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The Downregulation of eIF3a Contributes to Vemurafenib Resistance in Melanoma by Activating ERK via PPP2R1B

Shi-Long Jiang, Shi-Long Jiang, Zhi-Bin Wang, Zhi-Bin Wang et al. • Frontiers in Pharmacology (2021)

Vemurafenib, a BRAF V600E inhibitor, provides therapeutic benefits for patients with melanoma, but the frequent emergence of drug resistance remains a challenge. An understanding of the mechanisms underlying vemurafenib resistance may gener...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2021.720619

Designing mobile health technology for bipolar disorder

Jakob E. Bardram, Mads M. Frost, Károly Szántó, Maria Faurholt‐Jepsen et al. • CHI Conference on Human Factors in Computing Systems (2013)

An increasing number of pervasive healthcare systems are being designed, that allow people to monitor and get feedback on their health and wellness. To address the challenges of self-management of mental illnesses, we have developed the MON...

OPENALEX DOI: https://doi.org/10.1145/2470654.2481364

Effect of Interactive eHealth Interventions on Improving Medication Adherence in Adults With Long-Term Medication: Systematic Review

Pouls, Bart P H, Vriezekolk, Johanna E, Bekker, Charlotte L, Linn, Annemiek J et al. • Journal of Medical Internet Research (2021)

BackgroundMedication nonadherence leads to suboptimal treatment outcomes, making it a major priority in health care. eHealth provides an opportunity to offer medication adherence interventions with minimal effort from health care providers ...

DOAJ Open Access (DOAJ) DOI: 10.2196/18901

Key Variables for Effective eHealth Designs for Individuals With and Without Mental Health Disorders: 2^12-4 Fractional Factorial Experiment

Rotondi, Armando J, Grady, Jonathan, Hanusa, Barbara H, Haas, Gretchen L et al. • Journal of Medical Internet Research (2021)

BackgroundeHealth applications not only offer the potential to increase service convenience and responsiveness but also expand the ability to tailor services to improve relevance, engagement, and use. To achieve these goals, it is critical ...

DOAJ Open Access (DOAJ) DOI: 10.2196/23137

Medical informatics: the professional challenge

Anthony Nowlan • BMJ (1994)

LAN, WAN, PAS, PACS, and DAT—the acronyms trip off the tongue, but still most doctors ask, “What is medical informatics?” It presents an alluring vision. Take the all too familiar nightmare of a doctor in a busy outpatient clinic, reviewing...

OPENALEX Open Access DOI: https://doi.org/10.1136/bmj.309.6966.1385 PMC: 2541331

Demonstration of high value care to improve oral health of a remote Indigenous community in Australia

Sanjeewa Kularatna, Ratilal Lalloo, Jeroen Kroon, Santosh K. K. Tadakamadla et al. • Health and Quality of Life Outcomes (2020)

Abstract Background The oral health of Indigenous children in remote communities is much worse than other population groups in Australia. Providing and maintaining an oral health service is challenging due to the remoteness of communities, ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12955-020-01300-8

Assessing Acceptance and Intention to Use of Home Telemonitoring Among Patients with Liver Cirrhosis: Development and Initial Psychometric Validation of a TAM-Based Questionnaire

Ruxandra-Cristina Marin, Horia Păunescu, Călin Muntean, Daniel Vasile Balaban et al. • Diagnostics (2026)

Background/Objectives: Liver cirrhosis (LC) is a major cause of morbidity and mortality requiring continuous monitoring and early recognition of clinical deterioration. Home telemonitoring is increasingly considered a supportive strategy fo...

DOAJ Open Access (DOAJ) DOI: 10.3390/diagnostics16162635

A Virtual Reading Center Model Using Crowdsourcing to Grade Photographs for Trachoma: Validation Study

Christopher J Brady, R Chase Cockrell, Lindsay R Aldrich, Meraf A Wolle et al. • Journal of Medical Internet Research (2023)

BackgroundAs trachoma is eliminated, skilled field graders become less adept at correctly identifying active disease (trachomatous inflammation—follicular [TF]). Deciding if trachoma has been eliminated from a district or if treatment strat...

DOAJ Open Access (DOAJ) DOI: 10.2196/41233

Deep learning-based multimodal data fusion in bone tumor management: Advances in clinical decision support

Tongtong Huo, Wei Wu, Xiaoliang Chen, Mingdi Xue et al. • Intelligent Oncology (2025)

Bone tumors (BTs)—including osteosarcoma, Ewing sarcoma, and chondrosarcoma—are rare but biologically complex malignancies characterized by pronounced heterogeneity in anatomical location, histological subtype, and molecular alterations. Re...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.intonc.2025.06.005

Isolation, characterisation and antibiotic susceptibility of staphylococcal isolates with special reference to methicillin-resistant Staphylococcus aureus from the anterior nares of healthcare workers in A tertiary healthcare centre

Chaurasia Mukul, Agrawa Neha, Chourasia Ankita, Bhatnagar Monica et al. • Scripta Medica (2021)

Background: Staphylococcus aureus (S. aureus) and its resistant form methicillinresistant S. aureus (MRSA) is one of the most common nosocomial pathogens causing a wide range of infections in humans. The anterior nares are the main ecologic...

