJ) DOI: 10.15171/bi.2019.06