DOAJ Open Access (DOAJ) DOI: 10.5937/scriptamed52-31190

Methodology for the Positive Voices 2022 Survey of People With HIV Accessing Care in England, Wales, and Scotland: Cross-Sectional Questionnaire Study

Janey Sewell, Carole Kelly, Adamma Aghaizu, Hannah Kitt et al. • JMIR Research Protocols (2025)

BackgroundDue to advances in treatment, HIV is now a chronic condition with near-normal life expectancy. However, people with HIV continue to have a higher burden of mental and physical health conditions and are impacted by wider socioecono...

DOAJ Open Access (DOAJ) DOI: 10.2196/58531

The thalamus and its subregions – a gateway to obsessive-compulsive disorder

C. Weeland, C. Vriend, Y. Van Der Werf, C. Huyser et al. • European Psychiatry (2022)

Introduction Higher thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population (Boedhoe et al. 2017, Weeland et al. 2021a). Functionally distin...

DOAJ Open Access (DOAJ) DOI: 10.1192/j.eurpsy.2022.239

Data Mining Techniques in Medical Informatics

U. Rajendra Acharya, Wenwei Yu • The Open Medical Informatics Journal (2010)

The advent of high-performance computing has benefited various disciplines in finding practical solutions to their problems, and our health care is no exception to this.Signal processing, image processing, and data mining tools have been de...

OPENALEX cc-by-nc DOI: https://doi.org/10.2174/1874431101004010021 PMC: 2916206

Automated measurement of CD8+ T-cell distribution at the tumor epithelial–stromal interface is associated with NSCLC immunotherapy benefit and transcriptomic pathways

Patrick Leo, Hauke Kolster, Hartmut Koeppen, Jennifer Giltnane et al. • Journal of Pathology Informatics (2026)

Whereas anti-PD-(L)1 therapies are widely used in cancer treatment, only a subset of patients achieve long-term survival. Companion diagnostics based on PD-L1 expression have limited predictive power for these therapies, motivating developm...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jpi.2026.100688

Effects of chronic taurine administration on healthy pregnant rats and the consequences on the offspring: Datasets for motor tests and oxidative stress

Viridiana Vargas-Castro, Ricardo Gomez-Diaz, Victor M. Blanco-Alvarez, Constantino Tomas-Sanchez et al. • Data in Brief (2022)

We present the data for taurine (2-aminoethanesulfonic acid) treatment to healthy pregnant Sprague Dawley rats (SD). At embryonic day 15 (E15), healthy pregnant SD rats were given taurine treatment (50 mg/L drinking water) and then to their...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.dib.2022.108015

Comparison of the effectiveness of an oral combination of thiamine, pyridoxine, and cyanocobalamin with parenteral cyanocobalamin in adolescents with nutritional vitamin B12 deficiency

Ömer Güneş, Mehmet Ağıllı, Fatih Üçkardeş, Yüksel Hakan Aydoğmuş et al. • Gülhane Tıp Dergisi (2024)

Aims: Nutritional vitamin B12 deficiency remains a significant public health issue. This study aimed to compare the efficacy of an oral combination of thiamine, pyridoxine, cyanocobalamin, and parenteral cyanocobalamin treatment among adole...

DOAJ Open Access (DOAJ) DOI: 10.4274/gulhane.galenos.2024.47135

Optimal@NRW: optimized acute care of nursing home residents using an intersectoral telemedical cooperation network — study protocol for a stepped-wedge trial

David Brücken, Jenny Unterkofler, Sophie Pauge, Jonas Bienzeisler et al. • Trials (2022)

Abstract Background Increasing life expectancy is associated with a growing number of people living in nursing homes, while the availability of outpatient medical care, especially from family doctors, is stagnating in this sector. Consequen...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13063-022-06613-1

Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data

Milena Engelke, Jorge Piano Simões, Laura Basso, Nina Wunder et al. • npj Digital Medicine (2025)

Abstract Intensive longitudinal sampling enhances subjective data collection by capturing real-time, dynamic inputs in natural settings, complementing traditional methods. This study evaluates the feasibility of using daily self-reported ap...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41746-024-01425-w